Tumor thickness and depth of invasion in squamous cell carcinoma of tongue as indicators of the loco-regional spread of the disease: A preliminary study
Background: Magnetic resonance imaging (MRI) is a routinely used imaging modality for pre-treatment radiologic evaluation of tongue carcinoma, providing accurate information regarding the extent of the disease. Aims and objectives: To investigate the role of MRI-derived depth of invasion and tumor t...
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Elsevier
2024-07-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426824000812 |
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| author | Rupsa Das Satya Ranjan Misra Satya Sundar Gajendra Mohapatra Pravakar Bahinipati Smita Rani Priyadarshini Alkananda Sahoo Debahuti Mishra Anamika Rai |
| author_facet | Rupsa Das Satya Ranjan Misra Satya Sundar Gajendra Mohapatra Pravakar Bahinipati Smita Rani Priyadarshini Alkananda Sahoo Debahuti Mishra Anamika Rai |
| author_sort | Rupsa Das |
| collection | DOAJ |
| description | Background: Magnetic resonance imaging (MRI) is a routinely used imaging modality for pre-treatment radiologic evaluation of tongue carcinoma, providing accurate information regarding the extent of the disease. Aims and objectives: To investigate the role of MRI-derived depth of invasion and tumor thickness evaluation in squamous cell carcinoma of the tongue, and to assess if any correlation exists between depth of invasion, tumor thickness, nodal metastasis, muscles, and space involved. Materials and methods: Thirty-three patients with oral squamous cell carcinoma of the tongue who had undergone pre-treatment MRI and excisional biopsy were included. The tumor thickness (TT) and depth of invasion (DOI) were evaluated on MRI and histopathologic images. Result: The relation between different methodologies for assessing showed a very high correlation for the tumor tissue thickness (r = 0.99, p < 0.05) and depth of invasion (r = 0.82, p < 0.05). The tumor thickness and the depth of invasion increased with the loss of differentiation in the carcinoma histopathologically. As the depth of invasion increases, the extent of the spread of the carcinoma to tongue musculature, lingual septum, and spaces also increases. Conclusion: The present study has depicted a high correlation between the tumor thickness and the depth of invasion between MRI and histopathological findings and is the first of its kind to correlate DOI to the invasiveness of the disease. |
| format | Article |
| id | doaj-art-2446fc2e06954ca6ac0073ec2a8893d9 |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-2446fc2e06954ca6ac0073ec2a8893d92025-01-24T04:45:04ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682024-07-01144423429Tumor thickness and depth of invasion in squamous cell carcinoma of tongue as indicators of the loco-regional spread of the disease: A preliminary studyRupsa Das0Satya Ranjan Misra1Satya Sundar Gajendra Mohapatra2Pravakar Bahinipati3Smita Rani Priyadarshini4Alkananda Sahoo5Debahuti Mishra6Anamika Rai7Department of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan deemed to be University, Bhubaneswar, Odish, IndiaDepartment of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan deemed to be University, Bhubaneswar, Odish, India; Corresponding author. Department of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan deemed to be University, K-8 Kalinga Nagar, Ghatikia, Bhubaneswar 751003, Odisha, India.Department of Radiodiagnosis, Institute of Medical Sciences, Siksha ‘O’ Anusandhan deemed to be University, Bhubaneswar, Odisha, IndiaDepartment of Radiodiagnosis, Institute of Medical Sciences, Siksha ‘O’ Anusandhan deemed to be University, Bhubaneswar, Odisha, IndiaDepartment of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan deemed to be University, Bhubaneswar, Odish, IndiaDepartment of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan deemed to be University, Bhubaneswar, Odish, IndiaDepartment of Pathology, Institute of Medical Sciences, Siksha ‘O’ Anusandhan deemed to be University, Bhubaneswar, Odisha, IndiaDepartment of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan deemed to be University, Bhubaneswar, Odish, IndiaBackground: Magnetic resonance imaging (MRI) is a routinely used imaging modality for pre-treatment radiologic evaluation of tongue carcinoma, providing accurate information regarding the extent of the disease. Aims and objectives: To investigate the role of MRI-derived depth of invasion and tumor thickness evaluation in squamous cell carcinoma of the tongue, and to assess if any correlation exists between depth of invasion, tumor thickness, nodal metastasis, muscles, and space involved. Materials and methods: Thirty-three patients with oral squamous cell carcinoma of the tongue who had undergone pre-treatment MRI and excisional biopsy were included. The tumor thickness (TT) and depth of invasion (DOI) were evaluated on MRI and histopathologic images. Result: The relation between different methodologies for assessing showed a very high correlation for the tumor tissue thickness (r = 0.99, p < 0.05) and depth of invasion (r = 0.82, p < 0.05). The tumor thickness and the depth of invasion increased with the loss of differentiation in the carcinoma histopathologically. As the depth of invasion increases, the extent of the spread of the carcinoma to tongue musculature, lingual septum, and spaces also increases. Conclusion: The present study has depicted a high correlation between the tumor thickness and the depth of invasion between MRI and histopathological findings and is the first of its kind to correlate DOI to the invasiveness of the disease.http://www.sciencedirect.com/science/article/pii/S2212426824000812Depth of invasionHistopathologyMagnetic resonance imagingPrognostic markerTongue carcinomaTumor thickness |
| spellingShingle | Rupsa Das Satya Ranjan Misra Satya Sundar Gajendra Mohapatra Pravakar Bahinipati Smita Rani Priyadarshini Alkananda Sahoo Debahuti Mishra Anamika Rai Tumor thickness and depth of invasion in squamous cell carcinoma of tongue as indicators of the loco-regional spread of the disease: A preliminary study Journal of Oral Biology and Craniofacial Research Depth of invasion Histopathology Magnetic resonance imaging Prognostic marker Tongue carcinoma Tumor thickness |
| title | Tumor thickness and depth of invasion in squamous cell carcinoma of tongue as indicators of the loco-regional spread of the disease: A preliminary study |
| title_full | Tumor thickness and depth of invasion in squamous cell carcinoma of tongue as indicators of the loco-regional spread of the disease: A preliminary study |
| title_fullStr | Tumor thickness and depth of invasion in squamous cell carcinoma of tongue as indicators of the loco-regional spread of the disease: A preliminary study |
| title_full_unstemmed | Tumor thickness and depth of invasion in squamous cell carcinoma of tongue as indicators of the loco-regional spread of the disease: A preliminary study |
| title_short | Tumor thickness and depth of invasion in squamous cell carcinoma of tongue as indicators of the loco-regional spread of the disease: A preliminary study |
| title_sort | tumor thickness and depth of invasion in squamous cell carcinoma of tongue as indicators of the loco regional spread of the disease a preliminary study |
| topic | Depth of invasion Histopathology Magnetic resonance imaging Prognostic marker Tongue carcinoma Tumor thickness |
| url | http://www.sciencedirect.com/science/article/pii/S2212426824000812 |
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