Outcomes of autologous chondrocyte transplantation (ACT) and autologous matrix-induced chondrogenesis (AMIC) in the hip: a systematic review and meta-analysis
Abstract Background Appropriate treatment of chondral lesions in the hip greatly improves symptoms and reduces the need for early joint replacement in these patients. Whilst the outcomes of Autologous Chondrocyte Transplantation (ACT) and Autologous Matrix Induced Chondrogenesis (AMIC) in the knee h...
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BMC
2025-05-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Online Access: | https://doi.org/10.1186/s13018-025-05862-5 |
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| author | Thomas Walker Maximilian Dewhurst Peter Bates |
| author_facet | Thomas Walker Maximilian Dewhurst Peter Bates |
| author_sort | Thomas Walker |
| collection | DOAJ |
| description | Abstract Background Appropriate treatment of chondral lesions in the hip greatly improves symptoms and reduces the need for early joint replacement in these patients. Whilst the outcomes of Autologous Chondrocyte Transplantation (ACT) and Autologous Matrix Induced Chondrogenesis (AMIC) in the knee have been thoroughly researched, data on these treatments in the hip is comparatively limited. Aim To evaluate the outcomes of ACT and AMIC in the hip. Methods Following PRISMA guidelines, a literature search was performed using free text and MeSH terms relating to ACT, AMIC, and variations of these terms across 6 databases. This resulted in 506 abstracts, which were screened down to 12 papers which met the eligibility criteria. Weighted means and pooled estimates using a random effects model were used to assess the success of both procedures. Results 628 hips were identified within 12 papers. Weighted mean age 35.8 years (18–55 years), weighted mean lesion size 3.3 cm2 (2.2–5.1 cm2)., weighted mean follow-up 46.9 months (6–96 months). Improvement in mHHS was measured for both interventions, with a mean improvement of 31.1 points following ACT and 35.8 following AMIC. The pooled success rate for AMIC (99.6% [95% CI, 99.0-100.0%]) was higher than that for ACT (98.3% [95% CI, 96.4-100.0%]). All PROs assessed showed statistically significant postoperative improvements. Conclusion Both techniques produced significant improvements from baseline. Due to the treatment characteristics, we suggest AMIC is a preferable treatment to ACT. Further research is required to assess the limitations of these procedures concerning chondral lesion size and duration of symptom improvement. |
| format | Article |
| id | doaj-art-23ebecfcb82449a0ba0ff86b5d6e4288 |
| institution | OA Journals |
| issn | 1749-799X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
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| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj-art-23ebecfcb82449a0ba0ff86b5d6e42882025-08-20T01:53:19ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2025-05-0120111310.1186/s13018-025-05862-5Outcomes of autologous chondrocyte transplantation (ACT) and autologous matrix-induced chondrogenesis (AMIC) in the hip: a systematic review and meta-analysisThomas Walker0Maximilian Dewhurst1Peter Bates2Centre for Trauma Science, Blizard Institute, Queen Mary University of LondonCentre for Trauma Science, Blizard Institute, Queen Mary University of LondonCentre for Trauma Science, Blizard Institute, Queen Mary University of LondonAbstract Background Appropriate treatment of chondral lesions in the hip greatly improves symptoms and reduces the need for early joint replacement in these patients. Whilst the outcomes of Autologous Chondrocyte Transplantation (ACT) and Autologous Matrix Induced Chondrogenesis (AMIC) in the knee have been thoroughly researched, data on these treatments in the hip is comparatively limited. Aim To evaluate the outcomes of ACT and AMIC in the hip. Methods Following PRISMA guidelines, a literature search was performed using free text and MeSH terms relating to ACT, AMIC, and variations of these terms across 6 databases. This resulted in 506 abstracts, which were screened down to 12 papers which met the eligibility criteria. Weighted means and pooled estimates using a random effects model were used to assess the success of both procedures. Results 628 hips were identified within 12 papers. Weighted mean age 35.8 years (18–55 years), weighted mean lesion size 3.3 cm2 (2.2–5.1 cm2)., weighted mean follow-up 46.9 months (6–96 months). Improvement in mHHS was measured for both interventions, with a mean improvement of 31.1 points following ACT and 35.8 following AMIC. The pooled success rate for AMIC (99.6% [95% CI, 99.0-100.0%]) was higher than that for ACT (98.3% [95% CI, 96.4-100.0%]). All PROs assessed showed statistically significant postoperative improvements. Conclusion Both techniques produced significant improvements from baseline. Due to the treatment characteristics, we suggest AMIC is a preferable treatment to ACT. Further research is required to assess the limitations of these procedures concerning chondral lesion size and duration of symptom improvement.https://doi.org/10.1186/s13018-025-05862-5 |
| spellingShingle | Thomas Walker Maximilian Dewhurst Peter Bates Outcomes of autologous chondrocyte transplantation (ACT) and autologous matrix-induced chondrogenesis (AMIC) in the hip: a systematic review and meta-analysis Journal of Orthopaedic Surgery and Research |
| title | Outcomes of autologous chondrocyte transplantation (ACT) and autologous matrix-induced chondrogenesis (AMIC) in the hip: a systematic review and meta-analysis |
| title_full | Outcomes of autologous chondrocyte transplantation (ACT) and autologous matrix-induced chondrogenesis (AMIC) in the hip: a systematic review and meta-analysis |
| title_fullStr | Outcomes of autologous chondrocyte transplantation (ACT) and autologous matrix-induced chondrogenesis (AMIC) in the hip: a systematic review and meta-analysis |
| title_full_unstemmed | Outcomes of autologous chondrocyte transplantation (ACT) and autologous matrix-induced chondrogenesis (AMIC) in the hip: a systematic review and meta-analysis |
| title_short | Outcomes of autologous chondrocyte transplantation (ACT) and autologous matrix-induced chondrogenesis (AMIC) in the hip: a systematic review and meta-analysis |
| title_sort | outcomes of autologous chondrocyte transplantation act and autologous matrix induced chondrogenesis amic in the hip a systematic review and meta analysis |
| url | https://doi.org/10.1186/s13018-025-05862-5 |
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