Preoperative High-Dose Steroid Has Long-Term Beneficial Effects for Myasthenia Gravis
Previous studies addressing preoperative steroid treatment have revealed that control of myasthenia gravis (MG) with steroids prior to surgery appeared to stabilize postoperative status. The purpose of our study was to clarify the clinical benefits of the preoperative programmed high-dose steroid tr...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2013/709480 |
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| author | Syuichi Tetsuka Ken-ichi Fujimoto Kunihiko Ikeguchi |
| author_facet | Syuichi Tetsuka Ken-ichi Fujimoto Kunihiko Ikeguchi |
| author_sort | Syuichi Tetsuka |
| collection | DOAJ |
| description | Previous studies addressing preoperative steroid treatment have revealed that control of myasthenia gravis (MG) with steroids prior to surgery appeared to stabilize postoperative status. The purpose of our study was to clarify the clinical benefits of the preoperative programmed high-dose steroid treatment on the long-term outcomes of MG patients. We retrospectively reviewed the records of 171 MG patients who were followed up after undergoing thymectomy in our hospital between 1988 and 2006. One hundred and thirteen patients in the programmed treatment group had received preoperative steroid treatment, while 58 patients received no steroid treatment during the preoperative period. Clinical remission, which was defined as the achievement of the modified pharmacologic remission (PR) for at least 1 year, and clinical benefits were compared between the two groups. With regard to the remission after thymectomy, Kaplan-Meier life-table curves for patients in the preoperative steroid treatment group versus those for patients in the no steroid preoperative treatment group revealed a significantly higher probability of the PR in the preoperative steroid treatment group (log-rank test, P<0.01). This study might be the first, as per our knowledge, to indicate that preoperative programmed high-dose steroid treatment has long-term beneficial effects for MG patients. |
| format | Article |
| id | doaj-art-23dffaf2ef9248758779645ac6f91e3e |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-23dffaf2ef9248758779645ac6f91e3e2025-08-20T03:54:57ZengWileyNeurology Research International2090-18522090-18602013-01-01201310.1155/2013/709480709480Preoperative High-Dose Steroid Has Long-Term Beneficial Effects for Myasthenia GravisSyuichi Tetsuka0Ken-ichi Fujimoto1Kunihiko Ikeguchi2Division of Neurology, Department of Internal Medicine, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi 329-0498, JapanDivision of Neurology, Department of Internal Medicine, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi 329-0498, JapanDivision of Neurology, Department of Internal Medicine, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi 329-0498, JapanPrevious studies addressing preoperative steroid treatment have revealed that control of myasthenia gravis (MG) with steroids prior to surgery appeared to stabilize postoperative status. The purpose of our study was to clarify the clinical benefits of the preoperative programmed high-dose steroid treatment on the long-term outcomes of MG patients. We retrospectively reviewed the records of 171 MG patients who were followed up after undergoing thymectomy in our hospital between 1988 and 2006. One hundred and thirteen patients in the programmed treatment group had received preoperative steroid treatment, while 58 patients received no steroid treatment during the preoperative period. Clinical remission, which was defined as the achievement of the modified pharmacologic remission (PR) for at least 1 year, and clinical benefits were compared between the two groups. With regard to the remission after thymectomy, Kaplan-Meier life-table curves for patients in the preoperative steroid treatment group versus those for patients in the no steroid preoperative treatment group revealed a significantly higher probability of the PR in the preoperative steroid treatment group (log-rank test, P<0.01). This study might be the first, as per our knowledge, to indicate that preoperative programmed high-dose steroid treatment has long-term beneficial effects for MG patients.http://dx.doi.org/10.1155/2013/709480 |
| spellingShingle | Syuichi Tetsuka Ken-ichi Fujimoto Kunihiko Ikeguchi Preoperative High-Dose Steroid Has Long-Term Beneficial Effects for Myasthenia Gravis Neurology Research International |
| title | Preoperative High-Dose Steroid Has Long-Term Beneficial Effects for Myasthenia Gravis |
| title_full | Preoperative High-Dose Steroid Has Long-Term Beneficial Effects for Myasthenia Gravis |
| title_fullStr | Preoperative High-Dose Steroid Has Long-Term Beneficial Effects for Myasthenia Gravis |
| title_full_unstemmed | Preoperative High-Dose Steroid Has Long-Term Beneficial Effects for Myasthenia Gravis |
| title_short | Preoperative High-Dose Steroid Has Long-Term Beneficial Effects for Myasthenia Gravis |
| title_sort | preoperative high dose steroid has long term beneficial effects for myasthenia gravis |
| url | http://dx.doi.org/10.1155/2013/709480 |
| work_keys_str_mv | AT syuichitetsuka preoperativehighdosesteroidhaslongtermbeneficialeffectsformyastheniagravis AT kenichifujimoto preoperativehighdosesteroidhaslongtermbeneficialeffectsformyastheniagravis AT kunihikoikeguchi preoperativehighdosesteroidhaslongtermbeneficialeffectsformyastheniagravis |