PAIN AND INFLAMMATION. PART 1. PATHOGENETIC ASPECTS
The relief of suffering, which is associated with a rapid and complete elimination of painful sensations, is the most important challenge facing physicians of many specialties. It is obvious that it can be solved only when you understand clearly the processes governing the development and chronizati...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2017-01-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2325 |
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| author | A. E. Karateev D. E. Karateev O. S. Davydov |
| author_facet | A. E. Karateev D. E. Karateev O. S. Davydov |
| author_sort | A. E. Karateev |
| collection | DOAJ |
| description | The relief of suffering, which is associated with a rapid and complete elimination of painful sensations, is the most important challenge facing physicians of many specialties. It is obvious that it can be solved only when you understand clearly the processes governing the development and chronization of pain. Inflammation, a universal adaptive mechanism that always accompanies damage to living tissues, plays a key role. Part 1 of this review considers the main stages of development of an inflammatory response, beginning with primary damage accompanied by the release of molecules acting as an alarm and ending with the deployment of a complete picture of the inflammatory response with the involvement of many cell elements and the overexpression of cytokines and proinflammatory mediators. The biological basis of the peripheral and central nociceptive sensitization phenomenon that is rigidly associated with inflammation is presented. Particular emphasis is placed on the possible natural completion of the inflammatory response, on the adaptive mechanisms regulating this process and on the reasons that prevent this and determines inflammation chronization. |
| format | Article |
| id | doaj-art-241bb00324fe49e49f93a74cbfe49102 |
| institution | DOAJ |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2017-01-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-241bb00324fe49e49f93a74cbfe491022025-08-20T02:55:19ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922017-01-0154669370410.14412/1995-4484-2016-693-7042187PAIN AND INFLAMMATION. PART 1. PATHOGENETIC ASPECTSA. E. Karateev0D. E. Karateev1O. S. Davydov2V. A. Nasonova Research Institute of RheumatologyV. A. Nasonova Research Institute of RheumatologyZ.P. Solovyev Research and Practical Center of Psychoneurology, Moscow Healthcare DepartmentThe relief of suffering, which is associated with a rapid and complete elimination of painful sensations, is the most important challenge facing physicians of many specialties. It is obvious that it can be solved only when you understand clearly the processes governing the development and chronization of pain. Inflammation, a universal adaptive mechanism that always accompanies damage to living tissues, plays a key role. Part 1 of this review considers the main stages of development of an inflammatory response, beginning with primary damage accompanied by the release of molecules acting as an alarm and ending with the deployment of a complete picture of the inflammatory response with the involvement of many cell elements and the overexpression of cytokines and proinflammatory mediators. The biological basis of the peripheral and central nociceptive sensitization phenomenon that is rigidly associated with inflammation is presented. Particular emphasis is placed on the possible natural completion of the inflammatory response, on the adaptive mechanisms regulating this process and on the reasons that prevent this and determines inflammation chronization.https://rsp.mediar-press.net/rsp/article/view/2325paininflammationmacrophagescytokinesmediators of inflammation and painnociceptorsperipheral and central sensitization |
| spellingShingle | A. E. Karateev D. E. Karateev O. S. Davydov PAIN AND INFLAMMATION. PART 1. PATHOGENETIC ASPECTS Научно-практическая ревматология pain inflammation macrophages cytokines mediators of inflammation and pain nociceptors peripheral and central sensitization |
| title | PAIN AND INFLAMMATION. PART 1. PATHOGENETIC ASPECTS |
| title_full | PAIN AND INFLAMMATION. PART 1. PATHOGENETIC ASPECTS |
| title_fullStr | PAIN AND INFLAMMATION. PART 1. PATHOGENETIC ASPECTS |
| title_full_unstemmed | PAIN AND INFLAMMATION. PART 1. PATHOGENETIC ASPECTS |
| title_short | PAIN AND INFLAMMATION. PART 1. PATHOGENETIC ASPECTS |
| title_sort | pain and inflammation part 1 pathogenetic aspects |
| topic | pain inflammation macrophages cytokines mediators of inflammation and pain nociceptors peripheral and central sensitization |
| url | https://rsp.mediar-press.net/rsp/article/view/2325 |
| work_keys_str_mv | AT aekarateev painandinflammationpart1pathogeneticaspects AT dekarateev painandinflammationpart1pathogeneticaspects AT osdavydov painandinflammationpart1pathogeneticaspects |