Meningococcal Sepsis in Patient with Paroxysmal Nocturnal Hemoglobinuria during Pegcetacoplan Therapy
Complement C5 inhibitors bring an increased risk for Neisseria infections. A novel complement C3 inhibitor, pegcetacoplan, was recently approved to treat paroxysmal nocturnal hemoglobinuria, a condition commonly treated with complement C5 inhibitors. We present a case of meningococcal sepsis in a p...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2025-03-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/31/3/24-1182_article |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850027713255964672 |
|---|---|
| author | Leo Starck Vuokko Nummi Eira Poikonen Anna-Elina Lehtinen Pia Kivelä Nathalie Friberg Jukka Torvikoski Maija Toropainen Seppo Meri |
| author_facet | Leo Starck Vuokko Nummi Eira Poikonen Anna-Elina Lehtinen Pia Kivelä Nathalie Friberg Jukka Torvikoski Maija Toropainen Seppo Meri |
| author_sort | Leo Starck |
| collection | DOAJ |
| description |
Complement C5 inhibitors bring an increased risk for Neisseria infections. A novel complement C3 inhibitor, pegcetacoplan, was recently approved to treat paroxysmal nocturnal hemoglobinuria, a condition commonly treated with complement C5 inhibitors. We present a case of meningococcal sepsis in a pegcetacoplan-treated patient with aplastic anemia and paroxysmal nocturnal hemoglobinuria.
|
| format | Article |
| id | doaj-art-23d863dfebc74c4e996f1449d47fdf5c |
| institution | DOAJ |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-23d863dfebc74c4e996f1449d47fdf5c2025-08-20T03:00:03ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-03-0131358358610.3201/eid3103.241182Meningococcal Sepsis in Patient with Paroxysmal Nocturnal Hemoglobinuria during Pegcetacoplan TherapyLeo StarckVuokko NummiEira PoikonenAnna-Elina LehtinenPia KiveläNathalie FribergJukka TorvikoskiMaija ToropainenSeppo Meri Complement C5 inhibitors bring an increased risk for Neisseria infections. A novel complement C3 inhibitor, pegcetacoplan, was recently approved to treat paroxysmal nocturnal hemoglobinuria, a condition commonly treated with complement C5 inhibitors. We present a case of meningococcal sepsis in a pegcetacoplan-treated patient with aplastic anemia and paroxysmal nocturnal hemoglobinuria. https://wwwnc.cdc.gov/eid/article/31/3/24-1182_articleMeningococcalsepsisparoxysmal nocturnal hemoglobinuriapegcetacoplanNeisseria meningitidiscomplement |
| spellingShingle | Leo Starck Vuokko Nummi Eira Poikonen Anna-Elina Lehtinen Pia Kivelä Nathalie Friberg Jukka Torvikoski Maija Toropainen Seppo Meri Meningococcal Sepsis in Patient with Paroxysmal Nocturnal Hemoglobinuria during Pegcetacoplan Therapy Emerging Infectious Diseases Meningococcal sepsis paroxysmal nocturnal hemoglobinuria pegcetacoplan Neisseria meningitidis complement |
| title | Meningococcal Sepsis in Patient with Paroxysmal Nocturnal Hemoglobinuria during Pegcetacoplan Therapy |
| title_full | Meningococcal Sepsis in Patient with Paroxysmal Nocturnal Hemoglobinuria during Pegcetacoplan Therapy |
| title_fullStr | Meningococcal Sepsis in Patient with Paroxysmal Nocturnal Hemoglobinuria during Pegcetacoplan Therapy |
| title_full_unstemmed | Meningococcal Sepsis in Patient with Paroxysmal Nocturnal Hemoglobinuria during Pegcetacoplan Therapy |
| title_short | Meningococcal Sepsis in Patient with Paroxysmal Nocturnal Hemoglobinuria during Pegcetacoplan Therapy |
| title_sort | meningococcal sepsis in patient with paroxysmal nocturnal hemoglobinuria during pegcetacoplan therapy |
| topic | Meningococcal sepsis paroxysmal nocturnal hemoglobinuria pegcetacoplan Neisseria meningitidis complement |
| url | https://wwwnc.cdc.gov/eid/article/31/3/24-1182_article |
| work_keys_str_mv | AT leostarck meningococcalsepsisinpatientwithparoxysmalnocturnalhemoglobinuriaduringpegcetacoplantherapy AT vuokkonummi meningococcalsepsisinpatientwithparoxysmalnocturnalhemoglobinuriaduringpegcetacoplantherapy AT eirapoikonen meningococcalsepsisinpatientwithparoxysmalnocturnalhemoglobinuriaduringpegcetacoplantherapy AT annaelinalehtinen meningococcalsepsisinpatientwithparoxysmalnocturnalhemoglobinuriaduringpegcetacoplantherapy AT piakivela meningococcalsepsisinpatientwithparoxysmalnocturnalhemoglobinuriaduringpegcetacoplantherapy AT nathaliefriberg meningococcalsepsisinpatientwithparoxysmalnocturnalhemoglobinuriaduringpegcetacoplantherapy AT jukkatorvikoski meningococcalsepsisinpatientwithparoxysmalnocturnalhemoglobinuriaduringpegcetacoplantherapy AT maijatoropainen meningococcalsepsisinpatientwithparoxysmalnocturnalhemoglobinuriaduringpegcetacoplantherapy AT seppomeri meningococcalsepsisinpatientwithparoxysmalnocturnalhemoglobinuriaduringpegcetacoplantherapy |