Fragmentation patterns and personalized sequencing of cell‐free DNA in urine and plasma of glioma patients

Fragmentation patterns and personalized sequencing of cell‐free DNA in urine and plasma of glioma patients

Abstract Glioma‐derived cell‐free DNA (cfDNA) is challenging to detect using liquid biopsy because quantities in body fluids are low. We determined the glioma‐derived DNA fraction in cerebrospinal fluid (CSF), plasma, and urine samples from patients using sequencing of personalized capture panels gu...

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Bibliographic Details
Main Authors: Florent Mouliere, Christopher G Smith, Katrin Heider, Jing Su, Ymke van der Pol, Mareike Thompson, James Morris, Jonathan C M Wan, Dineika Chandrananda, James Hadfield, Marta Grzelak, Irena Hudecova, Dominique‐Laurent Couturier, Wendy Cooper, Hui Zhao, Davina Gale, Matthew Eldridge, Colin Watts, Kevin Brindle, Nitzan Rosenfeld, Richard Mair
Format: Article
Language:English
Published: Springer Nature 2021-07-01
Series:EMBO Molecular Medicine
Subjects:
cell‐free DNA
circulating tumor DNA
fragmentomics
gliomas
liquid biopsy
Online Access:https://doi.org/10.15252/emmm.202012881
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