1,3,4-Oxadiazole derivatives as potent antifungal agents: Synthesis, biological evaluation and an in silico study
Ten 1,3,4-oxadiazole derivatives were prepared and evaluated for their anti-fungal activities. The results showed that compounds 4a, 7a, and 7f displayed activity against F. oxysporum. Molecular docking study indicated that compounds 4a, 7a, and 7f exhibited affinity towards F. oxysporum’s β-tubuli...
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| Format: | Article |
| Language: | English |
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Can Tho University Publisher
2023-11-01
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| Series: | CTU Journal of Innovation and Sustainable Development |
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| Online Access: | https://ctujs.ctu.edu.vn/index.php/ctujs/article/view/669 |
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| _version_ | 1850185151607209984 |
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| author | Quy Nguyen Cuong Quoc Nguyen Quang De Tran Dang Quang Le Thi Buu Hue Bui |
| author_facet | Quy Nguyen Cuong Quoc Nguyen Quang De Tran Dang Quang Le Thi Buu Hue Bui |
| author_sort | Quy Nguyen |
| collection | DOAJ |
| description |
Ten 1,3,4-oxadiazole derivatives were prepared and evaluated for their anti-fungal activities. The results showed that compounds 4a, 7a, and 7f displayed activity against F. oxysporum. Molecular docking study indicated that compounds 4a, 7a, and 7f exhibited affinity towards F. oxysporum’s β-tubulin by showing low binding energies as well as interactions with the key amino acids in the binding sites of the receptor.
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| format | Article |
| id | doaj-art-23f0ed87de7c407bb0116d5d6f58ed1f |
| institution | OA Journals |
| issn | 2588-1418 2815-6412 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Can Tho University Publisher |
| record_format | Article |
| series | CTU Journal of Innovation and Sustainable Development |
| spelling | doaj-art-23f0ed87de7c407bb0116d5d6f58ed1f2025-08-20T02:16:49ZengCan Tho University PublisherCTU Journal of Innovation and Sustainable Development2588-14182815-64122023-11-0115310.22144/ctujoisd.2023.0571,3,4-Oxadiazole derivatives as potent antifungal agents: Synthesis, biological evaluation and an in silico studyQuy Nguyen0Cuong Quoc NguyenQuang De TranDang Quang LeThi Buu Hue Buia:1:{s:5:"en_US";s:17:"Tay Do University";} Ten 1,3,4-oxadiazole derivatives were prepared and evaluated for their anti-fungal activities. The results showed that compounds 4a, 7a, and 7f displayed activity against F. oxysporum. Molecular docking study indicated that compounds 4a, 7a, and 7f exhibited affinity towards F. oxysporum’s β-tubulin by showing low binding energies as well as interactions with the key amino acids in the binding sites of the receptor. https://ctujs.ctu.edu.vn/index.php/ctujs/article/view/669Fungicides, hybrid 1,3,4-oxadiazole/benzimidazole, 1,3,4-oxadiazole, molecular docking. |
| spellingShingle | Quy Nguyen Cuong Quoc Nguyen Quang De Tran Dang Quang Le Thi Buu Hue Bui 1,3,4-Oxadiazole derivatives as potent antifungal agents: Synthesis, biological evaluation and an in silico study CTU Journal of Innovation and Sustainable Development Fungicides, hybrid 1,3,4-oxadiazole/benzimidazole, 1,3,4-oxadiazole, molecular docking. |
| title | 1,3,4-Oxadiazole derivatives as potent antifungal agents: Synthesis, biological evaluation and an in silico study |
| title_full | 1,3,4-Oxadiazole derivatives as potent antifungal agents: Synthesis, biological evaluation and an in silico study |
| title_fullStr | 1,3,4-Oxadiazole derivatives as potent antifungal agents: Synthesis, biological evaluation and an in silico study |
| title_full_unstemmed | 1,3,4-Oxadiazole derivatives as potent antifungal agents: Synthesis, biological evaluation and an in silico study |
| title_short | 1,3,4-Oxadiazole derivatives as potent antifungal agents: Synthesis, biological evaluation and an in silico study |
| title_sort | 1 3 4 oxadiazole derivatives as potent antifungal agents synthesis biological evaluation and an in silico study |
| topic | Fungicides, hybrid 1,3,4-oxadiazole/benzimidazole, 1,3,4-oxadiazole, molecular docking. |
| url | https://ctujs.ctu.edu.vn/index.php/ctujs/article/view/669 |
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