Eltrombopag Improves Refractory Thrombocytopenia in a Patient with Systemic Lupus Erythematosus
A 42-year-old woman with systemic lupus erythematosus (SLE) was admitted to our hospital for evaluation of severe thrombocytopenia. She was treated with steroids, intravenous cyclophosphamide, intravenous immunoglobulin, and plasma exchange, but her thrombocytopenia did not improve. Renal biopsy sho...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2018/6305356 |
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| author | Natsuki Shima Keiichi Sumida Masahiro Kawada Akinari Sekine Masayuki Yamanouchi Rikako Hiramatsu Noriko Hayami Eiko Hasegawa Tatsuya Suwabe Junichi Hoshino Naoki Sawa Kenmei Takaichi Kenichi Ohashi Takeshi Fujii Yoshifumi Ubara |
| author_facet | Natsuki Shima Keiichi Sumida Masahiro Kawada Akinari Sekine Masayuki Yamanouchi Rikako Hiramatsu Noriko Hayami Eiko Hasegawa Tatsuya Suwabe Junichi Hoshino Naoki Sawa Kenmei Takaichi Kenichi Ohashi Takeshi Fujii Yoshifumi Ubara |
| author_sort | Natsuki Shima |
| collection | DOAJ |
| description | A 42-year-old woman with systemic lupus erythematosus (SLE) was admitted to our hospital for evaluation of severe thrombocytopenia. She was treated with steroids, intravenous cyclophosphamide, intravenous immunoglobulin, and plasma exchange, but her thrombocytopenia did not improve. Renal biopsy showed class IV-S(C) + V lupus nephritis, according to the classification of the International Society of Nephrology/Renal Pathology Society. The PA-IgG and serum thrombopoietin (TPO) levels were elevated. Her thrombocytopenia responded to off-label administration of eltrombopag, which was discontinued after 42 months. At 18 months after stopping eltrombopag, the platelet count was 19.3 × 104/μL. Eltrombopag may be a therapeutic option for SLE patients with severe thrombocytopenia refractory to conventional therapy. |
| format | Article |
| id | doaj-art-23fa288715fe432bb04fa1f40edde42e |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-23fa288715fe432bb04fa1f40edde42e2025-02-03T06:13:25ZengWileyCase Reports in Rheumatology2090-68892090-68972018-01-01201810.1155/2018/63053566305356Eltrombopag Improves Refractory Thrombocytopenia in a Patient with Systemic Lupus ErythematosusNatsuki Shima0Keiichi Sumida1Masahiro Kawada2Akinari Sekine3Masayuki Yamanouchi4Rikako Hiramatsu5Noriko Hayami6Eiko Hasegawa7Tatsuya Suwabe8Junichi Hoshino9Naoki Sawa10Kenmei Takaichi11Kenichi Ohashi12Takeshi Fujii13Yoshifumi Ubara14Nephrology Center, Toranomon Hospital, Kawasaki, Kanagawa, JapanNephrology Center, Toranomon Hospital, Kawasaki, Kanagawa, JapanNephrology Center, Toranomon Hospital, Kawasaki, Kanagawa, JapanNephrology Center, Toranomon Hospital, Kawasaki, Kanagawa, JapanNephrology Center, Toranomon Hospital, Kawasaki, Kanagawa, JapanNephrology Center, Toranomon Hospital, Kawasaki, Kanagawa, JapanNephrology Center, Toranomon Hospital, Kawasaki, Kanagawa, JapanNephrology Center, Toranomon Hospital, Kawasaki, Kanagawa, JapanNephrology Center, Toranomon Hospital, Kawasaki, Kanagawa, JapanNephrology Center, Toranomon Hospital, Kawasaki, Kanagawa, JapanNephrology Center, Toranomon Hospital, Kawasaki, Kanagawa, JapanNephrology Center, Toranomon Hospital, Kawasaki, Kanagawa, JapanDepartment of Pathology, Toranomon Hospital, Tokyo, JapanDepartment of Pathology, Toranomon Hospital, Tokyo, JapanNephrology Center, Toranomon Hospital, Kawasaki, Kanagawa, JapanA 42-year-old woman with systemic lupus erythematosus (SLE) was admitted to our hospital for evaluation of severe thrombocytopenia. She was treated with steroids, intravenous cyclophosphamide, intravenous immunoglobulin, and plasma exchange, but her thrombocytopenia did not improve. Renal biopsy showed class IV-S(C) + V lupus nephritis, according to the classification of the International Society of Nephrology/Renal Pathology Society. The PA-IgG and serum thrombopoietin (TPO) levels were elevated. Her thrombocytopenia responded to off-label administration of eltrombopag, which was discontinued after 42 months. At 18 months after stopping eltrombopag, the platelet count was 19.3 × 104/μL. Eltrombopag may be a therapeutic option for SLE patients with severe thrombocytopenia refractory to conventional therapy.http://dx.doi.org/10.1155/2018/6305356 |
| spellingShingle | Natsuki Shima Keiichi Sumida Masahiro Kawada Akinari Sekine Masayuki Yamanouchi Rikako Hiramatsu Noriko Hayami Eiko Hasegawa Tatsuya Suwabe Junichi Hoshino Naoki Sawa Kenmei Takaichi Kenichi Ohashi Takeshi Fujii Yoshifumi Ubara Eltrombopag Improves Refractory Thrombocytopenia in a Patient with Systemic Lupus Erythematosus Case Reports in Rheumatology |
| title | Eltrombopag Improves Refractory Thrombocytopenia in a Patient with Systemic Lupus Erythematosus |
| title_full | Eltrombopag Improves Refractory Thrombocytopenia in a Patient with Systemic Lupus Erythematosus |
| title_fullStr | Eltrombopag Improves Refractory Thrombocytopenia in a Patient with Systemic Lupus Erythematosus |
| title_full_unstemmed | Eltrombopag Improves Refractory Thrombocytopenia in a Patient with Systemic Lupus Erythematosus |
| title_short | Eltrombopag Improves Refractory Thrombocytopenia in a Patient with Systemic Lupus Erythematosus |
| title_sort | eltrombopag improves refractory thrombocytopenia in a patient with systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2018/6305356 |
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