Angiogenic and Immunomodulatory effects of embryonic stem cell derived mesenchymal stem cells in a murine model of ischemic hindlimb

Angiogenic and Immunomodulatory effects of embryonic stem cell derived mesenchymal stem cells in a murine model of ischemic hindlimb

Abstract In critical limb-threatening ischemia (CLTI), failed revascularization and pharmacotherapy substantially increase amputation and mortality risks. Mesenchymal stem cells (MSCs) are a promising therapeutic option for CLTI. This study evaluated the therapeutic effects of embryonic stem cell-de...

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Bibliographic Details
Main Authors: Do Jung Kim, Young-Nam Youn, Ji Min Kim, Sang-Hyun Lim
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Embryonic stem cell-derived mesenchymal stem cell
Neovascularization
Immune modulation
Peripheral arterial disease
Limb-threatening ischemia
Online Access:https://doi.org/10.1038/s41598-025-08283-w
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