Microglial pyroptosis as a therapeutic target after traumatic spinal cord injury: current progress and future directions

Microglial pyroptosis as a therapeutic target after traumatic spinal cord injury: current progress and future directions

Traumatic spinal cord injury (TSCI) is a devastating neurological condition with limited therapeutic options and a high likelihood of permanent disability. Among the multifaceted secondary injury mechanisms triggered by TSCI, pyroptosis—an inflammatory form of programmed cell death—has emerged as a...

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Bibliographic Details
Main Authors: Lei Shi, Qiheng Qian, Jiding Xie, Taoshuo Yang, Xinyu Zhao, Xiangqi Meng, Jingang Dai, Qiguan Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
traumatic spinal cord injury
pyroptosis
microglia
inflammation
NLRP3
GSDMD
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1649790/full
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