Meta-analysis of arterial spin labeling MRI to identify residual cerebral arteriovenous malformations after treatment
Abstract Background To use of statistical methods to assess the diagnostic value of arterial spin labeling (ASL) imaging for follow-up of treated arteriovenous malformations. Methods We screened references from four databases, namely, the Cochrane Library, PubMed, Web of Science and Embase, that met...
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BMC
2025-04-01
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| Series: | BMC Medical Imaging |
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| Online Access: | https://doi.org/10.1186/s12880-025-01668-3 |
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| author | Shurun Wan Xiuyan Yang Yudi Zhuo Fei Chen Peiyue He Weibo Luo Yi Shi Lingqun Zhu |
| author_facet | Shurun Wan Xiuyan Yang Yudi Zhuo Fei Chen Peiyue He Weibo Luo Yi Shi Lingqun Zhu |
| author_sort | Shurun Wan |
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| description | Abstract Background To use of statistical methods to assess the diagnostic value of arterial spin labeling (ASL) imaging for follow-up of treated arteriovenous malformations. Methods We screened references from four databases, namely, the Cochrane Library, PubMed, Web of Science and Embase, that met the requirements. The methodology quality of the included studies was evaluated using the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies-2) tool. Data pertaining to diagnostic performance were extracted, and the pooled sensitivity and specificity were calculated using a bivariate mixed-effects model. Results We included six studies with a total of 132 patients with arteriovenous malformation (AVM). The merged sensitivity and specificity of ASL for the diagnosis of brain AVMs with incomplete occlusion after treatment were 0.94[0.86–0.98] and 0.99 [0.59-1.00], respectively. According to the SROC curve summary, the AUC was found to be 0.98 [0.96–0.99]. No significant publication bias was observed. Conclusion While ASL does not currently match the diagnostic precision of DSA, it is instrumental in post-treatment surveillance of AVM patients. With the development of ASL technology in the future, this technique holds promise as a minimally invasive diagnostic strategy for AVMs with fewer side effects. Registration number of PROSPERO CRD42023422087. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-2450296d712a461cbef65784882ded01 |
| institution | OA Journals |
| issn | 1471-2342 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | BMC Medical Imaging |
| spelling | doaj-art-2450296d712a461cbef65784882ded012025-08-20T02:17:52ZengBMCBMC Medical Imaging1471-23422025-04-0125111110.1186/s12880-025-01668-3Meta-analysis of arterial spin labeling MRI to identify residual cerebral arteriovenous malformations after treatmentShurun Wan0Xiuyan Yang1Yudi Zhuo2Fei Chen3Peiyue He4Weibo Luo5Yi Shi6Lingqun Zhu7Key Laboratory of Chinese Internal Medicine of Educational Ministry and Beijing, Dongzhimen Hospital, Beijing University of Chinese MedicineSchool of Chinese Medicine, Beijing University of Chinese MedicineKey Laboratory of Chinese Internal Medicine of Educational Ministry and Beijing, Dongzhimen Hospital, Beijing University of Chinese MedicineDongzhimen Hospital, Beijing University of Chinese MedicineKey Laboratory of Chinese Internal Medicine of Educational Ministry and Beijing, Dongzhimen Hospital, Beijing University of Chinese MedicineKey Laboratory of Chinese Internal Medicine of Educational Ministry and Beijing, Dongzhimen Hospital, Beijing University of Chinese MedicineDongzhimen Hospital, Beijing University of Chinese MedicineKey Laboratory of Chinese Internal Medicine of Educational Ministry and Beijing, Dongzhimen Hospital, Beijing University of Chinese MedicineAbstract Background To use of statistical methods to assess the diagnostic value of arterial spin labeling (ASL) imaging for follow-up of treated arteriovenous malformations. Methods We screened references from four databases, namely, the Cochrane Library, PubMed, Web of Science and Embase, that met the requirements. The methodology quality of the included studies was evaluated using the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies-2) tool. Data pertaining to diagnostic performance were extracted, and the pooled sensitivity and specificity were calculated using a bivariate mixed-effects model. Results We included six studies with a total of 132 patients with arteriovenous malformation (AVM). The merged sensitivity and specificity of ASL for the diagnosis of brain AVMs with incomplete occlusion after treatment were 0.94[0.86–0.98] and 0.99 [0.59-1.00], respectively. According to the SROC curve summary, the AUC was found to be 0.98 [0.96–0.99]. No significant publication bias was observed. Conclusion While ASL does not currently match the diagnostic precision of DSA, it is instrumental in post-treatment surveillance of AVM patients. With the development of ASL technology in the future, this technique holds promise as a minimally invasive diagnostic strategy for AVMs with fewer side effects. Registration number of PROSPERO CRD42023422087. Clinical trial number Not applicable.https://doi.org/10.1186/s12880-025-01668-3Arterial spin labelingBrain arteriovenous malformationsMeta-analysis |
| spellingShingle | Shurun Wan Xiuyan Yang Yudi Zhuo Fei Chen Peiyue He Weibo Luo Yi Shi Lingqun Zhu Meta-analysis of arterial spin labeling MRI to identify residual cerebral arteriovenous malformations after treatment BMC Medical Imaging Arterial spin labeling Brain arteriovenous malformations Meta-analysis |
| title | Meta-analysis of arterial spin labeling MRI to identify residual cerebral arteriovenous malformations after treatment |
| title_full | Meta-analysis of arterial spin labeling MRI to identify residual cerebral arteriovenous malformations after treatment |
| title_fullStr | Meta-analysis of arterial spin labeling MRI to identify residual cerebral arteriovenous malformations after treatment |
| title_full_unstemmed | Meta-analysis of arterial spin labeling MRI to identify residual cerebral arteriovenous malformations after treatment |
| title_short | Meta-analysis of arterial spin labeling MRI to identify residual cerebral arteriovenous malformations after treatment |
| title_sort | meta analysis of arterial spin labeling mri to identify residual cerebral arteriovenous malformations after treatment |
| topic | Arterial spin labeling Brain arteriovenous malformations Meta-analysis |
| url | https://doi.org/10.1186/s12880-025-01668-3 |
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