Pregametogenesis: The Earliest Stages of Gonad and Germline Differentiation in Anuran Amphibians
The gonads of amphibians, like other vertebrates, consist of somatic tissues, which create a specific environment essential for the differentiation of germline cells. The earliest stages of gametogenesis still remain underexplored in anuran amphibians. We propose to introduce the term “pregametogene...
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2024-12-01
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| author | Maria Ogielska Magdalena Chmielewska Beata Rozenblut-Kościsty |
| author_facet | Maria Ogielska Magdalena Chmielewska Beata Rozenblut-Kościsty |
| author_sort | Maria Ogielska |
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| description | The gonads of amphibians, like other vertebrates, consist of somatic tissues, which create a specific environment essential for the differentiation of germline cells. The earliest stages of gametogenesis still remain underexplored in anuran amphibians. We propose to introduce the term “pregametogenesis” for a specific period of gonocyte proliferation and differentiation that occurs exclusively during the early stages of gonadal development. This review shows the key steps of early gonad differentiation in anuran amphibians and further compares chromatin reorganization in gonocytes of mammals and hybridogenetic water frogs. In mammals, this phase involves resetting genomic imprinting, which is crucial for determining gene expression in offspring. In hybridogenetic <i>Pelophylax</i> water frogs, we highlight the unique phenomenon of genome elimination, where one parental subgenome is eliminated while the other is replicated. This process, occurring at the same developmental phase as imprinting in mammals, underscores the evolutionary importance of pregametogenesis. The study of amphibian gonocytes provides valuable insights into chromatin reorganization and genome plasticity, offering new perspectives on reproductive biology. |
| format | Article |
| id | doaj-art-23e4dc5e85b74e3b8ad617f1aadbb285 |
| institution | DOAJ |
| issn | 2079-7737 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Biology |
| spelling | doaj-art-23e4dc5e85b74e3b8ad617f1aadbb2852025-08-20T02:43:28ZengMDPI AGBiology2079-77372024-12-011312101710.3390/biology13121017Pregametogenesis: The Earliest Stages of Gonad and Germline Differentiation in Anuran AmphibiansMaria Ogielska0Magdalena Chmielewska1Beata Rozenblut-Kościsty2Amphibian Biology Group, Department of Evolutionary Biology and Conservation of Vertebrates, Faculty of Biological Sciences, University of Wrocław, Sienkiewicza 21, 50-335 Wrocław, PolandAmphibian Biology Group, Department of Evolutionary Biology and Conservation of Vertebrates, Faculty of Biological Sciences, University of Wrocław, Sienkiewicza 21, 50-335 Wrocław, PolandAmphibian Biology Group, Department of Evolutionary Biology and Conservation of Vertebrates, Faculty of Biological Sciences, University of Wrocław, Sienkiewicza 21, 50-335 Wrocław, PolandThe gonads of amphibians, like other vertebrates, consist of somatic tissues, which create a specific environment essential for the differentiation of germline cells. The earliest stages of gametogenesis still remain underexplored in anuran amphibians. We propose to introduce the term “pregametogenesis” for a specific period of gonocyte proliferation and differentiation that occurs exclusively during the early stages of gonadal development. This review shows the key steps of early gonad differentiation in anuran amphibians and further compares chromatin reorganization in gonocytes of mammals and hybridogenetic water frogs. In mammals, this phase involves resetting genomic imprinting, which is crucial for determining gene expression in offspring. In hybridogenetic <i>Pelophylax</i> water frogs, we highlight the unique phenomenon of genome elimination, where one parental subgenome is eliminated while the other is replicated. This process, occurring at the same developmental phase as imprinting in mammals, underscores the evolutionary importance of pregametogenesis. The study of amphibian gonocytes provides valuable insights into chromatin reorganization and genome plasticity, offering new perspectives on reproductive biology.https://www.mdpi.com/2079-7737/13/12/1017pregametogenesisgonocytesgonad developmentanuran amphibiansspermatogenesisoogenesis |
| spellingShingle | Maria Ogielska Magdalena Chmielewska Beata Rozenblut-Kościsty Pregametogenesis: The Earliest Stages of Gonad and Germline Differentiation in Anuran Amphibians Biology pregametogenesis gonocytes gonad development anuran amphibians spermatogenesis oogenesis |
| title | Pregametogenesis: The Earliest Stages of Gonad and Germline Differentiation in Anuran Amphibians |
| title_full | Pregametogenesis: The Earliest Stages of Gonad and Germline Differentiation in Anuran Amphibians |
| title_fullStr | Pregametogenesis: The Earliest Stages of Gonad and Germline Differentiation in Anuran Amphibians |
| title_full_unstemmed | Pregametogenesis: The Earliest Stages of Gonad and Germline Differentiation in Anuran Amphibians |
| title_short | Pregametogenesis: The Earliest Stages of Gonad and Germline Differentiation in Anuran Amphibians |
| title_sort | pregametogenesis the earliest stages of gonad and germline differentiation in anuran amphibians |
| topic | pregametogenesis gonocytes gonad development anuran amphibians spermatogenesis oogenesis |
| url | https://www.mdpi.com/2079-7737/13/12/1017 |
| work_keys_str_mv | AT mariaogielska pregametogenesistheearlieststagesofgonadandgermlinedifferentiationinanuranamphibians AT magdalenachmielewska pregametogenesistheearlieststagesofgonadandgermlinedifferentiationinanuranamphibians AT beatarozenblutkoscisty pregametogenesistheearlieststagesofgonadandgermlinedifferentiationinanuranamphibians |