Negative Pressure Smart Patch to Sense and Heal the Wound
Abstract Negative pressure wound therapy (NPWT) offers significant advantages in terms of rate and time for healing through generating sub‐vacuum to draw out inflammatory exudate and promote wound closure. However, continuous drainage probably leads to healing delay due to the lack of information ab...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202408077 |
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| author | Xing Liu Peng Zhao Xiaozhuo Wu Yawei Zhao Feifan Zhou Ying Luo Xiaoli Jia Wen Zhong Malcolm Xing Guozhong Lyu |
| author_facet | Xing Liu Peng Zhao Xiaozhuo Wu Yawei Zhao Feifan Zhou Ying Luo Xiaoli Jia Wen Zhong Malcolm Xing Guozhong Lyu |
| author_sort | Xing Liu |
| collection | DOAJ |
| description | Abstract Negative pressure wound therapy (NPWT) offers significant advantages in terms of rate and time for healing through generating sub‐vacuum to draw out inflammatory exudate and promote wound closure. However, continuous drainage probably leads to healing delay due to the lack of information about the real status of the wound bed and the potential risk of infection. To address this concern, printed Negative Pressure Smart Patch (NPSP) is reported by integrating smart real‐time sensing acidity (infection) and glucose, and anti‐infection into NPWT systems. In addition, NPSP delivers vancomycin through chitosan porous microspheres under negative pressure to modulate wound healing. Compared with NPWT, NPSP projects a promising approach to removing bacteria, reducing local inflammation, and accelerating healing in a short period of time. |
| format | Article |
| id | doaj-art-245d847873c54a8da26865cb11c0c272 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-245d847873c54a8da26865cb11c0c2722025-01-20T13:04:18ZengWileyAdvanced Science2198-38442025-01-01123n/an/a10.1002/advs.202408077Negative Pressure Smart Patch to Sense and Heal the WoundXing Liu0Peng Zhao1Xiaozhuo Wu2Yawei Zhao3Feifan Zhou4Ying Luo5Xiaoli Jia6Wen Zhong7Malcolm Xing8Guozhong Lyu9Engineering Research Center of the Ministry of Education for Wound Repair Technology Jiangnan University Affiliated Hospital of Jiangnan University Wuxi 214000 ChinaEngineering Research Center of the Ministry of Education for Wound Repair Technology Jiangnan University Affiliated Hospital of Jiangnan University Wuxi 214000 ChinaDepartment of Mechanical Engineering University of Manitoba Winnipeg R3T 2N2 CanadaDepartment of Biosystems Engineering University of Manitoba Winnipeg R3T 2N2 CanadaEngineering Research Center of the Ministry of Education for Wound Repair Technology Jiangnan University Affiliated Hospital of Jiangnan University Wuxi 214000 ChinaEngineering Research Center of the Ministry of Education for Wound Repair Technology Jiangnan University Affiliated Hospital of Jiangnan University Wuxi 214000 ChinaEngineering Research Center of the Ministry of Education for Wound Repair Technology Jiangnan University Affiliated Hospital of Jiangnan University Wuxi 214000 ChinaDepartment of Biosystems Engineering University of Manitoba Winnipeg R3T 2N2 CanadaDepartment of Mechanical Engineering University of Manitoba Winnipeg R3T 2N2 CanadaEngineering Research Center of the Ministry of Education for Wound Repair Technology Jiangnan University Affiliated Hospital of Jiangnan University Wuxi 214000 ChinaAbstract Negative pressure wound therapy (NPWT) offers significant advantages in terms of rate and time for healing through generating sub‐vacuum to draw out inflammatory exudate and promote wound closure. However, continuous drainage probably leads to healing delay due to the lack of information about the real status of the wound bed and the potential risk of infection. To address this concern, printed Negative Pressure Smart Patch (NPSP) is reported by integrating smart real‐time sensing acidity (infection) and glucose, and anti‐infection into NPWT systems. In addition, NPSP delivers vancomycin through chitosan porous microspheres under negative pressure to modulate wound healing. Compared with NPWT, NPSP projects a promising approach to removing bacteria, reducing local inflammation, and accelerating healing in a short period of time.https://doi.org/10.1002/advs.202408077drug deliveryglucose‐sensingmicrospherespH‐sensingwound monitoring |
| spellingShingle | Xing Liu Peng Zhao Xiaozhuo Wu Yawei Zhao Feifan Zhou Ying Luo Xiaoli Jia Wen Zhong Malcolm Xing Guozhong Lyu Negative Pressure Smart Patch to Sense and Heal the Wound Advanced Science drug delivery glucose‐sensing microspheres pH‐sensing wound monitoring |
| title | Negative Pressure Smart Patch to Sense and Heal the Wound |
| title_full | Negative Pressure Smart Patch to Sense and Heal the Wound |
| title_fullStr | Negative Pressure Smart Patch to Sense and Heal the Wound |
| title_full_unstemmed | Negative Pressure Smart Patch to Sense and Heal the Wound |
| title_short | Negative Pressure Smart Patch to Sense and Heal the Wound |
| title_sort | negative pressure smart patch to sense and heal the wound |
| topic | drug delivery glucose‐sensing microspheres pH‐sensing wound monitoring |
| url | https://doi.org/10.1002/advs.202408077 |
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