KMT2C/D deficiency promotes breast cancer metastasis by regulating KDM6A‐mediated epigenetic remodeling

KMT2C/D deficiency promotes breast cancer metastasis by regulating KDM6A‐mediated epigenetic remodeling

Saved in:

Bibliographic Details
Main Authors:	Zhao Huang, Wei Zhao
Format:	Article
Language:	English
Published:	Wiley 2024-12-01
Series:	MedComm – Oncology
Online Access:	https://doi.org/10.1002/mog2.95
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration
by: Shu‐Guang Yang, et al.
Published: (2025-04-01)

Role of KDM2B epigenetic factor in regulating calcium signaling in prostate cancer cells
by: Evangelia Pantazaka, et al.
Published: (2024-07-01)

Epigenetic remodeling under oxidative stress: Mechanisms driving tumor metastasis
by: Peilan Peng, et al.
Published: (2024-12-01)

Acetylated KIAA1429 by TIP60 facilitates metastasis and immune evasion of hepatocellular carcinoma via N6-methyladenosine-KDM5B-mediated regulation of FoxO1
by: Hu Quan, et al.
Published: (2025-04-01)

KDM3A and KDM3B regulate alternative splicing in mouse pluripotent stem cells
by: Caleb M. Dillingham, et al.
Published: (2025-06-01)

KDM6A Deficiency Induces Myeloid Bias and Promotes CMML‐Like Disease Through JAK/STAT3 Activation by Repressing SOCS3
by: Huiqiao Chen, et al.
Published: (2025-06-01)

KDM6A downregulation promotes tumor-prone cytokines expression in cancer-associated fibroblasts by activating enhancers
by: Jieying Zhang, et al.
Published: (2025-07-01)

Novel cancer stem cell-targeted retinoid ZSH-512 impedes colorectal cancer progress via KDM3A-mediated epigenetic reprogramming
by: Suyao Li, et al.
Published: (2025-04-01)

Virus-human chromatin interactions reorganise 3D genome and hijack KDM5B for promoting metastasis in nasopharyngeal carcinoma
by: Dittman Lai-Shun Chung, et al.
Published: (2025-08-01)

Kdm6a deficiency restricted to mouse hematopoietic cells causes an age- and sex-dependent myelodysplastic syndrome-like phenotype.
by: Ling Tian, et al.
Published: (2021-01-01)

KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression
by: Ouqiang Wu, et al.
Published: (2024-11-01)

Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12
by: Selina Troester, et al.
Published: (2025-05-01)

KDM6A facilitates Xist upregulation at the onset of X inactivation
by: Josephine Lin, et al.
Published: (2025-01-01)

Epigenetic editing and epi-drugs: a combination strategy to simultaneously target KDM4 as a novel anticancer approach
by: Federica Sarno, et al.
Published: (2025-06-01)

Epigenetic Remodeling in Male Germline Development
by: Na Li, et al.
Published: (2016-01-01)

KDM4B enhances immune surveillance via demethylating cGAS
by: Qiao Peng, et al.
Published: (2025-07-01)

The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis
by: Marie Balslev Backe, et al.
Published: (2019-01-01)

KDM1A Promotes Immunosuppression in Hepatocellular Carcinoma by Regulating PD-L1 through Demethylating MEF2D
by: Yonglan Wang, et al.
Published: (2021-01-01)

N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis
by: Haisheng Zhang, et al.
Published: (2025-01-01)

Long non-coding RNA CAR10 promotes angiogenesis of lung adenocarcinoma by mediating nuclear LDHA to epigenetically regulate VEGFA/C
by: Xiaolu Ge, et al.
Published: (2025-01-01)

HMGA2 interacts with KAT6A to regulate MMPs chromatin architecture and promote triple-negative breast cancer metastasis
by: Lu Qiao, et al.
Published: (2025-05-01)

Secernin‐2 Stabilizes Histone Methyltransferase KMT2C to Suppress Progression and Confer Therapeutic Sensitivity to PARP Inhibition in Triple‐Negative Breast Cancer
by: Min‐Ying Huang, et al.
Published: (2025-03-01)

KDM2B regulates stroke injury by modulating OGT-mediated 0-GlcNAcylation of SLC7A11
by: Yi Li, et al.
Published: (2024-11-01)

UHRF1-mediated epigenetic reprogramming regulates glycolysis to promote progression of B-cell acute lymphoblastic leukemia
by: Yan Huang, et al.
Published: (2025-04-01)

Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance
by: Guo-Qing Chen, et al.
Published: (2020-01-01)

Preliminary investigation of the epigenetic regulation of KMT2D via H3K4me1/H3K27ac in oral squamous cell carcinoma
by: Mujie Yuan, et al.
Published: (2025-06-01)

Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy
by: Yunfeng Yuan, et al.
Published: (2025-05-01)

Genetic and epigenetic regulation of Treg cell fitness by autism-related chromatin remodeler CHD8
by: Jun-Qi Yang, et al.
Published: (2025-03-01)

Correction: Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy
by: Tong Shen, et al.
Published: (2025-06-01)

Novel KDM2B/SAV1 Signaling Pathway Promotes the Progression of Gastric Cancer
by: Ning Li, et al.
Published: (2023-01-01)

KDM1A epigenetically enhances RAD51 expression to suppress the STING-associated anti-tumor immunity in esophageal squamous cell carcinoma
by: Qingyuan Yang, et al.
Published: (2024-12-01)

The LncRNA STEAP3-AS1 promotes liver metastasis in colorectal cancer by regulating histone lactylation through chromatin remodelling
by: Jinjuan Lv, et al.
Published: (2025-07-01)

Cytokine and epigenetic regulation of CEACAM6 mediates EGFR-driven signaling and drug response in lung adenocarcinoma
by: Ming-Yi Zheng, et al.
Published: (2025-04-01)

Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets
by: Claire Vinel, et al.
Published: (2025-02-01)

RETRACTED: Hsa_circ_002178 Promotes the Growth and Migration of Breast Cancer Cells and Maintains Cancer Stem-like Cell Properties Through Regulating miR-1258/KDM7A Axis
by: Wangyong Li, et al.
Published: (2020-09-01)

A KDM6A–KLF10 reinforcing feedback mechanism aggravates diabetic podocyte dysfunction
by: Chun‐Liang Lin, et al.
Published: (2019-04-01)

Abacavir enhances the efficacy of doxorubicin via inhibition of histone demethylase KDM5B in breast cancer
by: Anmi Jose, et al.
Published: (2025-08-01)

WCN25-226 KMT2D, a KABUKI SYNDROME DISEASE GENE AND EPIGENETIC REGULATOR, FUNCTIONS WITHIN NEPHROGENIC CELLS IN A CELL AUTONOMOUS MANNER TO CONTROL HUMAN AND MOUSE NEPHROGENESIS
by: Norman Rosenblum, et al.
Published: (2025-02-01)

Interaction Between PHF8 and a Segment of KDM2A, Which Is Controlled by the Phosphorylation Status at a Specific Serine in an Intrinsically Disordered Region of KDM2A, Regulates rRNA Transcription and Cell Proliferation in a Breast Cancer Cell Line
by: Kengo Okamoto, et al.
Published: (2025-05-01)

The NR_109/FUBP1/c-Myc axis regulates TAM polarization and remodels the tumor microenvironment to promote cancer development
by: Baoen Shan, et al.
Published: (2023-05-01)