Echocardiographic assessment of left cardiac structure and function in antiretroviral therapy (ART)‐naïve people living with HIV/AIDS
Abstract Background Patients with human immunodeficiency virus (HIV) are at a significantly higher risk of cardiovascular disease (CVD) compared to HIV‐negative people. Left heart dysfunction is the most common cardiac complication in people living with HIV/acquired immune deficiency syndrome (PLWHA...
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.799 |
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| author | Xing Hu Yuan Zhang Tong Zhang Weihua Li Jing Han Xuhui Zhang Fankun Meng |
| author_facet | Xing Hu Yuan Zhang Tong Zhang Weihua Li Jing Han Xuhui Zhang Fankun Meng |
| author_sort | Xing Hu |
| collection | DOAJ |
| description | Abstract Background Patients with human immunodeficiency virus (HIV) are at a significantly higher risk of cardiovascular disease (CVD) compared to HIV‐negative people. Left heart dysfunction is the most common cardiac complication in people living with HIV/acquired immune deficiency syndrome (PLWHA), and diastolic dysfunction is an important predictor of cardiovascular events. The aims of this study were (1) to detect changes in left cardiac structure and function in antiretroviral therapy (ART)‐naive PLWHA using echocardiography; and (2) to investigate the risk factors for the development of left ventricular diastolic dysfunction (LVDD) in ART‐naive PLWHA. Methods We retrospectively included 105 ART‐naïve PLWHA and included 90 healthy subjects as controls to compare the differences in left heart structure and function between the two groups. Univariate and multifactorial logistic regression were employed to explore the risk factors of the development of LVDD in ART‐naive PLWHA. Results The left ventricular end‐diastolic internal diameter (LVEDD), left ventricular mass index (LVMI), and left atrial volume index (LAVI) were significantly greater in PLWHA than in controls (p < .05). The E/A ratio, lateral e′ velocity, and mitral deceleration time were significantly lower in PLWHA than in controls (p < .05). Average E/e′ ratio was significantly higher in PLWHA than in controls (p < .05). Left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were not significantly different between PLWHA and controls (p > .05). Multifactorial logistic regression analysis showed that age, body mass index (BMI), and CD4+ count <200 cells/μL were independent risk factors for LVDD in ART‐naive PLWHA (OR = 1.781, 1.228, 3.683, p < .05). Conclusions Left ventricular systolic function did not differ between PLWHA and controls, and left ventricular diastolic function was lower in PLWHA than in controls. Age, BMI, and CD4+ count were independent factors affecting LVDD in ART‐naive PLWHA. |
| format | Article |
| id | doaj-art-23eaa0efd5cb4814930d01aed686af41 |
| institution | OA Journals |
| issn | 2050-4527 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-23eaa0efd5cb4814930d01aed686af412025-08-20T02:16:50ZengWileyImmunity, Inflammation and Disease2050-45272023-04-01114n/an/a10.1002/iid3.799Echocardiographic assessment of left cardiac structure and function in antiretroviral therapy (ART)‐naïve people living with HIV/AIDSXing Hu0Yuan Zhang1Tong Zhang2Weihua Li3Jing Han4Xuhui Zhang5Fankun Meng6Ultrasound and Functional Diagnosis Center, Beijing Youan Hospital Capital Medical University Beijing ChinaUltrasound and Functional Diagnosis Center, Beijing Youan Hospital Capital Medical University Beijing ChinaCenter for Infectious Disease, Beijing Youan Hospital Capital Medical University Beijing ChinaBeijing Institute of Hepatology, Beijing Youan Hospital Capital Medical University Beijing ChinaUltrasound and Functional Diagnosis Center, Beijing Youan Hospital Capital Medical University Beijing ChinaUltrasound and Functional Diagnosis Center, Beijing Youan Hospital Capital Medical University Beijing ChinaUltrasound and Functional Diagnosis Center, Beijing Youan Hospital Capital Medical University Beijing ChinaAbstract Background Patients with human immunodeficiency virus (HIV) are at a significantly higher risk of cardiovascular disease (CVD) compared to HIV‐negative people. Left heart dysfunction is the most common cardiac complication in people living with HIV/acquired immune deficiency syndrome (PLWHA), and diastolic dysfunction is an important predictor of cardiovascular events. The aims of this study were (1) to detect changes in left cardiac structure and function in antiretroviral therapy (ART)‐naive PLWHA using echocardiography; and (2) to investigate the risk factors for the development of left ventricular diastolic dysfunction (LVDD) in ART‐naive PLWHA. Methods We retrospectively included 105 ART‐naïve PLWHA and included 90 healthy subjects as controls to compare the differences in left heart structure and function between the two groups. Univariate and multifactorial logistic regression were employed to explore the risk factors of the development of LVDD in ART‐naive PLWHA. Results The left ventricular end‐diastolic internal diameter (LVEDD), left ventricular mass index (LVMI), and left atrial volume index (LAVI) were significantly greater in PLWHA than in controls (p < .05). The E/A ratio, lateral e′ velocity, and mitral deceleration time were significantly lower in PLWHA than in controls (p < .05). Average E/e′ ratio was significantly higher in PLWHA than in controls (p < .05). Left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were not significantly different between PLWHA and controls (p > .05). Multifactorial logistic regression analysis showed that age, body mass index (BMI), and CD4+ count <200 cells/μL were independent risk factors for LVDD in ART‐naive PLWHA (OR = 1.781, 1.228, 3.683, p < .05). Conclusions Left ventricular systolic function did not differ between PLWHA and controls, and left ventricular diastolic function was lower in PLWHA than in controls. Age, BMI, and CD4+ count were independent factors affecting LVDD in ART‐naive PLWHA.https://doi.org/10.1002/iid3.799acquired immune deficiency syndromecardiac function echocardiographyhuman immunodeficiency virusleft ventricular diastolic dysfunction |
| spellingShingle | Xing Hu Yuan Zhang Tong Zhang Weihua Li Jing Han Xuhui Zhang Fankun Meng Echocardiographic assessment of left cardiac structure and function in antiretroviral therapy (ART)‐naïve people living with HIV/AIDS Immunity, Inflammation and Disease acquired immune deficiency syndrome cardiac function echocardiography human immunodeficiency virus left ventricular diastolic dysfunction |
| title | Echocardiographic assessment of left cardiac structure and function in antiretroviral therapy (ART)‐naïve people living with HIV/AIDS |
| title_full | Echocardiographic assessment of left cardiac structure and function in antiretroviral therapy (ART)‐naïve people living with HIV/AIDS |
| title_fullStr | Echocardiographic assessment of left cardiac structure and function in antiretroviral therapy (ART)‐naïve people living with HIV/AIDS |
| title_full_unstemmed | Echocardiographic assessment of left cardiac structure and function in antiretroviral therapy (ART)‐naïve people living with HIV/AIDS |
| title_short | Echocardiographic assessment of left cardiac structure and function in antiretroviral therapy (ART)‐naïve people living with HIV/AIDS |
| title_sort | echocardiographic assessment of left cardiac structure and function in antiretroviral therapy art naive people living with hiv aids |
| topic | acquired immune deficiency syndrome cardiac function echocardiography human immunodeficiency virus left ventricular diastolic dysfunction |
| url | https://doi.org/10.1002/iid3.799 |
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