ALDH<sup>High</sup> Breast Cancer Stem Cells Exhibit a Mesenchymal–Senescent Hybrid Phenotype, with Elevated Metabolic and Migratory Activities

ALDH<sup>High</sup> Breast Cancer Stem Cells Exhibit a Mesenchymal–Senescent Hybrid Phenotype, with Elevated Metabolic and Migratory Activities

Cancer stem cells (CSCs) account for 0.01 to 2% of the total tumor mass; however, they play a key role in tumor progression, metastasis and resistance to current cancer therapies. The generation and maintenance of CSCs are usually linked to the epithelial–mesenchymal transition (EMT), a dynamic proc...

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Bibliographic Details
Main Authors: Luis Larrea Murillo, Conor J. Sugden, Bela Ozsvari, Zahra Moftakhar, Ghada S. Hassan, Federica Sotgia, Michael P. Lisanti
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
cancer stem cells
EMT
aldehyde dehydrogenase
cell senescence
metabolic reprogramming
mtDNA
Online Access:https://www.mdpi.com/2073-4409/13/24/2059
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