CXCL12 chemokine dimer signaling modulates acute myelogenous leukemia cell migration through altered receptor internalization

CXCL12 chemokine dimer signaling modulates acute myelogenous leukemia cell migration through altered receptor internalization

Abstract Acute myeloid leukemia (AML) is a malignancy of immature myeloid blast cells with stem-like and chemoresistant cells being retained in the bone marrow through CXCL12-CXCR4 signaling. Current CXCR4 inhibitors that mobilize AML cells into the bloodstream have failed to improve patient surviva...

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Bibliographic Details
Main Authors: Donovan Drouillard, Michael Halyko, Elizabeth Cinquegrani, Maria Poimenidou, Miracle Emosivbe, Donna McAllister, Francis C. Peterson, Adriano Marchese, Michael B. Dwinell
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Chemokines
CXCR4
Acute myeloid leukemia
GPCR
Receptor internalization
Cell signaling
Online Access:https://doi.org/10.1038/s41598-025-12005-7
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