World Health Organization Estimates of the Global and Regional Disease Burden of 11 Foodborne Parasitic Diseases, 2010: A Data Synthesis.
<h4>Background</h4>Foodborne diseases are globally important, resulting in considerable morbidity and mortality. Parasitic diseases often result in high burdens of disease in low and middle income countries and are frequently transmitted to humans via contaminated food. This study presen...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-12-01
|
| Series: | PLoS Medicine |
| Online Access: | https://doi.org/10.1371/journal.pmed.1001920 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850134729836199936 |
|---|---|
| author | Paul R Torgerson Brecht Devleesschauwer Nicolas Praet Niko Speybroeck Arve Lee Willingham Fumiko Kasuga Mohammad B Rokni Xiao-Nong Zhou Eric M Fèvre Banchob Sripa Neyla Gargouri Thomas Fürst Christine M Budke Hélène Carabin Martyn D Kirk Frederick J Angulo Arie Havelaar Nilanthi de Silva |
| author_facet | Paul R Torgerson Brecht Devleesschauwer Nicolas Praet Niko Speybroeck Arve Lee Willingham Fumiko Kasuga Mohammad B Rokni Xiao-Nong Zhou Eric M Fèvre Banchob Sripa Neyla Gargouri Thomas Fürst Christine M Budke Hélène Carabin Martyn D Kirk Frederick J Angulo Arie Havelaar Nilanthi de Silva |
| author_sort | Paul R Torgerson |
| collection | DOAJ |
| description | <h4>Background</h4>Foodborne diseases are globally important, resulting in considerable morbidity and mortality. Parasitic diseases often result in high burdens of disease in low and middle income countries and are frequently transmitted to humans via contaminated food. This study presents the first estimates of the global and regional human disease burden of 10 helminth diseases and toxoplasmosis that may be attributed to contaminated food.<h4>Methods and findings</h4>Data were abstracted from 16 systematic reviews or similar studies published between 2010 and 2015; from 5 disease data bases accessed in 2015; and from 79 reports, 73 of which have been published since 2000, 4 published between 1995 and 2000 and 2 published in 1986 and 1981. These included reports from national surveillance systems, journal articles, and national estimates of foodborne diseases. These data were used to estimate the number of infections, sequelae, deaths, and Disability Adjusted Life Years (DALYs), by age and region for 2010. These parasitic diseases, resulted in 48.4 million cases (95% Uncertainty intervals [UI] of 43.4-79.0 million) and 59,724 (95% UI 48,017-83,616) deaths annually resulting in 8.78 million (95% UI 7.62-12.51 million) DALYs. We estimated that 48% (95% UI 38%-56%) of cases of these parasitic diseases were foodborne, resulting in 76% (95% UI 65%-81%) of the DALYs attributable to these diseases. Overall, foodborne parasitic disease, excluding enteric protozoa, caused an estimated 23.2 million (95% UI 18.2-38.1 million) cases and 45,927 (95% UI 34,763-59,933) deaths annually resulting in an estimated 6.64 million (95% UI 5.61-8.41 million) DALYs. Foodborne Ascaris infection (12.3 million cases, 95% UI 8.29-22.0 million) and foodborne toxoplasmosis (10.3 million cases, 95% UI 7.40-14.9 million) were the most common foodborne parasitic diseases. Human cysticercosis with 2.78 million DALYs (95% UI 2.14-3.61 million), foodborne trematodosis with 2.02 million DALYs (95% UI 1.65-2.48 million) and foodborne toxoplasmosis with 825,000 DALYs (95% UI 561,000-1.26 million) resulted in the highest burdens in terms of DALYs, mainly due to years lived with disability. Foodborne enteric protozoa, reported elsewhere, resulted in an additional 67.2 million illnesses or 492,000 DALYs. Major limitations of our study include often substantial data gaps that had to be filled by imputation and suffer from the uncertainties that surround such models. Due to resource limitations it was also not possible to consider all potentially foodborne parasites (for example Trypanosoma cruzi).<h4>Conclusions</h4>Parasites are frequently transmitted to humans through contaminated food. These estimates represent an important step forward in understanding the impact of foodborne diseases globally and regionally. The disease burden due to most foodborne parasites is highly focal and results in significant morbidity and mortality among vulnerable populations. |
| format | Article |
| id | doaj-art-23ee570e393943faa790861e299b5ea1 |
| institution | OA Journals |
| issn | 1549-1277 1549-1676 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Medicine |
| spelling | doaj-art-23ee570e393943faa790861e299b5ea12025-08-20T02:31:39ZengPublic Library of Science (PLoS)PLoS Medicine1549-12771549-16762015-12-011212e100192010.1371/journal.pmed.1001920World Health Organization Estimates of the Global and Regional Disease Burden of 11 Foodborne Parasitic Diseases, 2010: A Data Synthesis.Paul R TorgersonBrecht DevleesschauwerNicolas PraetNiko SpeybroeckArve Lee WillinghamFumiko KasugaMohammad B RokniXiao-Nong ZhouEric M FèvreBanchob SripaNeyla GargouriThomas FürstChristine M BudkeHélène CarabinMartyn D KirkFrederick J AnguloArie HavelaarNilanthi de Silva<h4>Background</h4>Foodborne diseases are globally important, resulting in considerable morbidity and mortality. Parasitic diseases often result in high burdens of disease in low and middle income countries and are frequently transmitted to humans via contaminated food. This study presents the first estimates of the global and regional human disease burden of 10 helminth diseases and toxoplasmosis that may be attributed to contaminated food.<h4>Methods and findings</h4>Data were abstracted from 16 systematic reviews or similar studies published between 2010 and 2015; from 5 disease data bases accessed in 2015; and from 79 reports, 73 of which have been published since 2000, 4 published between 1995 and 2000 and 2 published in 1986 and 1981. These included reports from national surveillance systems, journal articles, and national estimates of foodborne diseases. These data were used to estimate the number of infections, sequelae, deaths, and Disability Adjusted Life Years (DALYs), by age and region for 2010. These parasitic diseases, resulted in 48.4 million cases (95% Uncertainty intervals [UI] of 43.4-79.0 million) and 59,724 (95% UI 48,017-83,616) deaths annually resulting in 8.78 million (95% UI 7.62-12.51 million) DALYs. We estimated that 48% (95% UI 38%-56%) of cases of these parasitic diseases were foodborne, resulting in 76% (95% UI 65%-81%) of the DALYs attributable to these diseases. Overall, foodborne parasitic disease, excluding enteric protozoa, caused an estimated 23.2 million (95% UI 18.2-38.1 million) cases and 45,927 (95% UI 34,763-59,933) deaths annually resulting in an estimated 6.64 million (95% UI 5.61-8.41 million) DALYs. Foodborne Ascaris infection (12.3 million cases, 95% UI 8.29-22.0 million) and foodborne toxoplasmosis (10.3 million cases, 95% UI 7.40-14.9 million) were the most common foodborne parasitic diseases. Human cysticercosis with 2.78 million DALYs (95% UI 2.14-3.61 million), foodborne trematodosis with 2.02 million DALYs (95% UI 1.65-2.48 million) and foodborne toxoplasmosis with 825,000 DALYs (95% UI 561,000-1.26 million) resulted in the highest burdens in terms of DALYs, mainly due to years lived with disability. Foodborne enteric protozoa, reported elsewhere, resulted in an additional 67.2 million illnesses or 492,000 DALYs. Major limitations of our study include often substantial data gaps that had to be filled by imputation and suffer from the uncertainties that surround such models. Due to resource limitations it was also not possible to consider all potentially foodborne parasites (for example Trypanosoma cruzi).<h4>Conclusions</h4>Parasites are frequently transmitted to humans through contaminated food. These estimates represent an important step forward in understanding the impact of foodborne diseases globally and regionally. The disease burden due to most foodborne parasites is highly focal and results in significant morbidity and mortality among vulnerable populations.https://doi.org/10.1371/journal.pmed.1001920 |
| spellingShingle | Paul R Torgerson Brecht Devleesschauwer Nicolas Praet Niko Speybroeck Arve Lee Willingham Fumiko Kasuga Mohammad B Rokni Xiao-Nong Zhou Eric M Fèvre Banchob Sripa Neyla Gargouri Thomas Fürst Christine M Budke Hélène Carabin Martyn D Kirk Frederick J Angulo Arie Havelaar Nilanthi de Silva World Health Organization Estimates of the Global and Regional Disease Burden of 11 Foodborne Parasitic Diseases, 2010: A Data Synthesis. PLoS Medicine |
| title | World Health Organization Estimates of the Global and Regional Disease Burden of 11 Foodborne Parasitic Diseases, 2010: A Data Synthesis. |
| title_full | World Health Organization Estimates of the Global and Regional Disease Burden of 11 Foodborne Parasitic Diseases, 2010: A Data Synthesis. |
| title_fullStr | World Health Organization Estimates of the Global and Regional Disease Burden of 11 Foodborne Parasitic Diseases, 2010: A Data Synthesis. |
| title_full_unstemmed | World Health Organization Estimates of the Global and Regional Disease Burden of 11 Foodborne Parasitic Diseases, 2010: A Data Synthesis. |
| title_short | World Health Organization Estimates of the Global and Regional Disease Burden of 11 Foodborne Parasitic Diseases, 2010: A Data Synthesis. |
| title_sort | world health organization estimates of the global and regional disease burden of 11 foodborne parasitic diseases 2010 a data synthesis |
| url | https://doi.org/10.1371/journal.pmed.1001920 |
| work_keys_str_mv | AT paulrtorgerson worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis AT brechtdevleesschauwer worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis AT nicolaspraet worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis AT nikospeybroeck worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis AT arveleewillingham worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis AT fumikokasuga worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis AT mohammadbrokni worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis AT xiaonongzhou worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis AT ericmfevre worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis AT banchobsripa worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis AT neylagargouri worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis AT thomasfurst worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis AT christinembudke worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis AT helenecarabin worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis AT martyndkirk worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis AT frederickjangulo worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis AT ariehavelaar worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis AT nilanthidesilva worldhealthorganizationestimatesoftheglobalandregionaldiseaseburdenof11foodborneparasiticdiseases2010adatasynthesis |