A review on the bioactive compounds of Rhus chinensis Mill. native to the Sikkim Himalayas
Background: The Sikkim Himalaya is home to the wild medicinal shrub Rhus chinensis Mill, which produces edible fruits. Traditionally, the fruit juice concentrate has been used to treat a variety of stomach issues. The plant is rich in phytoconstituents, including gallic acid (up to 130.4 ± 2.5 mg/g)...
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Creative Pharma Assent
2025-06-01
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| Series: | Journal of Applied Pharmaceutical Research |
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| author | Sujan Banerjee Bhupendra Shrestha Surabhi Mandal |
| author_facet | Sujan Banerjee Bhupendra Shrestha Surabhi Mandal |
| author_sort | Sujan Banerjee |
| collection | DOAJ |
| description | Background: The Sikkim Himalaya is home to the wild medicinal shrub Rhus chinensis Mill, which produces edible fruits. Traditionally, the fruit juice concentrate has been used to treat a variety of stomach issues. The plant is rich in phytoconstituents, including gallic acid (up to 130.4 ± 2.5 mg/g), methyl gallate, flavonoids, and tannins, which contribute to its traditional applications in managing conditions such as diarrhoea, dysentery, toothache, cough, and wounds. The total flavonoids and flavonol levels were quantified as rutin equivalents. The total phenolics were calculated as gallic acid equivalents. Through various in vitro antioxidant methods, including DPPH, Total antioxidant content, ABTS, and Hydrogen peroxide scavenging assays, the antioxidant capacity was determined. Methodology: This review combines data from numerous research studies and review articles that have elaborated on the various phytoconstituents, medicinal uses, and pharmacological properties of different Rhus species. Results and Discussion: This review provides a detailed description of multiple phytoconstituents, traditional uses, and medicinal applications of Rhus species. The quantitative findings from previous studies report the total phenolic content as 123.52±1.29 mg GAE/g. IC50 values through DPPH free radical scavenging assay and Hydrogen scavenging assay were 42.69±0.1% and 63.20±1.48% respectively. Conclusion: This review provides an in-depth description of various phytoconstituents, including gallic acid, citric acid, myricetin-3-O-rhamnoside, methyl gallate, quercetin-3-O-arabinoside, and protocatechuic acid, among others. These results provide concrete evidence to support the potential of Rhus chinensis Mill. as a source of bioactive compounds for the creation of new treatments. |
| format | Article |
| id | doaj-art-243ac43951414fc0bd9e4e85591fa97d |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-06-01 |
| publisher | Creative Pharma Assent |
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| series | Journal of Applied Pharmaceutical Research |
| spelling | doaj-art-243ac43951414fc0bd9e4e85591fa97d2025-08-20T03:38:59ZengCreative Pharma AssentJournal of Applied Pharmaceutical Research2348-03352025-06-01133657510.69857/joapr.v13i3.897898A review on the bioactive compounds of Rhus chinensis Mill. native to the Sikkim HimalayasSujan Banerjee0Bhupendra Shrestha1Surabhi Mandal2Department of Pharmaceutical Analysis, Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim, 737136, IndiaDepartment of Pharmaceutical Analysis, Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim, 737136, IndiaDepartment of Pharmaceutical Analysis, Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim, 737136, IndiaBackground: The Sikkim Himalaya is home to the wild medicinal shrub Rhus chinensis Mill, which produces edible fruits. Traditionally, the fruit juice concentrate has been used to treat a variety of stomach issues. The plant is rich in phytoconstituents, including gallic acid (up to 130.4 ± 2.5 mg/g), methyl gallate, flavonoids, and tannins, which contribute to its traditional applications in managing conditions such as diarrhoea, dysentery, toothache, cough, and wounds. The total flavonoids and flavonol levels were quantified as rutin equivalents. The total phenolics were calculated as gallic acid equivalents. Through various in vitro antioxidant methods, including DPPH, Total antioxidant content, ABTS, and Hydrogen peroxide scavenging assays, the antioxidant capacity was determined. Methodology: This review combines data from numerous research studies and review articles that have elaborated on the various phytoconstituents, medicinal uses, and pharmacological properties of different Rhus species. Results and Discussion: This review provides a detailed description of multiple phytoconstituents, traditional uses, and medicinal applications of Rhus species. The quantitative findings from previous studies report the total phenolic content as 123.52±1.29 mg GAE/g. IC50 values through DPPH free radical scavenging assay and Hydrogen scavenging assay were 42.69±0.1% and 63.20±1.48% respectively. Conclusion: This review provides an in-depth description of various phytoconstituents, including gallic acid, citric acid, myricetin-3-O-rhamnoside, methyl gallate, quercetin-3-O-arabinoside, and protocatechuic acid, among others. These results provide concrete evidence to support the potential of Rhus chinensis Mill. as a source of bioactive compounds for the creation of new treatments.https://japtronline.com/index.php/joapr/article/view/897rhus chinensis mill.hepatoprotectiveanti-inflammatoryanti-oxidantantidiarrheal |
| spellingShingle | Sujan Banerjee Bhupendra Shrestha Surabhi Mandal A review on the bioactive compounds of Rhus chinensis Mill. native to the Sikkim Himalayas Journal of Applied Pharmaceutical Research rhus chinensis mill. hepatoprotective anti-inflammatory anti-oxidant antidiarrheal |
| title | A review on the bioactive compounds of Rhus chinensis Mill. native to the Sikkim Himalayas |
| title_full | A review on the bioactive compounds of Rhus chinensis Mill. native to the Sikkim Himalayas |
| title_fullStr | A review on the bioactive compounds of Rhus chinensis Mill. native to the Sikkim Himalayas |
| title_full_unstemmed | A review on the bioactive compounds of Rhus chinensis Mill. native to the Sikkim Himalayas |
| title_short | A review on the bioactive compounds of Rhus chinensis Mill. native to the Sikkim Himalayas |
| title_sort | review on the bioactive compounds of rhus chinensis mill native to the sikkim himalayas |
| topic | rhus chinensis mill. hepatoprotective anti-inflammatory anti-oxidant antidiarrheal |
| url | https://japtronline.com/index.php/joapr/article/view/897 |
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