Changes in Coagulation and Fibrinolytic Indices in Women with Polycystic Ovarian Syndrome Undergoing Controlled Ovarian Hyperstimulation
Background. Polycystic ovarian syndrome (PCOS) women undergoing in vitro fertilization and embryo transfer (IVF-ET) treatment always attain a low cumulative pregnancy rate disaccording with the satisfactory number of oocytes. Objective. We aim to evaluate the status of coagulation and fibrinolytic s...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/731498 |
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| author | Ying Huang Yong Zhao Ling Yan Yun-Hai Chuai Ling-Ling Liu Yi Chen Min Li Ai-Ming Wang |
| author_facet | Ying Huang Yong Zhao Ling Yan Yun-Hai Chuai Ling-Ling Liu Yi Chen Min Li Ai-Ming Wang |
| author_sort | Ying Huang |
| collection | DOAJ |
| description | Background. Polycystic ovarian syndrome (PCOS) women undergoing in vitro fertilization and embryo transfer (IVF-ET) treatment always attain a low cumulative pregnancy rate disaccording with the satisfactory number of oocytes. Objective. We aim to evaluate the status of coagulation and fibrinolytic system in PCOS patients undergoing controlled ovarian hyperstimulation (COH) process. Method. Of the 97 women, 30 patients with PCOS composed the study group; 67 women of child-bearing age with normal endocrine function composed the control group. All participants underwent GnRH agonist standard long protocol, and plasma HCY, FVIII, FX, and D-dimer levels as well as hormone parameters were measured at day of full downregulation, hCG priming, and embryos transfer. Results. On day of full downregulation, FX levels were significantly higher in PCOS group (P<0.01). On hCG priming day, FX and estrogen levels in PCOS group were higher than in the control group and FVIII levels were significantly lower on day of embryos transfer whereas FX and E2 levels were significantly higher in PCOS group. Conclusion. Hypercoagulable state during peri-implantation phase would probably lead to poor microcirculation of endometrium and be one of the most important disadvantages of successful implantation and subsequent clinical pregnancy. |
| format | Article |
| id | doaj-art-2464efda432e4439b82cf5b20f9d0b38 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-2464efda432e4439b82cf5b20f9d0b382025-08-20T02:04:41ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/731498731498Changes in Coagulation and Fibrinolytic Indices in Women with Polycystic Ovarian Syndrome Undergoing Controlled Ovarian HyperstimulationYing Huang0Yong Zhao1Ling Yan2Yun-Hai Chuai3Ling-Ling Liu4Yi Chen5Min Li6Ai-Ming Wang7Department of Reproductive Center, Navy General Hospital, Fucheng Road, Beijing 100048, ChinaDepartment of Reproductive Center, Navy General Hospital, Fucheng Road, Beijing 100048, ChinaDepartment of Reproductive Center, Navy General Hospital, Fucheng Road, Beijing 100048, ChinaDepartment of Reproductive Center, Navy General Hospital, Fucheng Road, Beijing 100048, ChinaDepartment of Reproductive Center, Navy General Hospital, Fucheng Road, Beijing 100048, ChinaDepartment of Reproductive Center, Navy General Hospital, Fucheng Road, Beijing 100048, ChinaDepartment of Reproductive Center, Navy General Hospital, Fucheng Road, Beijing 100048, ChinaDepartment of Reproductive Center, Navy General Hospital, Fucheng Road, Beijing 100048, ChinaBackground. Polycystic ovarian syndrome (PCOS) women undergoing in vitro fertilization and embryo transfer (IVF-ET) treatment always attain a low cumulative pregnancy rate disaccording with the satisfactory number of oocytes. Objective. We aim to evaluate the status of coagulation and fibrinolytic system in PCOS patients undergoing controlled ovarian hyperstimulation (COH) process. Method. Of the 97 women, 30 patients with PCOS composed the study group; 67 women of child-bearing age with normal endocrine function composed the control group. All participants underwent GnRH agonist standard long protocol, and plasma HCY, FVIII, FX, and D-dimer levels as well as hormone parameters were measured at day of full downregulation, hCG priming, and embryos transfer. Results. On day of full downregulation, FX levels were significantly higher in PCOS group (P<0.01). On hCG priming day, FX and estrogen levels in PCOS group were higher than in the control group and FVIII levels were significantly lower on day of embryos transfer whereas FX and E2 levels were significantly higher in PCOS group. Conclusion. Hypercoagulable state during peri-implantation phase would probably lead to poor microcirculation of endometrium and be one of the most important disadvantages of successful implantation and subsequent clinical pregnancy.http://dx.doi.org/10.1155/2014/731498 |
| spellingShingle | Ying Huang Yong Zhao Ling Yan Yun-Hai Chuai Ling-Ling Liu Yi Chen Min Li Ai-Ming Wang Changes in Coagulation and Fibrinolytic Indices in Women with Polycystic Ovarian Syndrome Undergoing Controlled Ovarian Hyperstimulation International Journal of Endocrinology |
| title | Changes in Coagulation and Fibrinolytic Indices in Women with Polycystic Ovarian Syndrome Undergoing Controlled Ovarian Hyperstimulation |
| title_full | Changes in Coagulation and Fibrinolytic Indices in Women with Polycystic Ovarian Syndrome Undergoing Controlled Ovarian Hyperstimulation |
| title_fullStr | Changes in Coagulation and Fibrinolytic Indices in Women with Polycystic Ovarian Syndrome Undergoing Controlled Ovarian Hyperstimulation |
| title_full_unstemmed | Changes in Coagulation and Fibrinolytic Indices in Women with Polycystic Ovarian Syndrome Undergoing Controlled Ovarian Hyperstimulation |
| title_short | Changes in Coagulation and Fibrinolytic Indices in Women with Polycystic Ovarian Syndrome Undergoing Controlled Ovarian Hyperstimulation |
| title_sort | changes in coagulation and fibrinolytic indices in women with polycystic ovarian syndrome undergoing controlled ovarian hyperstimulation |
| url | http://dx.doi.org/10.1155/2014/731498 |
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