Primary treatment of chronic pulmonary aspergillosis with weekly liposomal amphotericin B: A case report from Uganda
Chronic pulmonary aspergillosis (CPA) treatment in Africa remains unexplored. We present a 23-year-old Ugandan male, previously treated thrice for pulmonary tuberculosis, developing CPA. Imaging showed lung fibrosis, bronchiectasis, and a fungal ball. He received weekly 600mg (10mg/kg) of liposomal...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Medical Mycology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221175392400040X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850254854240337920 |
|---|---|
| author | Winnie Kibone Felix Bongomin David W. Denning David B. Meya |
| author_facet | Winnie Kibone Felix Bongomin David W. Denning David B. Meya |
| author_sort | Winnie Kibone |
| collection | DOAJ |
| description | Chronic pulmonary aspergillosis (CPA) treatment in Africa remains unexplored. We present a 23-year-old Ugandan male, previously treated thrice for pulmonary tuberculosis, developing CPA. Imaging showed lung fibrosis, bronchiectasis, and a fungal ball. He received weekly 600mg (10mg/kg) of liposomal amphotericin B for six weeks, leading to marked clinical improvement. Weekly liposomal amphotericin B may be a viable treatment option for CPA in resource-limited settings. |
| format | Article |
| id | doaj-art-23df447333a448a89c0ef87b8ef100cd |
| institution | OA Journals |
| issn | 2211-7539 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medical Mycology Case Reports |
| spelling | doaj-art-23df447333a448a89c0ef87b8ef100cd2025-08-20T01:57:01ZengElsevierMedical Mycology Case Reports2211-75392024-12-014610066610.1016/j.mmcr.2024.100666Primary treatment of chronic pulmonary aspergillosis with weekly liposomal amphotericin B: A case report from UgandaWinnie Kibone0Felix Bongomin1David W. Denning2David B. Meya3Department of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, Gulu, Uganda; Department of Internal Medicine, Mulago National Referral Hospital, Kampala, Uganda; Corresponding author. Department of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, Gulu, Uganda.Department of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, Gulu, Uganda; Manchester Fungal Infection Group, Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United KingdomManchester Fungal Infection Group, Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United KingdomDepartment of Internal Medicine, Mulago National Referral Hospital, Kampala, Uganda; Infectious Diseases Institute, Department of Medicine, College of Health Sciences, Makerere University, Kampala, UgandaChronic pulmonary aspergillosis (CPA) treatment in Africa remains unexplored. We present a 23-year-old Ugandan male, previously treated thrice for pulmonary tuberculosis, developing CPA. Imaging showed lung fibrosis, bronchiectasis, and a fungal ball. He received weekly 600mg (10mg/kg) of liposomal amphotericin B for six weeks, leading to marked clinical improvement. Weekly liposomal amphotericin B may be a viable treatment option for CPA in resource-limited settings.http://www.sciencedirect.com/science/article/pii/S221175392400040XAspergillomaLiposomal amphotericin BTreatment outcomeResource limited settings |
| spellingShingle | Winnie Kibone Felix Bongomin David W. Denning David B. Meya Primary treatment of chronic pulmonary aspergillosis with weekly liposomal amphotericin B: A case report from Uganda Medical Mycology Case Reports Aspergilloma Liposomal amphotericin B Treatment outcome Resource limited settings |
| title | Primary treatment of chronic pulmonary aspergillosis with weekly liposomal amphotericin B: A case report from Uganda |
| title_full | Primary treatment of chronic pulmonary aspergillosis with weekly liposomal amphotericin B: A case report from Uganda |
| title_fullStr | Primary treatment of chronic pulmonary aspergillosis with weekly liposomal amphotericin B: A case report from Uganda |
| title_full_unstemmed | Primary treatment of chronic pulmonary aspergillosis with weekly liposomal amphotericin B: A case report from Uganda |
| title_short | Primary treatment of chronic pulmonary aspergillosis with weekly liposomal amphotericin B: A case report from Uganda |
| title_sort | primary treatment of chronic pulmonary aspergillosis with weekly liposomal amphotericin b a case report from uganda |
| topic | Aspergilloma Liposomal amphotericin B Treatment outcome Resource limited settings |
| url | http://www.sciencedirect.com/science/article/pii/S221175392400040X |
| work_keys_str_mv | AT winniekibone primarytreatmentofchronicpulmonaryaspergillosiswithweeklyliposomalamphotericinbacasereportfromuganda AT felixbongomin primarytreatmentofchronicpulmonaryaspergillosiswithweeklyliposomalamphotericinbacasereportfromuganda AT davidwdenning primarytreatmentofchronicpulmonaryaspergillosiswithweeklyliposomalamphotericinbacasereportfromuganda AT davidbmeya primarytreatmentofchronicpulmonaryaspergillosiswithweeklyliposomalamphotericinbacasereportfromuganda |