Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A Review
Yisong Ren, Gang Chen, Ying Hong, Qianying Wang, Bo Lan, Zhaozhao Huang Department of Critical Care Medicine, Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu, Sichuan Province, 611731, People’s Republic of ChinaCorrespondence: Zhaozhao Huang, Department of Critical Care Medic...
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Dove Medical Press
2025-01-01
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| author | Ren Y Chen G Hong Y Wang Q Lan B Huang Z |
| author_facet | Ren Y Chen G Hong Y Wang Q Lan B Huang Z |
| author_sort | Ren Y |
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| description | Yisong Ren, Gang Chen, Ying Hong, Qianying Wang, Bo Lan, Zhaozhao Huang Department of Critical Care Medicine, Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu, Sichuan Province, 611731, People’s Republic of ChinaCorrespondence: Zhaozhao Huang, Department of Critical Care Medicine, Chengdu Pidu District Hospital of Traditional Chinese Medicine, No. 169, Zhongxin Avenue, Pidu District, Chengdu, Sichuan Province, 611731, People’s Republic of China, Email tcmhzz@126.comAbstract: Cerebral ischemia-reperfusion injury (CIRI) is clinically characterized by high rates of morbidity, disability, mortality, and recurrence as well as high economic burden. The clinical manifestations of CIRI are often accompanied by gastrointestinal symptoms such as intestinal bacterial dysbiosis and gastrointestinal bleeding. Gut microbiota plays an important role in the pathogenesis of CIRI, and its potential biological effects have received extensive attention. The gut microbiota not only affects intestinal barrier function but also regulates gastrointestinal immunity and host homeostasis. Traditional Chinese medicine (TCM), a multi-component and multi-targeted drug, has shown remarkable effects and few adverse reactions in the prevention and treatment of CIRI. Notably, the effect of TCM on CIRI by regulating gut microbiota and maintaining gastrointestinal homeostasis has gradually become a hot topic. This review summarizes the functional role of the gut microbiota in the development and progression of CIRI and the therapeutic effects of TCM on CIRI by improving gut microbiota dysbiosis, affecting gut microbiota metabolism, and maintaining host immunity. The active ingredients of TCM used for the treatment of CIRI in relevant studies were saponins, triterpenoids, phenolics, and alkaloids. In addition, the clinical effects of TCM used to treat CIRI were briefly discussed. This review established the clinical significance and development prospects of TCM-based CIRI treatments and provided the necessary theoretical support for the further development of TCM resources for the treatment of CIRI.Keywords: cerebral ischemia-reperfusion injury, ischemic stroke, gut-brain axis, gut microbiota, traditional Chinese medicine |
| format | Article |
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| institution | Kabale University |
| issn | 1177-8881 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
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| series | Drug Design, Development and Therapy |
| spelling | doaj-art-23f66232b7c943dabad64258277588ed2025-01-12T16:52:42ZengDove Medical PressDrug Design, Development and Therapy1177-88812025-01-01Volume 1918520099171Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A ReviewRen YChen GHong YWang QLan BHuang ZYisong Ren, Gang Chen, Ying Hong, Qianying Wang, Bo Lan, Zhaozhao Huang Department of Critical Care Medicine, Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu, Sichuan Province, 611731, People’s Republic of ChinaCorrespondence: Zhaozhao Huang, Department of Critical Care Medicine, Chengdu Pidu District Hospital of Traditional Chinese Medicine, No. 169, Zhongxin Avenue, Pidu District, Chengdu, Sichuan Province, 611731, People’s Republic of China, Email tcmhzz@126.comAbstract: Cerebral ischemia-reperfusion injury (CIRI) is clinically characterized by high rates of morbidity, disability, mortality, and recurrence as well as high economic burden. The clinical manifestations of CIRI are often accompanied by gastrointestinal symptoms such as intestinal bacterial dysbiosis and gastrointestinal bleeding. Gut microbiota plays an important role in the pathogenesis of CIRI, and its potential biological effects have received extensive attention. The gut microbiota not only affects intestinal barrier function but also regulates gastrointestinal immunity and host homeostasis. Traditional Chinese medicine (TCM), a multi-component and multi-targeted drug, has shown remarkable effects and few adverse reactions in the prevention and treatment of CIRI. Notably, the effect of TCM on CIRI by regulating gut microbiota and maintaining gastrointestinal homeostasis has gradually become a hot topic. This review summarizes the functional role of the gut microbiota in the development and progression of CIRI and the therapeutic effects of TCM on CIRI by improving gut microbiota dysbiosis, affecting gut microbiota metabolism, and maintaining host immunity. The active ingredients of TCM used for the treatment of CIRI in relevant studies were saponins, triterpenoids, phenolics, and alkaloids. In addition, the clinical effects of TCM used to treat CIRI were briefly discussed. This review established the clinical significance and development prospects of TCM-based CIRI treatments and provided the necessary theoretical support for the further development of TCM resources for the treatment of CIRI.Keywords: cerebral ischemia-reperfusion injury, ischemic stroke, gut-brain axis, gut microbiota, traditional Chinese medicinehttps://www.dovepress.com/novel-insight-into-the-modulatory-effect-of-traditional-chinese-medici-peer-reviewed-fulltext-article-DDDTcerebral ischemia-reperfusion injuryischemic strokegut-brain axisgut microbiotatraditional chinese medicine |
| spellingShingle | Ren Y Chen G Hong Y Wang Q Lan B Huang Z Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A Review Drug Design, Development and Therapy cerebral ischemia-reperfusion injury ischemic stroke gut-brain axis gut microbiota traditional chinese medicine |
| title | Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A Review |
| title_full | Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A Review |
| title_fullStr | Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A Review |
| title_full_unstemmed | Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A Review |
| title_short | Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A Review |
| title_sort | novel insight into the modulatory effect of traditional chinese medicine on cerebral ischemia reperfusion injury by targeting gut microbiota a review |
| topic | cerebral ischemia-reperfusion injury ischemic stroke gut-brain axis gut microbiota traditional chinese medicine |
| url | https://www.dovepress.com/novel-insight-into-the-modulatory-effect-of-traditional-chinese-medici-peer-reviewed-fulltext-article-DDDT |
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