The Role of Immunosenescence in Neurodegenerative Diseases
Aging is characterized by the progressive decline of physiological function and tissue homeostasis leading to increased vulnerability, degeneration, and death. Aging-related changes of the innate and adaptive immune system include decline in the preservation and enhancement of many immune functions,...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/6039171 |
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| _version_ | 1849306912975224832 |
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| author | Erica Costantini Chiara D’Angelo Marcella Reale |
| author_facet | Erica Costantini Chiara D’Angelo Marcella Reale |
| author_sort | Erica Costantini |
| collection | DOAJ |
| description | Aging is characterized by the progressive decline of physiological function and tissue homeostasis leading to increased vulnerability, degeneration, and death. Aging-related changes of the innate and adaptive immune system include decline in the preservation and enhancement of many immune functions, such as changes in the number of circulating monocytic and dendritic cells, thymic involution, T cell polyfunctionality, or production of proinflammatory cytokines, and are defined as immunosenescence. Inflammatory functions are increased with age, causing the chronic low-grade inflammation, referred to as inflamm-aging, that contribute, together with immunosenescence, to neurodegenerative diseases. In this review, we discuss the link between the immune and nervous systems and how the immunosenescence and inflamm-aging can contribute to neurodegenerative diseases. |
| format | Article |
| id | doaj-art-24434f8a75574925abf56ee03deda16a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-24434f8a75574925abf56ee03deda16a2025-08-20T03:54:56ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/60391716039171The Role of Immunosenescence in Neurodegenerative DiseasesErica Costantini0Chiara D’Angelo1Marcella Reale2Unit of Immunodiagnostic and Molecular Pathology, Department of Medical, Oral and Biotechnological Sciences, “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyUnit of Immunodiagnostic and Molecular Pathology, Department of Medical, Oral and Biotechnological Sciences, “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyUnit of Immunodiagnostic and Molecular Pathology, Department of Medical, Oral and Biotechnological Sciences, “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyAging is characterized by the progressive decline of physiological function and tissue homeostasis leading to increased vulnerability, degeneration, and death. Aging-related changes of the innate and adaptive immune system include decline in the preservation and enhancement of many immune functions, such as changes in the number of circulating monocytic and dendritic cells, thymic involution, T cell polyfunctionality, or production of proinflammatory cytokines, and are defined as immunosenescence. Inflammatory functions are increased with age, causing the chronic low-grade inflammation, referred to as inflamm-aging, that contribute, together with immunosenescence, to neurodegenerative diseases. In this review, we discuss the link between the immune and nervous systems and how the immunosenescence and inflamm-aging can contribute to neurodegenerative diseases.http://dx.doi.org/10.1155/2018/6039171 |
| spellingShingle | Erica Costantini Chiara D’Angelo Marcella Reale The Role of Immunosenescence in Neurodegenerative Diseases Mediators of Inflammation |
| title | The Role of Immunosenescence in Neurodegenerative Diseases |
| title_full | The Role of Immunosenescence in Neurodegenerative Diseases |
| title_fullStr | The Role of Immunosenescence in Neurodegenerative Diseases |
| title_full_unstemmed | The Role of Immunosenescence in Neurodegenerative Diseases |
| title_short | The Role of Immunosenescence in Neurodegenerative Diseases |
| title_sort | role of immunosenescence in neurodegenerative diseases |
| url | http://dx.doi.org/10.1155/2018/6039171 |
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