Blood metabolomic profile in patients with type 2 diabetes mellitus with diabetic peripheral neuropathic pain
ABSTRACT Aims This study aimed to identify metabolic markers for diabetic peripheral neuropathic pain (DPNP) in patients with type 2 diabetes mellitus (T2DM). Materials and Methods Blood metabolite levels in the amino acid, biogenic amine, sphingomyelin, phosphatidylcholine (PC), carnitines, and hex...
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| Format: | Article |
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Wiley
2025-02-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.14355 |
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| author | Hung‐Chou Kuo Chia‐Ni Lin Sung‐Sheng Tsai Chiung‐Mei Chen Rong‐Kuo Lyu Chun‐Che Chu Long‐Sun Ro Ming‐Feng Liao Hong‐Shiu Chang Yi‐Ching Weng Jawl‐Shan Hwang |
| author_facet | Hung‐Chou Kuo Chia‐Ni Lin Sung‐Sheng Tsai Chiung‐Mei Chen Rong‐Kuo Lyu Chun‐Che Chu Long‐Sun Ro Ming‐Feng Liao Hong‐Shiu Chang Yi‐Ching Weng Jawl‐Shan Hwang |
| author_sort | Hung‐Chou Kuo |
| collection | DOAJ |
| description | ABSTRACT Aims This study aimed to identify metabolic markers for diabetic peripheral neuropathic pain (DPNP) in patients with type 2 diabetes mellitus (T2DM). Materials and Methods Blood metabolite levels in the amino acid, biogenic amine, sphingomyelin, phosphatidylcholine (PC), carnitines, and hexose classes were analyzed in nondiabetic control (n = 27), T2DM without DPNP (n = 58), and T2DM with DPNP (n = 29) using liquid chromatography tandem mass spectrometry. Variable importance projection (VIP) evaluation by partial least squares discriminant analysis was performed on clinical parameters and metabolites. Results Sixteen variables with VIP > 1.0 (P < 0.05) were identified across all patient groups, and 5 variables were identified to discriminate between the two T2DM groups. DPNP patients showed elevated fasting blood glucose, glutamate, PC aa C36:1, lysoPC a C18:1, and lysoPC a C18:2, while low‐density lipoprotein cholesterol, phenylalanine, and tryptophan were reduced. Glutamate, lysoPC a C18:1, and lysoPC a C18:2 discriminated T2DM with DPNP from those without DPNP with an AUC of 0.671. The AUC was improved to 0.765 when ratios of metabolite pairs were considered. Interpretation Blood metabolites include glutamate, and phospholipid‐related metabolites implicated in neuropathic pain may have the potential as biomarkers for DPNP. Further investigation is required to understand the mechanism of action of these altered metabolites in DPNP. |
| format | Article |
| id | doaj-art-2451b9918388436ab7a7fd190d941ec5 |
| institution | Kabale University |
| issn | 2040-1116 2040-1124 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj-art-2451b9918388436ab7a7fd190d941ec52025-02-01T10:02:01ZengWileyJournal of Diabetes Investigation2040-11162040-11242025-02-0116224625610.1111/jdi.14355Blood metabolomic profile in patients with type 2 diabetes mellitus with diabetic peripheral neuropathic painHung‐Chou Kuo0Chia‐Ni Lin1Sung‐Sheng Tsai2Chiung‐Mei Chen3Rong‐Kuo Lyu4Chun‐Che Chu5Long‐Sun Ro6Ming‐Feng Liao7Hong‐Shiu Chang8Yi‐Ching Weng9Jawl‐Shan Hwang10Department of Neurology, Linkou Medical Center Chang Gung Memorial Hospital Taoyuan City TaiwanDepartment of Laboratory Medicine Chang Gung Memorial Hospital Taoyuan City TaiwanCollege of Medicine Chang Gung University Taoyuan City TaiwanDepartment of Neurology, Linkou Medical Center Chang Gung Memorial Hospital Taoyuan City TaiwanDepartment of Neurology, Linkou Medical Center Chang Gung Memorial Hospital Taoyuan City TaiwanDepartment of Neurology, Linkou Medical Center Chang Gung Memorial Hospital Taoyuan City TaiwanDepartment of Neurology, Linkou Medical Center Chang Gung Memorial Hospital Taoyuan City TaiwanDepartment of Neurology, Linkou Medical Center Chang Gung Memorial Hospital Taoyuan City TaiwanDepartment of Neurology, Linkou Medical Center Chang Gung Memorial Hospital Taoyuan City TaiwanDepartment of Neurology, Linkou Medical Center Chang Gung Memorial Hospital Taoyuan City TaiwanCollege of Medicine Chang Gung University Taoyuan City TaiwanABSTRACT Aims This study aimed to identify metabolic markers for diabetic peripheral neuropathic pain (DPNP) in patients with type 2 diabetes mellitus (T2DM). Materials and Methods Blood metabolite levels in the amino acid, biogenic amine, sphingomyelin, phosphatidylcholine (PC), carnitines, and hexose classes were analyzed in nondiabetic control (n = 27), T2DM without DPNP (n = 58), and T2DM with DPNP (n = 29) using liquid chromatography tandem mass spectrometry. Variable importance projection (VIP) evaluation by partial least squares discriminant analysis was performed on clinical parameters and metabolites. Results Sixteen variables with VIP > 1.0 (P < 0.05) were identified across all patient groups, and 5 variables were identified to discriminate between the two T2DM groups. DPNP patients showed elevated fasting blood glucose, glutamate, PC aa C36:1, lysoPC a C18:1, and lysoPC a C18:2, while low‐density lipoprotein cholesterol, phenylalanine, and tryptophan were reduced. Glutamate, lysoPC a C18:1, and lysoPC a C18:2 discriminated T2DM with DPNP from those without DPNP with an AUC of 0.671. The AUC was improved to 0.765 when ratios of metabolite pairs were considered. Interpretation Blood metabolites include glutamate, and phospholipid‐related metabolites implicated in neuropathic pain may have the potential as biomarkers for DPNP. Further investigation is required to understand the mechanism of action of these altered metabolites in DPNP.https://doi.org/10.1111/jdi.14355Diabetic peripheral neuropathic painMetabolomicsType 2 diabetes mellitus |
| spellingShingle | Hung‐Chou Kuo Chia‐Ni Lin Sung‐Sheng Tsai Chiung‐Mei Chen Rong‐Kuo Lyu Chun‐Che Chu Long‐Sun Ro Ming‐Feng Liao Hong‐Shiu Chang Yi‐Ching Weng Jawl‐Shan Hwang Blood metabolomic profile in patients with type 2 diabetes mellitus with diabetic peripheral neuropathic pain Journal of Diabetes Investigation Diabetic peripheral neuropathic pain Metabolomics Type 2 diabetes mellitus |
| title | Blood metabolomic profile in patients with type 2 diabetes mellitus with diabetic peripheral neuropathic pain |
| title_full | Blood metabolomic profile in patients with type 2 diabetes mellitus with diabetic peripheral neuropathic pain |
| title_fullStr | Blood metabolomic profile in patients with type 2 diabetes mellitus with diabetic peripheral neuropathic pain |
| title_full_unstemmed | Blood metabolomic profile in patients with type 2 diabetes mellitus with diabetic peripheral neuropathic pain |
| title_short | Blood metabolomic profile in patients with type 2 diabetes mellitus with diabetic peripheral neuropathic pain |
| title_sort | blood metabolomic profile in patients with type 2 diabetes mellitus with diabetic peripheral neuropathic pain |
| topic | Diabetic peripheral neuropathic pain Metabolomics Type 2 diabetes mellitus |
| url | https://doi.org/10.1111/jdi.14355 |
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