Synthesis and properties of carbon quantum dots as an antimicrobial agent and detection of ciprofloxacin
Abstract This work reports a novel one-pot hydrothermal synthesis of N-CQDs using Solanum nigrum L. as sustainable carbon source and triethylamine as nitrogen provider. The resulting N-CQDs were systematically characterized with TEM, SEM, FT-IR, XPS, XRD, and UV–Visible. Significantly, the N-CQDs ex...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-14383-4 |
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| author | Fangzhou Shen Zhaoyang Lu Kangli Yan Kang Luo Shuchen Pei Pu Xiang |
| author_facet | Fangzhou Shen Zhaoyang Lu Kangli Yan Kang Luo Shuchen Pei Pu Xiang |
| author_sort | Fangzhou Shen |
| collection | DOAJ |
| description | Abstract This work reports a novel one-pot hydrothermal synthesis of N-CQDs using Solanum nigrum L. as sustainable carbon source and triethylamine as nitrogen provider. The resulting N-CQDs were systematically characterized with TEM, SEM, FT-IR, XPS, XRD, and UV–Visible. Significantly, the N-CQDs exhibited substantial antimicrobial efficacy against both S. aureus and E. coli bacterial strains, with minimum inhibitory concentration values of 1.2 mg/mL and 1.1 mg/mL, respectively. Moreover, the N-CQDs demonstrated pronounced fluorescence enhancement upon interaction with ciprofloxacin, displaying exceptional selectivity and sensitivity, with a calculated LOD of 316 nM. The feasibility of employing N-CQDs as fluorescent probes for ciprofloxacin detection was systematically validated through practical application in honey analysis. This study introduces a novel approach for the fabrication of N-CQDs derived from natural botanical sources, underscoring their potential dual functionality as fluorescent sensors and antimicrobial materials. |
| format | Article |
| id | doaj-art-23d5a879dea34d219b555cf50ce36efc |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-23d5a879dea34d219b555cf50ce36efc2025-08-20T03:05:21ZengNature PortfolioScientific Reports2045-23222025-08-0115111010.1038/s41598-025-14383-4Synthesis and properties of carbon quantum dots as an antimicrobial agent and detection of ciprofloxacinFangzhou Shen0Zhaoyang Lu1Kangli Yan2Kang Luo3Shuchen Pei4Pu Xiang5Dermatology, University-Town Hospital of Chongqing Medical UniversitySchool of Chemistry and Chemical Engineering, Chongqing University of Science and TechnologySchool of Chemistry and Chemical Engineering, Chongqing University of Science and TechnologyDepartment of Pharmacy, People’s Hospital Affiliated to Chongqing Three Gorges Medical CollegeSchool of Chemistry and Chemical Engineering, Chongqing University of Science and TechnologyDepartment of Pharmacy, The People’s Hospital of Dianjiang CountyAbstract This work reports a novel one-pot hydrothermal synthesis of N-CQDs using Solanum nigrum L. as sustainable carbon source and triethylamine as nitrogen provider. The resulting N-CQDs were systematically characterized with TEM, SEM, FT-IR, XPS, XRD, and UV–Visible. Significantly, the N-CQDs exhibited substantial antimicrobial efficacy against both S. aureus and E. coli bacterial strains, with minimum inhibitory concentration values of 1.2 mg/mL and 1.1 mg/mL, respectively. Moreover, the N-CQDs demonstrated pronounced fluorescence enhancement upon interaction with ciprofloxacin, displaying exceptional selectivity and sensitivity, with a calculated LOD of 316 nM. The feasibility of employing N-CQDs as fluorescent probes for ciprofloxacin detection was systematically validated through practical application in honey analysis. This study introduces a novel approach for the fabrication of N-CQDs derived from natural botanical sources, underscoring their potential dual functionality as fluorescent sensors and antimicrobial materials.https://doi.org/10.1038/s41598-025-14383-4Nitrogen dopingAntibacterialCiprofloxacinCarbon quantum dots |
| spellingShingle | Fangzhou Shen Zhaoyang Lu Kangli Yan Kang Luo Shuchen Pei Pu Xiang Synthesis and properties of carbon quantum dots as an antimicrobial agent and detection of ciprofloxacin Scientific Reports Nitrogen doping Antibacterial Ciprofloxacin Carbon quantum dots |
| title | Synthesis and properties of carbon quantum dots as an antimicrobial agent and detection of ciprofloxacin |
| title_full | Synthesis and properties of carbon quantum dots as an antimicrobial agent and detection of ciprofloxacin |
| title_fullStr | Synthesis and properties of carbon quantum dots as an antimicrobial agent and detection of ciprofloxacin |
| title_full_unstemmed | Synthesis and properties of carbon quantum dots as an antimicrobial agent and detection of ciprofloxacin |
| title_short | Synthesis and properties of carbon quantum dots as an antimicrobial agent and detection of ciprofloxacin |
| title_sort | synthesis and properties of carbon quantum dots as an antimicrobial agent and detection of ciprofloxacin |
| topic | Nitrogen doping Antibacterial Ciprofloxacin Carbon quantum dots |
| url | https://doi.org/10.1038/s41598-025-14383-4 |
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