Determination of nutrition index and correlation with activity of lupus nephritis
Background/Aim. Lupus nephritis (LN), as an immuno-inflammatory kidney lesion and the most severe manifestation of systemic lupus erythematosus (SLE), is accompanied by a disorder of nutritional status of patients. The aim of our study was to determine the importance of parameters of nutritional sta...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2024-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | https://doiserbia.nb.rs/img/doi/0042-8450/2024/0042-84502400017R.pdf |
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| author | Rabrenović Violeta Petrović Milica Rabrenović Milorad Rančić Nemanja |
| author_facet | Rabrenović Violeta Petrović Milica Rabrenović Milorad Rančić Nemanja |
| author_sort | Rabrenović Violeta |
| collection | DOAJ |
| description | Background/Aim. Lupus nephritis (LN), as an immuno-inflammatory kidney lesion and the most severe manifestation of systemic lupus erythematosus (SLE), is accompanied by a disorder of nutritional status of patients. The aim of our study was to determine the importance of parameters of nutritional status [nutritional risk index (NRI), prognostic nutritional index (PNI), and Controlling Nutritional Status (CONUT)] and their association with standard parameters of LN activity. Methods. The clinical study included a group of 92 participants: 67 patients with LN (34 patients had LN active disease – the LNa group, and 33 patients were in LN remission – the LNr group) and 25 healthy subjects in the control group. In addition to standard laboratory parameters and LN activity parameters, derived parameters were also determined: PNI = 10 × serum albumin value (g/dL) + 0.005 × total lymphocyte count/mm3; N RI = 1 .519 × serum albumin value (g/dL) + 41.7 × present weight (kg)/usual body weight (defined as stable body weight for last six months) (kg); CONUT score = serum albumin value (g/dL) + total lymphocyte count/mm3 + total cholesterol level (mmol/L). Results. A statistically significant difference between all three groups was observed for the PNI (p = 0.001) and the CONUT score (p = 0.000), while there was no significant difference for NRI. In the LNa group, a statistically significant correlation was found for PNI in relation to albumin, complement C 3 and C 4, and a statistically significant negative correlation with the level of anti-double stranded (ds) DNA antibodies (Abs). NRI had a statistically significant correlation only with proteinuria in the LNa group. CONUT showed significant correlations with most of the parameters of disease activity: negative correlation with albumin and complement C3 (p = 0.000), and positive correlation with anti-dsDNA Abs (p = 0.002), Systemic Lupus Erythematosus Disease Activity Index/renal (SLEDAI/r), and proteinuria g/24 hrs (p = 0.000). Conclusion. A statistically significant difference was observed between the groups for the nutrition score CONUT and the PNI. Their correlation with standard parameters of active disease was significant for most parameters in the group of patients with LNa. |
| format | Article |
| id | doaj-art-2437c62129734e18b54ee42b5446f932 |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-2437c62129734e18b54ee42b5446f9322025-08-20T02:04:41ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202024-01-0181526226810.2298/VSP240103017R0042-84502400017RDetermination of nutrition index and correlation with activity of lupus nephritisRabrenović Violeta0Petrović Milica1Rabrenović Milorad2Rančić Nemanja3https://orcid.org/0000-0002-5122-8094Military Medical Academy, Clinic for Nephrology, Belgrade, Serbia + University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, SerbiaMilitary Medical Academy, Clinic for Nephrology, Belgrade, SerbiaMilitary Medical Academy, Center for Hyperbaric Medicine, Belgrade, SerbiaUniversity of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, Serbia + Military Medical Academy, Center for Clinical Pharmacology, Belgrade, SerbiaBackground/Aim. Lupus nephritis (LN), as an immuno-inflammatory kidney lesion and the most severe manifestation of systemic lupus erythematosus (SLE), is accompanied by a disorder of nutritional status of patients. The aim of our study was to determine the importance of parameters of nutritional status [nutritional risk index (NRI), prognostic nutritional index (PNI), and Controlling Nutritional Status (CONUT)] and their association with standard parameters of LN activity. Methods. The clinical study included a group of 92 participants: 67 patients with LN (34 patients had LN active disease – the LNa group, and 33 patients were in LN remission – the LNr group) and 25 healthy subjects in the control group. In addition to standard laboratory parameters and LN activity parameters, derived parameters were also determined: PNI = 10 × serum albumin value (g/dL) + 0.005 × total lymphocyte count/mm3; N RI = 1 .519 × serum albumin value (g/dL) + 41.7 × present weight (kg)/usual body weight (defined as stable body weight for last six months) (kg); CONUT score = serum albumin value (g/dL) + total lymphocyte count/mm3 + total cholesterol level (mmol/L). Results. A statistically significant difference between all three groups was observed for the PNI (p = 0.001) and the CONUT score (p = 0.000), while there was no significant difference for NRI. In the LNa group, a statistically significant correlation was found for PNI in relation to albumin, complement C 3 and C 4, and a statistically significant negative correlation with the level of anti-double stranded (ds) DNA antibodies (Abs). NRI had a statistically significant correlation only with proteinuria in the LNa group. CONUT showed significant correlations with most of the parameters of disease activity: negative correlation with albumin and complement C3 (p = 0.000), and positive correlation with anti-dsDNA Abs (p = 0.002), Systemic Lupus Erythematosus Disease Activity Index/renal (SLEDAI/r), and proteinuria g/24 hrs (p = 0.000). Conclusion. A statistically significant difference was observed between the groups for the nutrition score CONUT and the PNI. Their correlation with standard parameters of active disease was significant for most parameters in the group of patients with LNa.https://doiserbia.nb.rs/img/doi/0042-8450/2024/0042-84502400017R.pdfautoimmune diseaseslupus erythematosus, systemiclupus nephritisnutritional status |
| spellingShingle | Rabrenović Violeta Petrović Milica Rabrenović Milorad Rančić Nemanja Determination of nutrition index and correlation with activity of lupus nephritis Vojnosanitetski Pregled autoimmune diseases lupus erythematosus, systemic lupus nephritis nutritional status |
| title | Determination of nutrition index and correlation with activity of lupus nephritis |
| title_full | Determination of nutrition index and correlation with activity of lupus nephritis |
| title_fullStr | Determination of nutrition index and correlation with activity of lupus nephritis |
| title_full_unstemmed | Determination of nutrition index and correlation with activity of lupus nephritis |
| title_short | Determination of nutrition index and correlation with activity of lupus nephritis |
| title_sort | determination of nutrition index and correlation with activity of lupus nephritis |
| topic | autoimmune diseases lupus erythematosus, systemic lupus nephritis nutritional status |
| url | https://doiserbia.nb.rs/img/doi/0042-8450/2024/0042-84502400017R.pdf |
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