Longitudinal excitation-inhibition balance altered by sex and APOE-ε4

Abstract Neuronal hyperexcitation affects memory and neural processing across the Alzheimer’s disease (AD) cognitive continuum. Levetiracetam, an antiepileptic, shows promise in improving cognitive impairment by restoring the neural excitation/inhibition balance in AD patients. We previously identif...

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Bibliographic Details
Main Authors: Andrew P. Burns, Igor Fortel, Liang Zhan, Orly Lazarov, R. Scott Mackin, Alexander P. Demos, Barbara Bendlin, Alex Leow
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07876-5
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