Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications
Fibrosis accompanies most common pathophysiological features of diabetes complications in different organs. It is characterized by an excessive accumulation of extracellular matrix (ECM) components, the response to which contributes to inevitable organ injury. The extracellular protein thrombospondi...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/8043135 |
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| _version_ | 1850229363131285504 |
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| author | Linhao Xu Yong Zhang Jian Chen Yizhou Xu |
| author_facet | Linhao Xu Yong Zhang Jian Chen Yizhou Xu |
| author_sort | Linhao Xu |
| collection | DOAJ |
| description | Fibrosis accompanies most common pathophysiological features of diabetes complications in different organs. It is characterized by an excessive accumulation of extracellular matrix (ECM) components, the response to which contributes to inevitable organ injury. The extracellular protein thrombospondin-1 (TSP-1), a kind of extracellular glycoprotein, is upregulated by the increased activity of some transcription factors and results in fibrosis by activating multiple pathways in diabetes. The results of studies from our team and other colleagues indicate that TSP-1 is associated with the pathological process leading to diabetic complications and is considered to be the most important factor in fibrosis. This review summarizes the molecular mechanism of increased TSP-1 induced by hyperglycemia and the role of TSP-1 in fibrosis during the development of diabetes complications. |
| format | Article |
| id | doaj-art-23dbee19c1d948a5899da31bcd5486a4 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-23dbee19c1d948a5899da31bcd5486a42025-08-20T02:04:15ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/80431358043135Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic ComplicationsLinhao Xu0Yong Zhang1Jian Chen2Yizhou Xu3Department of Cardiology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, 310006 Zhejiang, ChinaDepartment of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009 Zhejiang, ChinaSchool of Basic Medical Sciences & Forensic Medicine, Hangzhou Medical College, Hangzhou, 310053 Zhejiang, ChinaDepartment of Cardiology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, 310006 Zhejiang, ChinaFibrosis accompanies most common pathophysiological features of diabetes complications in different organs. It is characterized by an excessive accumulation of extracellular matrix (ECM) components, the response to which contributes to inevitable organ injury. The extracellular protein thrombospondin-1 (TSP-1), a kind of extracellular glycoprotein, is upregulated by the increased activity of some transcription factors and results in fibrosis by activating multiple pathways in diabetes. The results of studies from our team and other colleagues indicate that TSP-1 is associated with the pathological process leading to diabetic complications and is considered to be the most important factor in fibrosis. This review summarizes the molecular mechanism of increased TSP-1 induced by hyperglycemia and the role of TSP-1 in fibrosis during the development of diabetes complications.http://dx.doi.org/10.1155/2020/8043135 |
| spellingShingle | Linhao Xu Yong Zhang Jian Chen Yizhou Xu Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications Journal of Diabetes Research |
| title | Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications |
| title_full | Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications |
| title_fullStr | Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications |
| title_full_unstemmed | Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications |
| title_short | Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications |
| title_sort | thrombospondin 1 a key protein that induces fibrosis in diabetic complications |
| url | http://dx.doi.org/10.1155/2020/8043135 |
| work_keys_str_mv | AT linhaoxu thrombospondin1akeyproteinthatinducesfibrosisindiabeticcomplications AT yongzhang thrombospondin1akeyproteinthatinducesfibrosisindiabeticcomplications AT jianchen thrombospondin1akeyproteinthatinducesfibrosisindiabeticcomplications AT yizhouxu thrombospondin1akeyproteinthatinducesfibrosisindiabeticcomplications |