Bone allograft impregnated with tobramycin and vancomycin delivers antibiotics in high concentrations for prophylaxis against bacteria commonly associated with prosthetic joint infections

Bone allograft impregnated with tobramycin and vancomycin delivers antibiotics in high concentrations for prophylaxis against bacteria commonly associated with prosthetic joint infections

ABSTRACT Local delivery of antibiotics as prophylaxis for prosthetic joint infections (PJIs) is frequently used during total hip replacement surgery. Morselized bone allograft impregnated with vancomycin and tobramycin (TobraVanc) could provide effective prophylaxis against bacteria commonly associa...

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Bibliographic Details
Main Authors: Björn Berglund, Daphne Wezenberg, Maud Nilsson, Bo Söderquist, Lennart E. Nilsson, Jörg Schilcher
Format: Article
Language:English
Published: American Society for Microbiology 2024-12-01
Series:Microbiology Spectrum
Subjects:
antibiotics
bone graft
prosthetic joint infection
prophylaxis
tobramycin
vancomycin
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00414-24
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