Parameters of the Component Composition of the Body and Their Relationship with the Development of Ascites in Liver Cirrhosis
Aim: to evaluate the relationship of body composition components with the development of ascites in patients with liver cirrhosis.Materials and methods. One hundred and ten patients (44 men and 66 women) with the established diagnosis of liver cirrhosis were treated at the University Clinical Hospit...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2024-08-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/898 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860033005289472 |
|---|---|
| author | Yu. O. Zharikov M. S. Zharkova A. N. Gadjiakhmedova A. M. Aliyeva V. N. Nikolenko V. T. Ivashkin |
| author_facet | Yu. O. Zharikov M. S. Zharkova A. N. Gadjiakhmedova A. M. Aliyeva V. N. Nikolenko V. T. Ivashkin |
| author_sort | Yu. O. Zharikov |
| collection | DOAJ |
| description | Aim: to evaluate the relationship of body composition components with the development of ascites in patients with liver cirrhosis.Materials and methods. One hundred and ten patients (44 men and 66 women) with the established diagnosis of liver cirrhosis were treated at the University Clinical Hospital No 2 of the Sechenov University. The assessment of the component composition of the patients’ body was carried out using the ABC-01 “MEDASS” device (“MEDASS”, Russia). Ascites diagnosis was performed using ultrasound examination of the abdominal cavity and retroperitoneal space.Results. The values of body mass index (p < 0.001), fat mass (p = 0.002), active cell mass (p < 0.001), and phase angle (p < 0.001) were lower in patients with ascites than without it. Patients with a lower percentage of body fat mass had a more severe ascites severity and vice versa, and the proportion of fat mass was generally higher in women than in men (r = –0.290; p = 0.002). Patients with lower active cell mass had higher ascites severity (r = –0.380; p < 0.001). However, this indicator was lower in women than in men. Significant negative correlations were revealed between fat mass, active cell mass, phase angle (r = –0.395; p < 0.001) and the severity of ascites.Conclusion. Our study confirms the importance of body composition parameters in the development of ascites in patients with cirrhosis of the liver. Insufficient amount of fat and muscle mass, as well as low values of the phase angle according to the results of bioimpedance can become predictors of the development of ascites. Evaluation of these components can be used in prognostic models to identify patients with an increased risk of ascites. Further research in this area will help to better understand the mechanisms of ascites development and develop effective methods of prevention and treatment of this complication in patients with liver cirrhosis. |
| format | Article |
| id | doaj-art-243ec7e620844fdd91b4871cb3ef08e7 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2024-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-243ec7e620844fdd91b4871cb3ef08e72025-02-10T16:14:39ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732024-08-01343536110.22416/1382-4376-2024-34-3-53-61817Parameters of the Component Composition of the Body and Their Relationship with the Development of Ascites in Liver CirrhosisYu. O. Zharikov0M. S. Zharkova1A. N. Gadjiakhmedova2A. M. Aliyeva3V. N. Nikolenko4V. T. Ivashkin5I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State UniversityI.M. Sechenov First Moscow State Medical University (Sechenov University)Aim: to evaluate the relationship of body composition components with the development of ascites in patients with liver cirrhosis.Materials and methods. One hundred and ten patients (44 men and 66 women) with the established diagnosis of liver cirrhosis were treated at the University Clinical Hospital No 2 of the Sechenov University. The assessment of the component composition of the patients’ body was carried out using the ABC-01 “MEDASS” device (“MEDASS”, Russia). Ascites diagnosis was performed using ultrasound examination of the abdominal cavity and retroperitoneal space.Results. The values of body mass index (p < 0.001), fat mass (p = 0.002), active cell mass (p < 0.001), and phase angle (p < 0.001) were lower in patients with ascites than without it. Patients with a lower percentage of body fat mass had a more severe ascites severity and vice versa, and the proportion of fat mass was generally higher in women than in men (r = –0.290; p = 0.002). Patients with lower active cell mass had higher ascites severity (r = –0.380; p < 0.001). However, this indicator was lower in women than in men. Significant negative correlations were revealed between fat mass, active cell mass, phase angle (r = –0.395; p < 0.001) and the severity of ascites.Conclusion. Our study confirms the importance of body composition parameters in the development of ascites in patients with cirrhosis of the liver. Insufficient amount of fat and muscle mass, as well as low values of the phase angle according to the results of bioimpedance can become predictors of the development of ascites. Evaluation of these components can be used in prognostic models to identify patients with an increased risk of ascites. Further research in this area will help to better understand the mechanisms of ascites development and develop effective methods of prevention and treatment of this complication in patients with liver cirrhosis.https://www.gastro-j.ru/jour/article/view/898bioimpedance analysisfat massmuscle massascitesliver cirrhosis |
| spellingShingle | Yu. O. Zharikov M. S. Zharkova A. N. Gadjiakhmedova A. M. Aliyeva V. N. Nikolenko V. T. Ivashkin Parameters of the Component Composition of the Body and Their Relationship with the Development of Ascites in Liver Cirrhosis Российский журнал гастроэнтерологии, гепатологии, колопроктологии bioimpedance analysis fat mass muscle mass ascites liver cirrhosis |
| title | Parameters of the Component Composition of the Body and Their Relationship with the Development of Ascites in Liver Cirrhosis |
| title_full | Parameters of the Component Composition of the Body and Their Relationship with the Development of Ascites in Liver Cirrhosis |
| title_fullStr | Parameters of the Component Composition of the Body and Their Relationship with the Development of Ascites in Liver Cirrhosis |
| title_full_unstemmed | Parameters of the Component Composition of the Body and Their Relationship with the Development of Ascites in Liver Cirrhosis |
| title_short | Parameters of the Component Composition of the Body and Their Relationship with the Development of Ascites in Liver Cirrhosis |
| title_sort | parameters of the component composition of the body and their relationship with the development of ascites in liver cirrhosis |
| topic | bioimpedance analysis fat mass muscle mass ascites liver cirrhosis |
| url | https://www.gastro-j.ru/jour/article/view/898 |
| work_keys_str_mv | AT yuozharikov parametersofthecomponentcompositionofthebodyandtheirrelationshipwiththedevelopmentofascitesinlivercirrhosis AT mszharkova parametersofthecomponentcompositionofthebodyandtheirrelationshipwiththedevelopmentofascitesinlivercirrhosis AT angadjiakhmedova parametersofthecomponentcompositionofthebodyandtheirrelationshipwiththedevelopmentofascitesinlivercirrhosis AT amaliyeva parametersofthecomponentcompositionofthebodyandtheirrelationshipwiththedevelopmentofascitesinlivercirrhosis AT vnnikolenko parametersofthecomponentcompositionofthebodyandtheirrelationshipwiththedevelopmentofascitesinlivercirrhosis AT vtivashkin parametersofthecomponentcompositionofthebodyandtheirrelationshipwiththedevelopmentofascitesinlivercirrhosis |