The interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity

The interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity

Abstract The thrombolytic protease tissue plasminogen activator (tPA) is expressed in the CNS, where it regulates diverse functions including neuronal plasticity, neuroinflammation, and blood-brain-barrier integrity. However, its role in different brain regions such as the substantia nigra (SN) is l...

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Bibliographic Details
Main Authors: Daniel Torrente, Enming J. Su, Alí Francisco Citalán-Madrid, Gerald P. Schielke, Daniel Magaoay, Mark Warnock, Tamara Stevenson, Kris Mann, Flavie Lesept, Nathalie Delétage, Manuel Blanc, Erin H. Norris, Denis Vivien, Daniel A. Lawrence
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Neuroinflammation
Subjects:
tPA
α-synuclein
Substantia nigra
Parkinson’s disease
Neuroinflammation
Dopaminergic neurons
Online Access:https://doi.org/10.1186/s12974-025-03336-3
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