Chrysophanol from the Roots of Kniphofia Insignis and Evaluation of Its Antibacterial Activities

Sequential extraction of the roots of Kniphofia insignis using cold maceration techniques and column chromatographic separation leads to the isolation of one monomeric anthraquinone, chrysophanol (1). The structure of the compound was established using spectroscopic analyses including NMR (1H and 13...

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Main Authors: Asnakew Amare Tadesse, Beshir Legas Muhammed, Moges Abebe Zeleke
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2022/5884309
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author Asnakew Amare Tadesse
Beshir Legas Muhammed
Moges Abebe Zeleke
author_facet Asnakew Amare Tadesse
Beshir Legas Muhammed
Moges Abebe Zeleke
author_sort Asnakew Amare Tadesse
collection DOAJ
description Sequential extraction of the roots of Kniphofia insignis using cold maceration techniques and column chromatographic separation leads to the isolation of one monomeric anthraquinone, chrysophanol (1). The structure of the compound was established using spectroscopic analyses including NMR (1H and 13C-NMR, infrared) and comparison with reported literature. The in vitro antibacterial activities of the crude extracts and the isolated compounds were evaluated against four bacterial strains (S. aureus ATCC 25923, B. subtilis ATCC 6633, E. coli ATCC 35218, and P. aeruginosa ATCC 27853). Among them, the crude extract, acetone extract, has shown substantial antibacterial activity with the highest activity against E. coli (22.3 mm). However, compound 1 has a better zone of inhibition with 19.3 mm against P. aeruginosa.
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institution Kabale University
issn 2090-9071
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series Journal of Chemistry
spelling doaj-art-2430c1408f9d48179a43286b82b3a3072025-02-03T06:04:48ZengWileyJournal of Chemistry2090-90712022-01-01202210.1155/2022/5884309Chrysophanol from the Roots of Kniphofia Insignis and Evaluation of Its Antibacterial ActivitiesAsnakew Amare Tadesse0Beshir Legas Muhammed1Moges Abebe Zeleke2Department of ChemistryDepartment of ChemistryDepartment of ChemistrySequential extraction of the roots of Kniphofia insignis using cold maceration techniques and column chromatographic separation leads to the isolation of one monomeric anthraquinone, chrysophanol (1). The structure of the compound was established using spectroscopic analyses including NMR (1H and 13C-NMR, infrared) and comparison with reported literature. The in vitro antibacterial activities of the crude extracts and the isolated compounds were evaluated against four bacterial strains (S. aureus ATCC 25923, B. subtilis ATCC 6633, E. coli ATCC 35218, and P. aeruginosa ATCC 27853). Among them, the crude extract, acetone extract, has shown substantial antibacterial activity with the highest activity against E. coli (22.3 mm). However, compound 1 has a better zone of inhibition with 19.3 mm against P. aeruginosa.http://dx.doi.org/10.1155/2022/5884309
spellingShingle Asnakew Amare Tadesse
Beshir Legas Muhammed
Moges Abebe Zeleke
Chrysophanol from the Roots of Kniphofia Insignis and Evaluation of Its Antibacterial Activities
Journal of Chemistry
title Chrysophanol from the Roots of Kniphofia Insignis and Evaluation of Its Antibacterial Activities
title_full Chrysophanol from the Roots of Kniphofia Insignis and Evaluation of Its Antibacterial Activities
title_fullStr Chrysophanol from the Roots of Kniphofia Insignis and Evaluation of Its Antibacterial Activities
title_full_unstemmed Chrysophanol from the Roots of Kniphofia Insignis and Evaluation of Its Antibacterial Activities
title_short Chrysophanol from the Roots of Kniphofia Insignis and Evaluation of Its Antibacterial Activities
title_sort chrysophanol from the roots of kniphofia insignis and evaluation of its antibacterial activities
url http://dx.doi.org/10.1155/2022/5884309
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