Investigation of chitin grafting: thermal, antioxidant and antitumor properties
Abstract In this study, firstly chitin was reacted with chloracetyl chloride to synthesize the macroinitiator chitinchloroacetate (Ch.ClAc). Then, graft copolymers of methacrylamide (MAM), diacetone acrylamide (DAAM), N-(4-nitrophenyl)acrylamide (NPA), and 2-hydroxyethyl methacrylate (HEMA) monomers...
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Discover Nano |
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| Online Access: | https://doi.org/10.1186/s11671-025-04185-y |
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| author | Nevin Çankaya Mehmet Mürşit Temüz Burak Can |
| author_facet | Nevin Çankaya Mehmet Mürşit Temüz Burak Can |
| author_sort | Nevin Çankaya |
| collection | DOAJ |
| description | Abstract In this study, firstly chitin was reacted with chloracetyl chloride to synthesize the macroinitiator chitinchloroacetate (Ch.ClAc). Then, graft copolymers of methacrylamide (MAM), diacetone acrylamide (DAAM), N-(4-nitrophenyl)acrylamide (NPA), and 2-hydroxyethyl methacrylate (HEMA) monomers were synthesized by atom transfer radical polymerization (ATRP). All of the polymers were characterized by FTIR spectra and elemental analysis. According to the elemental analysis results, the mole percent (y) of the macro initiator was found to be 17.39%. The thermal stability of all the polymers (chitin, Ch.ClAc and its graft copolymers) was determined by thermogravimetric analysis (TGA) method and the highest thermal stability was observed in the ungrafted raw chitin. DPPH• scavenging activity and antitumor activity of all polymers were then investigated. Ch.ClAc was found to be the polymer that inhibited the proliferation of tumor cells more than chitin and graft copolymers. It was observed that the antitumor (L1210 cell lines) effect increased with increasing time and concentration in all polymers. |
| format | Article |
| id | doaj-art-2411fe150ff149489137dbb15c92a373 |
| institution | Kabale University |
| issn | 2731-9229 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Nano |
| spelling | doaj-art-2411fe150ff149489137dbb15c92a3732025-01-19T12:36:18ZengSpringerDiscover Nano2731-92292025-01-0120111010.1186/s11671-025-04185-yInvestigation of chitin grafting: thermal, antioxidant and antitumor propertiesNevin Çankaya0Mehmet Mürşit Temüz1Burak Can2Vocational School of Health Services-Oral and Dental Health Department, Usak UniversityFaculty of Science, Department of Chemistry, Firat UniversityInstitute of Science, Department of Chemistry, Firat UniversityAbstract In this study, firstly chitin was reacted with chloracetyl chloride to synthesize the macroinitiator chitinchloroacetate (Ch.ClAc). Then, graft copolymers of methacrylamide (MAM), diacetone acrylamide (DAAM), N-(4-nitrophenyl)acrylamide (NPA), and 2-hydroxyethyl methacrylate (HEMA) monomers were synthesized by atom transfer radical polymerization (ATRP). All of the polymers were characterized by FTIR spectra and elemental analysis. According to the elemental analysis results, the mole percent (y) of the macro initiator was found to be 17.39%. The thermal stability of all the polymers (chitin, Ch.ClAc and its graft copolymers) was determined by thermogravimetric analysis (TGA) method and the highest thermal stability was observed in the ungrafted raw chitin. DPPH• scavenging activity and antitumor activity of all polymers were then investigated. Ch.ClAc was found to be the polymer that inhibited the proliferation of tumor cells more than chitin and graft copolymers. It was observed that the antitumor (L1210 cell lines) effect increased with increasing time and concentration in all polymers.https://doi.org/10.1186/s11671-025-04185-yChitinGraft copolymerThermal stabilityAntioxidantAntitumor |
| spellingShingle | Nevin Çankaya Mehmet Mürşit Temüz Burak Can Investigation of chitin grafting: thermal, antioxidant and antitumor properties Discover Nano Chitin Graft copolymer Thermal stability Antioxidant Antitumor |
| title | Investigation of chitin grafting: thermal, antioxidant and antitumor properties |
| title_full | Investigation of chitin grafting: thermal, antioxidant and antitumor properties |
| title_fullStr | Investigation of chitin grafting: thermal, antioxidant and antitumor properties |
| title_full_unstemmed | Investigation of chitin grafting: thermal, antioxidant and antitumor properties |
| title_short | Investigation of chitin grafting: thermal, antioxidant and antitumor properties |
| title_sort | investigation of chitin grafting thermal antioxidant and antitumor properties |
| topic | Chitin Graft copolymer Thermal stability Antioxidant Antitumor |
| url | https://doi.org/10.1186/s11671-025-04185-y |
| work_keys_str_mv | AT nevincankaya investigationofchitingraftingthermalantioxidantandantitumorproperties AT mehmetmursittemuz investigationofchitingraftingthermalantioxidantandantitumorproperties AT burakcan investigationofchitingraftingthermalantioxidantandantitumorproperties |