Parry–Romberg Syndrome with Uhthoff’s Phenomena: A Spectrum of Autoimmune Disease?
Parry–Romberg syndrome (PRS) is a rare disorder characterized by unilateral facial atrophy. Currently, the pathogenesis of PRS is poorly understood and no definitive treatment is available. This article reports the case of a 51-year-old woman with progressive hemifacial atrophy following herpes zost...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Immunology |
| Online Access: | http://dx.doi.org/10.1155/2019/1752456 |
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| author | Samuel Asanad |
| author_facet | Samuel Asanad |
| author_sort | Samuel Asanad |
| collection | DOAJ |
| description | Parry–Romberg syndrome (PRS) is a rare disorder characterized by unilateral facial atrophy. Currently, the pathogenesis of PRS is poorly understood and no definitive treatment is available. This article reports the case of a 51-year-old woman with progressive hemifacial atrophy following herpes zoster infection, who presented with a concomitant chronic history of heat-induced diplopia. Magnetic resonance imaging showed unilateral cerebral white matter, periventricular, and medial longitudinal fasciculus lesions. The patient’s diplopia resolved following treatment with valacyclovir. Infection has been previously considered as potential cause of PRS. However, herpes-induced PRS with ophthalmologic manifestations of Uhthoff’s phenomena has not previously been reported. The present case suggests that PRS may possibly have an autoimmune etiology resembling that of multiple sclerosis. |
| format | Article |
| id | doaj-art-245f327b7b3a461fbb600706eb1012ea |
| institution | Kabale University |
| issn | 2090-6609 2090-6617 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Immunology |
| spelling | doaj-art-245f327b7b3a461fbb600706eb1012ea2025-02-03T01:26:21ZengWileyCase Reports in Immunology2090-66092090-66172019-01-01201910.1155/2019/17524561752456Parry–Romberg Syndrome with Uhthoff’s Phenomena: A Spectrum of Autoimmune Disease?Samuel Asanad0David Geffen School of Medicine, University of California, Los Angeles, USAParry–Romberg syndrome (PRS) is a rare disorder characterized by unilateral facial atrophy. Currently, the pathogenesis of PRS is poorly understood and no definitive treatment is available. This article reports the case of a 51-year-old woman with progressive hemifacial atrophy following herpes zoster infection, who presented with a concomitant chronic history of heat-induced diplopia. Magnetic resonance imaging showed unilateral cerebral white matter, periventricular, and medial longitudinal fasciculus lesions. The patient’s diplopia resolved following treatment with valacyclovir. Infection has been previously considered as potential cause of PRS. However, herpes-induced PRS with ophthalmologic manifestations of Uhthoff’s phenomena has not previously been reported. The present case suggests that PRS may possibly have an autoimmune etiology resembling that of multiple sclerosis.http://dx.doi.org/10.1155/2019/1752456 |
| spellingShingle | Samuel Asanad Parry–Romberg Syndrome with Uhthoff’s Phenomena: A Spectrum of Autoimmune Disease? Case Reports in Immunology |
| title | Parry–Romberg Syndrome with Uhthoff’s Phenomena: A Spectrum of Autoimmune Disease? |
| title_full | Parry–Romberg Syndrome with Uhthoff’s Phenomena: A Spectrum of Autoimmune Disease? |
| title_fullStr | Parry–Romberg Syndrome with Uhthoff’s Phenomena: A Spectrum of Autoimmune Disease? |
| title_full_unstemmed | Parry–Romberg Syndrome with Uhthoff’s Phenomena: A Spectrum of Autoimmune Disease? |
| title_short | Parry–Romberg Syndrome with Uhthoff’s Phenomena: A Spectrum of Autoimmune Disease? |
| title_sort | parry romberg syndrome with uhthoff s phenomena a spectrum of autoimmune disease |
| url | http://dx.doi.org/10.1155/2019/1752456 |
| work_keys_str_mv | AT samuelasanad parryrombergsyndromewithuhthoffsphenomenaaspectrumofautoimmunedisease |