The Cytoplasm-to-Vacuole Targeting Pathway: A Historical Perspective
From today's perspective, it is obvious that macroautophagy (hereafter autophagy) is an important pathway that is connected to a range of developmental and physiological processes. This viewpoint, however, is relatively recent, coinciding with the molecular identification of autophagy-related (...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/142634 |
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| _version_ | 1832558781768138752 |
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| author | Midori Umekawa Daniel J. Klionsky |
| author_facet | Midori Umekawa Daniel J. Klionsky |
| author_sort | Midori Umekawa |
| collection | DOAJ |
| description | From today's perspective, it is obvious that macroautophagy (hereafter autophagy) is an important pathway that is connected to a range of developmental and physiological processes. This viewpoint, however, is relatively recent, coinciding with the molecular identification of autophagy-related (Atg) components that function as the protein machinery that drives the dynamic membrane events of autophagy. It may be difficult, especially for scientists new to this area of research, to appreciate that the field of autophagy long existed as a “backwater” topic that attracted little interest or attention. Paralleling the development of the autophagy field was the identification and analysis of the cytoplasm-to-vacuole targeting (Cvt) pathway, the only characterized biosynthetic route that utilizes the Atg proteins. Here, we relate some of the initial history, including some never-before-revealed facts, of the analysis of the Cvt pathway and the convergence of those studies with autophagy. |
| format | Article |
| id | doaj-art-2422527be68347a0a18c1d2e8884082c |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-2422527be68347a0a18c1d2e8884082c2025-02-03T01:31:34ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/142634142634The Cytoplasm-to-Vacuole Targeting Pathway: A Historical PerspectiveMidori Umekawa0Daniel J. Klionsky1Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USALife Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USAFrom today's perspective, it is obvious that macroautophagy (hereafter autophagy) is an important pathway that is connected to a range of developmental and physiological processes. This viewpoint, however, is relatively recent, coinciding with the molecular identification of autophagy-related (Atg) components that function as the protein machinery that drives the dynamic membrane events of autophagy. It may be difficult, especially for scientists new to this area of research, to appreciate that the field of autophagy long existed as a “backwater” topic that attracted little interest or attention. Paralleling the development of the autophagy field was the identification and analysis of the cytoplasm-to-vacuole targeting (Cvt) pathway, the only characterized biosynthetic route that utilizes the Atg proteins. Here, we relate some of the initial history, including some never-before-revealed facts, of the analysis of the Cvt pathway and the convergence of those studies with autophagy.http://dx.doi.org/10.1155/2012/142634 |
| spellingShingle | Midori Umekawa Daniel J. Klionsky The Cytoplasm-to-Vacuole Targeting Pathway: A Historical Perspective International Journal of Cell Biology |
| title | The Cytoplasm-to-Vacuole Targeting Pathway: A Historical Perspective |
| title_full | The Cytoplasm-to-Vacuole Targeting Pathway: A Historical Perspective |
| title_fullStr | The Cytoplasm-to-Vacuole Targeting Pathway: A Historical Perspective |
| title_full_unstemmed | The Cytoplasm-to-Vacuole Targeting Pathway: A Historical Perspective |
| title_short | The Cytoplasm-to-Vacuole Targeting Pathway: A Historical Perspective |
| title_sort | cytoplasm to vacuole targeting pathway a historical perspective |
| url | http://dx.doi.org/10.1155/2012/142634 |
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