Trifunctional Sialylation‐Based SF‐ZIF@NA Hydrogel for Selective Osteoclast Inhibition and Enhanced Bone‐Vessel Regeneration in Osteoporotic Bone Defects
Abstract Osteoporotic bone defects are challenging to repair due to imbalances in bone resorption and formation, coupled with insufficient vascularization. To address these issues, it develops a trifunctional hydrogel (SF‐ZIF@NA) designed to selectively inhibit osteoclast activity and enhance vascul...
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| Format: | Article |
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Wiley
2025-05-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202415895 |
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| author | Zhengrong Chen Wenxin Yang Yong Tang Qianqian Dong Kui Huang Jiulin Tan Jie Zhang Juan Cai Qixiu Yu Qijie Dai Jianzhong Xu Shuquan Guo Ce Dou Fei Luo |
| author_facet | Zhengrong Chen Wenxin Yang Yong Tang Qianqian Dong Kui Huang Jiulin Tan Jie Zhang Juan Cai Qixiu Yu Qijie Dai Jianzhong Xu Shuquan Guo Ce Dou Fei Luo |
| author_sort | Zhengrong Chen |
| collection | DOAJ |
| description | Abstract Osteoporotic bone defects are challenging to repair due to imbalances in bone resorption and formation, coupled with insufficient vascularization. To address these issues, it develops a trifunctional hydrogel (SF‐ZIF@NA) designed to selectively inhibit osteoclast activity and enhance vascularized bone regeneration. By enzymatically removing sialic acid, SF‐ZIF@NA prevents precursor osteoclasts (pOCs) from fusing into bone‐resorbing mature osteoclasts (mOCs), thereby preserving pOCs and their anabolic functions. Additionally, the hydrogel releases Zinc ion (Zn2⁺) in response to acidic conditions, promoting osteogenesis and angiogenesis. In vitro results confirmed that SF‐ZIF@NA impedes osteoclast fusion, enhances platelet‐derived growth factor‐BB (PDGF‐BB secretion from pOCs, and activates the FAK (focal adhesion kinase) signaling pathway to stimulate vascularized bone formation. In osteoporotic bone defect models, SF‐ZIF@NA accelerated bone repair with increased bone density and vascularization. These findings demonstrate that SF‐ZIF@NA offers a targeted and multifunctional strategy for osteoporotic bone regeneration by concurrently modulating osteoclast activity and promoting angiogenesis. |
| format | Article |
| id | doaj-art-244f5b74279a4095ad752d5e93f19c28 |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-244f5b74279a4095ad752d5e93f19c282025-08-20T01:52:42ZengWileyAdvanced Science2198-38442025-05-011219n/an/a10.1002/advs.202415895Trifunctional Sialylation‐Based SF‐ZIF@NA Hydrogel for Selective Osteoclast Inhibition and Enhanced Bone‐Vessel Regeneration in Osteoporotic Bone DefectsZhengrong Chen0Wenxin Yang1Yong Tang2Qianqian Dong3Kui Huang4Jiulin Tan5Jie Zhang6Juan Cai7Qixiu Yu8Qijie Dai9Jianzhong Xu10Shuquan Guo11Ce Dou12Fei Luo13Department of Orthopedics Southwest Hospital Third Military Medical University (Army Medical University) Chongqing 400038 ChinaDepartment of Orthopedics Southwest Hospital Third Military Medical University (Army Medical University) Chongqing 400038 ChinaDepartment of Orthopedics Southwest Hospital Third Military Medical University (Army Medical University) Chongqing 400038 ChinaIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City Biological Science Research Center Southwest University Chongqing 400716 ChinaDepartment of Orthopedics Southwest Hospital Third Military Medical University (Army Medical University) Chongqing 400038 ChinaDepartment of Orthopedics Southwest Hospital Third Military Medical University (Army Medical University) Chongqing 400038 ChinaDepartment of Orthopedics Southwest Hospital Third Military Medical University (Army Medical University) Chongqing 400038 ChinaDepartment of Orthopedics Southwest Hospital Third Military Medical University (Army Medical University) Chongqing 400038 ChinaDepartment of Orthopedics Southwest Hospital Third Military Medical University (Army Medical University) Chongqing 400038 ChinaDepartment of Orthopedics Southwest Hospital Third Military Medical University (Army Medical University) Chongqing 400038 ChinaDepartment of Orthopedics Southwest Hospital Third Military Medical University (Army Medical University) Chongqing 400038 ChinaDepartment of Orthopaedics The First Affiliated Hospital of Chongqing Medical University Chongqing 400042 ChinaDepartment of Orthopedics Southwest Hospital Third Military Medical University (Army Medical University) Chongqing 400038 ChinaDepartment of Orthopedics Southwest Hospital Third Military Medical University (Army Medical University) Chongqing 400038 ChinaAbstract Osteoporotic bone defects are challenging to repair due to imbalances in bone resorption and formation, coupled with insufficient vascularization. To address these issues, it develops a trifunctional hydrogel (SF‐ZIF@NA) designed to selectively inhibit osteoclast activity and enhance vascularized bone regeneration. By enzymatically removing sialic acid, SF‐ZIF@NA prevents precursor osteoclasts (pOCs) from fusing into bone‐resorbing mature osteoclasts (mOCs), thereby preserving pOCs and their anabolic functions. Additionally, the hydrogel releases Zinc ion (Zn2⁺) in response to acidic conditions, promoting osteogenesis and angiogenesis. In vitro results confirmed that SF‐ZIF@NA impedes osteoclast fusion, enhances platelet‐derived growth factor‐BB (PDGF‐BB secretion from pOCs, and activates the FAK (focal adhesion kinase) signaling pathway to stimulate vascularized bone formation. In osteoporotic bone defect models, SF‐ZIF@NA accelerated bone repair with increased bone density and vascularization. These findings demonstrate that SF‐ZIF@NA offers a targeted and multifunctional strategy for osteoporotic bone regeneration by concurrently modulating osteoclast activity and promoting angiogenesis.https://doi.org/10.1002/advs.202415895bone regenerationosteoporosispdgf‐bbsialylationvascularization |
| spellingShingle | Zhengrong Chen Wenxin Yang Yong Tang Qianqian Dong Kui Huang Jiulin Tan Jie Zhang Juan Cai Qixiu Yu Qijie Dai Jianzhong Xu Shuquan Guo Ce Dou Fei Luo Trifunctional Sialylation‐Based SF‐ZIF@NA Hydrogel for Selective Osteoclast Inhibition and Enhanced Bone‐Vessel Regeneration in Osteoporotic Bone Defects Advanced Science bone regeneration osteoporosis pdgf‐bb sialylation vascularization |
| title | Trifunctional Sialylation‐Based SF‐ZIF@NA Hydrogel for Selective Osteoclast Inhibition and Enhanced Bone‐Vessel Regeneration in Osteoporotic Bone Defects |
| title_full | Trifunctional Sialylation‐Based SF‐ZIF@NA Hydrogel for Selective Osteoclast Inhibition and Enhanced Bone‐Vessel Regeneration in Osteoporotic Bone Defects |
| title_fullStr | Trifunctional Sialylation‐Based SF‐ZIF@NA Hydrogel for Selective Osteoclast Inhibition and Enhanced Bone‐Vessel Regeneration in Osteoporotic Bone Defects |
| title_full_unstemmed | Trifunctional Sialylation‐Based SF‐ZIF@NA Hydrogel for Selective Osteoclast Inhibition and Enhanced Bone‐Vessel Regeneration in Osteoporotic Bone Defects |
| title_short | Trifunctional Sialylation‐Based SF‐ZIF@NA Hydrogel for Selective Osteoclast Inhibition and Enhanced Bone‐Vessel Regeneration in Osteoporotic Bone Defects |
| title_sort | trifunctional sialylation based sf zif na hydrogel for selective osteoclast inhibition and enhanced bone vessel regeneration in osteoporotic bone defects |
| topic | bone regeneration osteoporosis pdgf‐bb sialylation vascularization |
| url | https://doi.org/10.1002/advs.202415895 |
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