Optimization of Conditions for Expression of Dengue Serotype 2 EDIII Protein in <i>Escherichia coli</i> and Immune Responses of Adjuvant-Free EDIII Ferritin Nanoparticles Against Dengue Virus in BALB/c Mice

Optimization of Conditions for Expression of Dengue Serotype 2 EDIII Protein in <i>Escherichia coli</i> and Immune Responses of Adjuvant-Free EDIII Ferritin Nanoparticles Against Dengue Virus in BALB/c Mice

Self-assembling ferritin nanoparticle technology is a widely used vaccine development platform for enhancing the efficacy of subunit vaccines by displaying multiple antigens on nanocages. The dengue virus (DENV) envelope domain III (EDIII) protein, the most promising antigen for DENV, has been appli...

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Bibliographic Details
Main Authors: M.S.B.W.T.M. Nipuna Sudaraka Tennakoon, Kyoung-Ho Lee, Hye-Mi Lee, Jae-Yeon Park, Hyun-Jin Shin
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Viruses
Subjects:
dengue
ferritin nanoparticles
EDIII
<i>Escherichia coli</i> expression
protein aggregates
immune responses
Online Access:https://www.mdpi.com/1999-4915/17/1/129
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