Exercise capacity, dyspnea, and quality of life 6 months after exercise-based rehabilitation in patients with persistent dyspnea following pulmonary embolism
Background: Exercise is safe and effective in the short-term following pulmonary embolism. To date, little is known about the long-term effects. Objectives: The aim of the study was to investigate whether the effects of exercise-based rehabilitation are maintained 6 months after completion in patien...
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Elsevier
2025-02-01
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| Series: | Research and Practice in Thrombosis and Haemostasis |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2475037925000603 |
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| author | Stacey Haukeland-Parker Øyvind Jervan Waleed Ghanima Martijn A. Spruit René Holst Jostein Gleditsch Mazdak Tavoly Knut Stavem Kjetil Steine Dan Atar Anders Erik Astrup Dahm Frederikus A. Klok Hege Hølmo Johannessen |
| author_facet | Stacey Haukeland-Parker Øyvind Jervan Waleed Ghanima Martijn A. Spruit René Holst Jostein Gleditsch Mazdak Tavoly Knut Stavem Kjetil Steine Dan Atar Anders Erik Astrup Dahm Frederikus A. Klok Hege Hølmo Johannessen |
| author_sort | Stacey Haukeland-Parker |
| collection | DOAJ |
| description | Background: Exercise is safe and effective in the short-term following pulmonary embolism. To date, little is known about the long-term effects. Objectives: The aim of the study was to investigate whether the effects of exercise-based rehabilitation are maintained 6 months after completion in patients with persistent dyspnea following pulmonary embolism when compared with usual care. Methods: A 2-center, randomized controlled trial compared 8 weeks of exercise-based rehabilitation with usual care. Patients were reassessed postintervention and 6 months later. Exercise capacity was measured with the incremental shuttle walk test (ISWT). Dyspnea was assessed with the Shortness of Breath Questionnaire, and health-related quality of life was assessed with disease-specific (Pulmonary Embolism Quality of Life Questionnaire) and generic questionnaires. Results: In total, 159 of 211 randomized patients attended follow-up 6 months postintervention. The significant improvement on the ISWT in the rehabilitation group was maintained at the 6-month follow-up (96 m; SE: 15 m; 95% CI: 66, 127). There were no changes on the ISWT in the control group at either time point. From postintervention to 6×-month follow-up, the rehabilitation group had further improvements in dyspnea compared with the control group (−3 points; SE: 1.4; 95% CI: −6, −1; P = .02). Health-related quality of life improved in both groups although superior improvements were seen in the rehabilitation group. Conclusion: The improvement in exercise capacity after 8 weeks of exercise-based rehabilitation in patients with pulmonary embolism and persistent dyspnea was maintained at the 6-month follow-up, while no improvement was observed in the control group, highlighting the relevance of offering rehabilitation to these patients. |
| format | Article |
| id | doaj-art-23f1a9163d174e598f3a0bd6f80f89fb |
| institution | OA Journals |
| issn | 2475-0379 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Research and Practice in Thrombosis and Haemostasis |
| spelling | doaj-art-23f1a9163d174e598f3a0bd6f80f89fb2025-08-20T02:12:03ZengElsevierResearch and Practice in Thrombosis and Haemostasis2475-03792025-02-019210273610.1016/j.rpth.2025.102736Exercise capacity, dyspnea, and quality of life 6 months after exercise-based rehabilitation in patients with persistent dyspnea following pulmonary embolismStacey Haukeland-Parker0Øyvind Jervan1Waleed Ghanima2Martijn A. Spruit3René Holst4Jostein Gleditsch5Mazdak Tavoly6Knut Stavem7Kjetil Steine8Dan Atar9Anders Erik Astrup Dahm10Frederikus A. Klok11Hege Hølmo Johannessen12Department of Physical Medicine and Rehabilitation, Østfold Hospital Trust, Grålum, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Correspondence Stacey Haukeland-Parker, Department of Physical Medicine and Rehabilitation, Østfold Hospital Trust, PB 300, 1714 Grålum, Norway.Department of Cardiology, Østfold Hospital Trust, Grålum, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Research, Emergency Medicine and Hematooncology, Østfold Hospital Trust, Grålum, Norway; Department of Hematology, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, NorwayDepartment of Research and Development, CIRO+, Horn, The Netherlands; Department of Respiratory Medicine, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands; NUTRIM Institute of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The NetherlandsDepartment of Research, Emergency Medicine and Hematooncology, Østfold Hospital Trust, Grålum, Norway; Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Radiology, Østfold Hospital Trust, Grålum, NorwayDepartment of Research, Emergency Medicine and Hematooncology, Østfold Hospital Trust, Grålum, Norway; Department of Medicine, Sahlgrenska University Hospital, Gothenberg, SwedenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway; Pulmonary Department, Akershus University Hospital, Lørenskog, Norway; Health Services Research Unit, Akershus University Hospital, Lørenskog, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Cardiology, Medical Division, Akershus University Hospital, Lørenskog, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Cardiology, Oslo University Hospital Ullevål, Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Haemotology, Akershus University Hospital, Lørenskog, NorwayDepartment of Medicine—Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, The NetherlandsInstitute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Health, Welfare and Organization, Østfold University College, Fredrikstad, NorwayBackground: Exercise is safe and effective in the short-term following pulmonary embolism. To date, little is known about the long-term effects. Objectives: The aim of the study was to investigate whether the effects of exercise-based rehabilitation are maintained 6 months after completion in patients with persistent dyspnea following pulmonary embolism when compared with usual care. Methods: A 2-center, randomized controlled trial compared 8 weeks of exercise-based rehabilitation with usual care. Patients were reassessed postintervention and 6 months later. Exercise capacity was measured with the incremental shuttle walk test (ISWT). Dyspnea was assessed with the Shortness of Breath Questionnaire, and health-related quality of life was assessed with disease-specific (Pulmonary Embolism Quality of Life Questionnaire) and generic questionnaires. Results: In total, 159 of 211 randomized patients attended follow-up 6 months postintervention. The significant improvement on the ISWT in the rehabilitation group was maintained at the 6-month follow-up (96 m; SE: 15 m; 95% CI: 66, 127). There were no changes on the ISWT in the control group at either time point. From postintervention to 6×-month follow-up, the rehabilitation group had further improvements in dyspnea compared with the control group (−3 points; SE: 1.4; 95% CI: −6, −1; P = .02). Health-related quality of life improved in both groups although superior improvements were seen in the rehabilitation group. Conclusion: The improvement in exercise capacity after 8 weeks of exercise-based rehabilitation in patients with pulmonary embolism and persistent dyspnea was maintained at the 6-month follow-up, while no improvement was observed in the control group, highlighting the relevance of offering rehabilitation to these patients.http://www.sciencedirect.com/science/article/pii/S2475037925000603dyspneaexercise capacitypulmonary embolismrehabilitationvenous thromboembolism |
| spellingShingle | Stacey Haukeland-Parker Øyvind Jervan Waleed Ghanima Martijn A. Spruit René Holst Jostein Gleditsch Mazdak Tavoly Knut Stavem Kjetil Steine Dan Atar Anders Erik Astrup Dahm Frederikus A. Klok Hege Hølmo Johannessen Exercise capacity, dyspnea, and quality of life 6 months after exercise-based rehabilitation in patients with persistent dyspnea following pulmonary embolism Research and Practice in Thrombosis and Haemostasis dyspnea exercise capacity pulmonary embolism rehabilitation venous thromboembolism |
| title | Exercise capacity, dyspnea, and quality of life 6 months after exercise-based rehabilitation in patients with persistent dyspnea following pulmonary embolism |
| title_full | Exercise capacity, dyspnea, and quality of life 6 months after exercise-based rehabilitation in patients with persistent dyspnea following pulmonary embolism |
| title_fullStr | Exercise capacity, dyspnea, and quality of life 6 months after exercise-based rehabilitation in patients with persistent dyspnea following pulmonary embolism |
| title_full_unstemmed | Exercise capacity, dyspnea, and quality of life 6 months after exercise-based rehabilitation in patients with persistent dyspnea following pulmonary embolism |
| title_short | Exercise capacity, dyspnea, and quality of life 6 months after exercise-based rehabilitation in patients with persistent dyspnea following pulmonary embolism |
| title_sort | exercise capacity dyspnea and quality of life 6 months after exercise based rehabilitation in patients with persistent dyspnea following pulmonary embolism |
| topic | dyspnea exercise capacity pulmonary embolism rehabilitation venous thromboembolism |
| url | http://www.sciencedirect.com/science/article/pii/S2475037925000603 |
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