Terminal complement complex deposition on chondrocytes promotes premature senescence in age- and trauma-related osteoarthritis

Terminal complement complex deposition on chondrocytes promotes premature senescence in age- and trauma-related osteoarthritis

BackgroundThe complement system is locally activated after joint injuries and leads to the deposition of the terminal complement complex (TCC). Sublytic TCC deposition is associated with phenotypical alterations of human articular chondrocytes (hAC) and enhanced release of inflammatory cytokines. Ch...

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Bibliographic Details
Main Authors: Leonie Ruths, Jana Hengge, Graciosa Q. Teixeira, Melanie Haffner-Luntzer, Anita Ignatius, Jana Riegger
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
osteoarthritis
complement system
terminal complement complex
senescence
interleukin-6
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1470907/full
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