Evaluating the effect of virgin coconut oil pulling on viral load, bacterial load and inflammatory mediator levels in chronic periodontitis – A clinical study
Background and objective: Periodontitis and dental caries are among the most prevalent oral diseases, with chronic periodontitis being a multifactorial, infectious condition that leads to inflammation in the supporting structures of the teeth, progressive attachment loss, and bone resorption. Chroni...
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Elsevier
2025-01-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426825000065 |
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| author | Monika M Rudhra K Vennila K Elanchezhiyan Sri Harini P S. Shakeron |
| author_facet | Monika M Rudhra K Vennila K Elanchezhiyan Sri Harini P S. Shakeron |
| author_sort | Monika M |
| collection | DOAJ |
| description | Background and objective: Periodontitis and dental caries are among the most prevalent oral diseases, with chronic periodontitis being a multifactorial, infectious condition that leads to inflammation in the supporting structures of the teeth, progressive attachment loss, and bone resorption. Chronic periodontitis is driven by a consortium of pathogenic microorganisms. This study aimed to evaluate the efficacy of virgin coconut oil (VCO) pulling in reducing the microbial load and inflammatory mediators responsible for chronic periodontitis, in comparison to chlorhexidine (CHX) mouthwash and distilled water. Methods: Thirty patients diagnosed with chronic periodontitis were randomly allocated into three groups. Group A served as the control and used distilled water for oral rinsing, Group B used chlorhexidine mouthwash, and Group C performed oil pulling with virgin coconut oil. Pre-operative subgingival plaque samples were collected from all participants, followed by complete scaling and root planing. Post-operative samples were collected after four weeks. Both pre- and post-treatment samples were subjected to real-time PCR (rtPCR) and enzyme-linked immunosorbent assay (ELISA) to quantify viral and bacterial loads, as well as levels of key inflammatory mediators. Results: A significant reduction in viral load, bacterial load, and inflammatory mediators was observed in both the VCO and CHX groups compared to the distilled water group. The reductions in the VCO and CHX groups were statistically significant, with comparable efficacy between the two interventions. Conclusion: Virgin coconut oil pulling demonstrated a significant reduction in microbial and inflammatory markers in patients with chronic periodontitis, showing similar efficacy to chlorhexidine mouthwash. Given its comparable therapeutic effects and reduced side effect profile, VCO presents a viable alternative to chlorhexidine for managing chronic periodontitis. |
| format | Article |
| id | doaj-art-241e0ee5eec84dda916719cabbf15d0f |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-241e0ee5eec84dda916719cabbf15d0f2025-02-09T05:00:16ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682025-01-01151153158Evaluating the effect of virgin coconut oil pulling on viral load, bacterial load and inflammatory mediator levels in chronic periodontitis – A clinical studyMonika M0Rudhra K1Vennila K2 Elanchezhiyan3Sri Harini P4S. Shakeron5Department of Periodontics, Vivekanandha Dental College for Women, IndiaDepartment of Periodontics, Sree Balaji Dental College and Hospitals, Chennai, IndiaDepartment of Periodontics, Vivekanandha Dental College for Women, India; Corresponding author.Department of Periodontics, JKKN Dental College and Hospital, IndiaDepartment of Periodontics, Vivekanandha Dental College for Women, IndiaDepartment of Periodontics, Vivekanandha Dental College for Women, IndiaBackground and objective: Periodontitis and dental caries are among the most prevalent oral diseases, with chronic periodontitis being a multifactorial, infectious condition that leads to inflammation in the supporting structures of the teeth, progressive attachment loss, and bone resorption. Chronic periodontitis is driven by a consortium of pathogenic microorganisms. This study aimed to evaluate the efficacy of virgin coconut oil (VCO) pulling in reducing the microbial load and inflammatory mediators responsible for chronic periodontitis, in comparison to chlorhexidine (CHX) mouthwash and distilled water. Methods: Thirty patients diagnosed with chronic periodontitis were randomly allocated into three groups. Group A served as the control and used distilled water for oral rinsing, Group B used chlorhexidine mouthwash, and Group C performed oil pulling with virgin coconut oil. Pre-operative subgingival plaque samples were collected from all participants, followed by complete scaling and root planing. Post-operative samples were collected after four weeks. Both pre- and post-treatment samples were subjected to real-time PCR (rtPCR) and enzyme-linked immunosorbent assay (ELISA) to quantify viral and bacterial loads, as well as levels of key inflammatory mediators. Results: A significant reduction in viral load, bacterial load, and inflammatory mediators was observed in both the VCO and CHX groups compared to the distilled water group. The reductions in the VCO and CHX groups were statistically significant, with comparable efficacy between the two interventions. Conclusion: Virgin coconut oil pulling demonstrated a significant reduction in microbial and inflammatory markers in patients with chronic periodontitis, showing similar efficacy to chlorhexidine mouthwash. Given its comparable therapeutic effects and reduced side effect profile, VCO presents a viable alternative to chlorhexidine for managing chronic periodontitis.http://www.sciencedirect.com/science/article/pii/S2212426825000065Chronic periodontitisVirgin coconut oilAnti-microbial propertyAnti-inflammatory property |
| spellingShingle | Monika M Rudhra K Vennila K Elanchezhiyan Sri Harini P S. Shakeron Evaluating the effect of virgin coconut oil pulling on viral load, bacterial load and inflammatory mediator levels in chronic periodontitis – A clinical study Journal of Oral Biology and Craniofacial Research Chronic periodontitis Virgin coconut oil Anti-microbial property Anti-inflammatory property |
| title | Evaluating the effect of virgin coconut oil pulling on viral load, bacterial load and inflammatory mediator levels in chronic periodontitis – A clinical study |
| title_full | Evaluating the effect of virgin coconut oil pulling on viral load, bacterial load and inflammatory mediator levels in chronic periodontitis – A clinical study |
| title_fullStr | Evaluating the effect of virgin coconut oil pulling on viral load, bacterial load and inflammatory mediator levels in chronic periodontitis – A clinical study |
| title_full_unstemmed | Evaluating the effect of virgin coconut oil pulling on viral load, bacterial load and inflammatory mediator levels in chronic periodontitis – A clinical study |
| title_short | Evaluating the effect of virgin coconut oil pulling on viral load, bacterial load and inflammatory mediator levels in chronic periodontitis – A clinical study |
| title_sort | evaluating the effect of virgin coconut oil pulling on viral load bacterial load and inflammatory mediator levels in chronic periodontitis a clinical study |
| topic | Chronic periodontitis Virgin coconut oil Anti-microbial property Anti-inflammatory property |
| url | http://www.sciencedirect.com/science/article/pii/S2212426825000065 |
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