Longitudinal excitation-inhibition balance altered by sex and APOE-ε4
Abstract Neuronal hyperexcitation affects memory and neural processing across the Alzheimer’s disease (AD) cognitive continuum. Levetiracetam, an antiepileptic, shows promise in improving cognitive impairment by restoring the neural excitation/inhibition balance in AD patients. We previously identif...
Saved in:
| Main Authors: | Andrew P. Burns, Igor Fortel, Liang Zhan, Orly Lazarov, R. Scott Mackin, Alexander P. Demos, Barbara Bendlin, Alex Leow |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-03-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-07876-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Sex variation in the relationship between APOE ε4, cognitive decline, and dementia
by: Eleanor M. Kerr, et al.
Published: (2025-04-01) -
APOE ε4 and exercise interact in a sex‐specific manner to modulate dementia risk factors
by: Kate E. Foley, et al.
Published: (2022-01-01) -
Variable and interactive effects of Sex, APOE ε4 and TREM2 on the deposition of tau in entorhinal and neocortical regions
by: Joseph Giorgio, et al.
Published: (2025-07-01) -
Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats
by: Bonnie H. Lee, et al.
Published: (2025-02-01) -
Inferring excitation-inhibition dynamics using a maximum entropy
model unifying brain structure and function
by: Igor Fortel, et al.
Published: (2022-06-01)