Changes in expression of inflammatory cytokines and ocular indicators in pre-diabetic patients with cataract
Abstract Pre-diabetes is the preceding condition of diabetes, and in some cases, fundus changes have been seen in pre-diabetes. The inflammatory response is widely recognized as being involved in the pathophysiologic process of diabetic eye disease. Therefore, we aimed to acquire understanding of th...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-025-03892-5 |
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| author | Yixun Chen Yan meng Mengjia Tan Jun Ma Jian Zhu Min Ji Huaijin Guan |
| author_facet | Yixun Chen Yan meng Mengjia Tan Jun Ma Jian Zhu Min Ji Huaijin Guan |
| author_sort | Yixun Chen |
| collection | DOAJ |
| description | Abstract Pre-diabetes is the preceding condition of diabetes, and in some cases, fundus changes have been seen in pre-diabetes. The inflammatory response is widely recognized as being involved in the pathophysiologic process of diabetic eye disease. Therefore, we aimed to acquire understanding of the role of early altered blood glucose levels in the development and etiology of diabetic ocular disorders from the perspective of inflammation. In this study, serum, tear, aqueous humor and vitreous fluid samples were collected from patients undergoing cataract surgery. VEGF, IL-6, TNF-a, MCP-1, APOA-1, ICAM-1, VCAM-1, PEDF, TSP-1 were measured by ELISA. The quantity of hyperreflective retinal spots (HRS) was counted by optical coherence tomography OCT images. We found that the levels of inflammatory cytokines are already altered in pre-diabetes. Levels of pro-inflammatory cytokine expression and quantity of HRS can reflect the disease process to some extent. |
| format | Article |
| id | doaj-art-2461a07fe7fd48e9835d7920203cc91f |
| institution | DOAJ |
| issn | 1471-2415 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj-art-2461a07fe7fd48e9835d7920203cc91f2025-08-20T02:56:15ZengBMCBMC Ophthalmology1471-24152025-03-0125111410.1186/s12886-025-03892-5Changes in expression of inflammatory cytokines and ocular indicators in pre-diabetic patients with cataractYixun Chen0Yan meng1Mengjia Tan2Jun Ma3Jian Zhu4Min Ji5Huaijin Guan6Eye Institute, Affiliated Hospital of Nantong University, Medical School of Nantong UniversityEye Institute, Affiliated Hospital of Nantong University, Medical School of Nantong UniversityEye Institute, Affiliated Hospital of Nantong University, Medical School of Nantong UniversityEye Institute, Affiliated Hospital of Nantong University, Medical School of Nantong UniversityEye Institute, Affiliated Hospital of Nantong University, Medical School of Nantong UniversityEye Institute, Affiliated Hospital of Nantong University, Medical School of Nantong UniversityEye Institute, Affiliated Hospital of Nantong University, Medical School of Nantong UniversityAbstract Pre-diabetes is the preceding condition of diabetes, and in some cases, fundus changes have been seen in pre-diabetes. The inflammatory response is widely recognized as being involved in the pathophysiologic process of diabetic eye disease. Therefore, we aimed to acquire understanding of the role of early altered blood glucose levels in the development and etiology of diabetic ocular disorders from the perspective of inflammation. In this study, serum, tear, aqueous humor and vitreous fluid samples were collected from patients undergoing cataract surgery. VEGF, IL-6, TNF-a, MCP-1, APOA-1, ICAM-1, VCAM-1, PEDF, TSP-1 were measured by ELISA. The quantity of hyperreflective retinal spots (HRS) was counted by optical coherence tomography OCT images. We found that the levels of inflammatory cytokines are already altered in pre-diabetes. Levels of pro-inflammatory cytokine expression and quantity of HRS can reflect the disease process to some extent.https://doi.org/10.1186/s12886-025-03892-5Pre-diabetesDiabetic retinopathyInflammatory cytokinesHyperreflective foci |
| spellingShingle | Yixun Chen Yan meng Mengjia Tan Jun Ma Jian Zhu Min Ji Huaijin Guan Changes in expression of inflammatory cytokines and ocular indicators in pre-diabetic patients with cataract BMC Ophthalmology Pre-diabetes Diabetic retinopathy Inflammatory cytokines Hyperreflective foci |
| title | Changes in expression of inflammatory cytokines and ocular indicators in pre-diabetic patients with cataract |
| title_full | Changes in expression of inflammatory cytokines and ocular indicators in pre-diabetic patients with cataract |
| title_fullStr | Changes in expression of inflammatory cytokines and ocular indicators in pre-diabetic patients with cataract |
| title_full_unstemmed | Changes in expression of inflammatory cytokines and ocular indicators in pre-diabetic patients with cataract |
| title_short | Changes in expression of inflammatory cytokines and ocular indicators in pre-diabetic patients with cataract |
| title_sort | changes in expression of inflammatory cytokines and ocular indicators in pre diabetic patients with cataract |
| topic | Pre-diabetes Diabetic retinopathy Inflammatory cytokines Hyperreflective foci |
| url | https://doi.org/10.1186/s12886-025-03892-5 |
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