Gata3 drives miR-21-5p transcription to mitigate hyperoxia-induced lung injury, independent of CpG Island methylation

Gata3 drives miR-21-5p transcription to mitigate hyperoxia-induced lung injury, independent of CpG Island methylation

Abstract microRNA-21-5p (miR-21-5p) plays a key anti-apoptotic role in hyperoxia-induced lung injury (HALI), but its regulatory mechanisms are not well understood. This study identified Gata3 as a novel upstream transcription factor that enhanced miR-21-5p expression. Bioinformatic analyses and GEO...

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Bibliographic Details
Main Authors: Yingcong Ren, Song Qin, Ping Yuan, Qianxia Huang, Ma Huang, Yuanzhi Shi, Miao Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Hyperoxia-induced lung injury
Gata3
miR-21-5p
Alveolar epithelial cells
Apoptosis
Online Access:https://doi.org/10.1038/s41598-025-09039-2
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