Hepatitis C virus infection protein network
Abstract A proteome‐wide mapping of interactions between hepatitis C virus (HCV) and human proteins was performed to provide a comprehensive view of the cellular infection. A total of 314 protein–protein interactions between HCV and human proteins was identified by yeast two‐hybrid and 170 by litera...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer Nature
2008-11-01
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| Series: | Molecular Systems Biology |
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| Online Access: | https://doi.org/10.1038/msb.2008.66 |
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| author | B de Chassey V Navratil L Tafforeau M S Hiet A Aublin‐Gex S Agaugué G Meiffren F Pradezynski B F Faria T Chantier M Le Breton J Pellet N Davoust P E Mangeot A Chaboud F Penin Y Jacob P O Vidalain M Vidal P André C Rabourdin‐Combe V Lotteau |
| author_facet | B de Chassey V Navratil L Tafforeau M S Hiet A Aublin‐Gex S Agaugué G Meiffren F Pradezynski B F Faria T Chantier M Le Breton J Pellet N Davoust P E Mangeot A Chaboud F Penin Y Jacob P O Vidalain M Vidal P André C Rabourdin‐Combe V Lotteau |
| author_sort | B de Chassey |
| collection | DOAJ |
| description | Abstract A proteome‐wide mapping of interactions between hepatitis C virus (HCV) and human proteins was performed to provide a comprehensive view of the cellular infection. A total of 314 protein–protein interactions between HCV and human proteins was identified by yeast two‐hybrid and 170 by literature mining. Integration of this data set into a reconstructed human interactome showed that cellular proteins interacting with HCV are enriched in highly central and interconnected proteins. A global analysis on the basis of functional annotation highlighted the enrichment of cellular pathways targeted by HCV. A network of proteins associated with frequent clinical disorders of chronically infected patients was constructed by connecting the insulin, Jak/STAT and TGFβ pathways with cellular proteins targeted by HCV. CORE protein appeared as a major perturbator of this network. Focal adhesion was identified as a new function affected by HCV, mainly by NS3 and NS5A proteins. |
| format | Article |
| id | doaj-art-23e0c5b48c2d435baadbafb62496d7eb |
| institution | Kabale University |
| issn | 1744-4292 |
| language | English |
| publishDate | 2008-11-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | Molecular Systems Biology |
| spelling | doaj-art-23e0c5b48c2d435baadbafb62496d7eb2025-08-24T12:01:41ZengSpringer NatureMolecular Systems Biology1744-42922008-11-014111210.1038/msb.2008.66Hepatitis C virus infection protein networkB de Chassey0V Navratil1L Tafforeau2M S Hiet3A Aublin‐Gex4S Agaugué5G Meiffren6F Pradezynski7B F Faria8T Chantier9M Le Breton10J Pellet11N Davoust12P E Mangeot13A Chaboud14F Penin15Y Jacob16P O Vidalain17M Vidal18P André19C Rabourdin‐Combe20V Lotteau21IMAP TeamIFR128 BioSciences Lyon‐Gerland, Université de LyonIMAP TeamIMAP TeamIMAP TeamIMAP TeamIMAP TeamIMAP TeamIMAP TeamIMAP TeamIMAP TeamIMAP TeamIMAP TeamIMAP TeamIFR128 BioSciences Lyon‐Gerland, Université de LyonIFR128 BioSciences Lyon‐Gerland, Université de LyonUnité Postulante de Génétique, Papillomavirus et Cancer Humain, Institut PasteurLaboratoire de Génomique Virale et Vaccination, Institut PasteurCenter for Cancer Systems Biology, Dana‐Farber Cancer Institute, Harvard Medical SchoolIMAP TeamIMAP TeamIMAP TeamAbstract A proteome‐wide mapping of interactions between hepatitis C virus (HCV) and human proteins was performed to provide a comprehensive view of the cellular infection. A total of 314 protein–protein interactions between HCV and human proteins was identified by yeast two‐hybrid and 170 by literature mining. Integration of this data set into a reconstructed human interactome showed that cellular proteins interacting with HCV are enriched in highly central and interconnected proteins. A global analysis on the basis of functional annotation highlighted the enrichment of cellular pathways targeted by HCV. A network of proteins associated with frequent clinical disorders of chronically infected patients was constructed by connecting the insulin, Jak/STAT and TGFβ pathways with cellular proteins targeted by HCV. CORE protein appeared as a major perturbator of this network. Focal adhesion was identified as a new function affected by HCV, mainly by NS3 and NS5A proteins.https://doi.org/10.1038/msb.2008.66functional analysishepatitis Cinteractomevirus‐host cell |
| spellingShingle | B de Chassey V Navratil L Tafforeau M S Hiet A Aublin‐Gex S Agaugué G Meiffren F Pradezynski B F Faria T Chantier M Le Breton J Pellet N Davoust P E Mangeot A Chaboud F Penin Y Jacob P O Vidalain M Vidal P André C Rabourdin‐Combe V Lotteau Hepatitis C virus infection protein network Molecular Systems Biology functional analysis hepatitis C interactome virus‐host cell |
| title | Hepatitis C virus infection protein network |
| title_full | Hepatitis C virus infection protein network |
| title_fullStr | Hepatitis C virus infection protein network |
| title_full_unstemmed | Hepatitis C virus infection protein network |
| title_short | Hepatitis C virus infection protein network |
| title_sort | hepatitis c virus infection protein network |
| topic | functional analysis hepatitis C interactome virus‐host cell |
| url | https://doi.org/10.1038/msb.2008.66 |
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