Sirtuin 2 inhibitor AGK2 exerts antiviral effects by inducing epigenetic suppression of hepatitis B virus covalently closed circular DNA through recruitment of repressive histone lysine methyltransferases and reduction of cccDNA

Sirtuin 2 inhibitor AGK2 exerts antiviral effects by inducing epigenetic suppression of hepatitis B virus covalently closed circular DNA through recruitment of repressive histone lysine methyltransferases and reduction of cccDNA

Chronic hepatitis B virus (HBV) infection continues to be a global health concern because current treatments such as interferon-α and nucleos(t)ide analogs cannot fully eliminate the virus due to persistence of covalently closed circular DNA (cccDNA) and integrated HBV DNA. Earlier research suggests...

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Bibliographic Details
Main Authors: Jumi Kim, Jiseon Ha, Chanho Song, Muhammad Azhar Sajjad, Fadia Kalsoom, Hyeonjoong Kwon, Jaewoo Park, Sun Park, Kyongmin Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
hepatitis B virus
covalently closed circular DNA
SIRT2 inhibitor AGK2
repressive histone lysine methyltransferases
epigenetic suppression
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1537929/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1537929/full

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