The Sex-Dependent Ameliorative Effect of Intermittent Fasting on Urinary System Functions in Genetic Absence Epileptic Rats
Epilepsy, a brain condition causing recurrent seizures, can disrupt various body functions, including urination. This study explored how alternate-day fasting (ADF), a type of intermittent fasting, a diet involving one day of eating and fasting, subsequently affects urinary system health in epilepti...
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MDPI AG
2025-02-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/14/2/158 |
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| author | Damla Gökçeoğlu-Kayalı Mehmet Ali Berkyürek Zarife Nigar Özdemir-Kumral Özlem Tuğçe Çilingir-Kaya |
| author_facet | Damla Gökçeoğlu-Kayalı Mehmet Ali Berkyürek Zarife Nigar Özdemir-Kumral Özlem Tuğçe Çilingir-Kaya |
| author_sort | Damla Gökçeoğlu-Kayalı |
| collection | DOAJ |
| description | Epilepsy, a brain condition causing recurrent seizures, can disrupt various body functions, including urination. This study explored how alternate-day fasting (ADF), a type of intermittent fasting, a diet involving one day of eating and fasting, subsequently affects urinary system health in epileptic rats. Using a genetic rat model of epilepsy, we examined bladder and kidney function through tissue analysis, biochemical tests, and physiological assessments, focusing on differences between males and females. The results showed that epilepsy causes significant urinary system damage linked to inflammation and oxidative stress. However, ADF reduces this damage by lowering inflammation and restoring antioxidant balance. Male rats exhibited more oxidative damage, while female rats responded better to ADF, likely due to hormonal differences. These findings suggest ADF as a potential, cost-effective dietary approach to protect against urinary complications in epilepsy and similar conditions. Understanding these effects may lead to improved treatments for both genders and a better quality of life for people with chronic diseases. |
| format | Article |
| id | doaj-art-23d15edccdcb401883eaa4be2ddd496d |
| institution | DOAJ |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-23d15edccdcb401883eaa4be2ddd496d2025-08-20T03:12:20ZengMDPI AGBiology2079-77372025-02-0114215810.3390/biology14020158The Sex-Dependent Ameliorative Effect of Intermittent Fasting on Urinary System Functions in Genetic Absence Epileptic RatsDamla Gökçeoğlu-Kayalı0Mehmet Ali Berkyürek1Zarife Nigar Özdemir-Kumral2Özlem Tuğçe Çilingir-Kaya3Histology and Embryology Department, Marmara University School of Medicine, Istanbul 34854, TürkiyeHistology and Embryology Department, Marmara University School of Medicine, Istanbul 34854, TürkiyePhysiology Department, Marmara University School of Medicine, Istanbul 34854, TürkiyeHistology and Embryology Department, Marmara University School of Medicine, Istanbul 34854, TürkiyeEpilepsy, a brain condition causing recurrent seizures, can disrupt various body functions, including urination. This study explored how alternate-day fasting (ADF), a type of intermittent fasting, a diet involving one day of eating and fasting, subsequently affects urinary system health in epileptic rats. Using a genetic rat model of epilepsy, we examined bladder and kidney function through tissue analysis, biochemical tests, and physiological assessments, focusing on differences between males and females. The results showed that epilepsy causes significant urinary system damage linked to inflammation and oxidative stress. However, ADF reduces this damage by lowering inflammation and restoring antioxidant balance. Male rats exhibited more oxidative damage, while female rats responded better to ADF, likely due to hormonal differences. These findings suggest ADF as a potential, cost-effective dietary approach to protect against urinary complications in epilepsy and similar conditions. Understanding these effects may lead to improved treatments for both genders and a better quality of life for people with chronic diseases.https://www.mdpi.com/2079-7737/14/2/158fastingurination disordersbladdersex differenceabsence epilepsy |
| spellingShingle | Damla Gökçeoğlu-Kayalı Mehmet Ali Berkyürek Zarife Nigar Özdemir-Kumral Özlem Tuğçe Çilingir-Kaya The Sex-Dependent Ameliorative Effect of Intermittent Fasting on Urinary System Functions in Genetic Absence Epileptic Rats Biology fasting urination disorders bladder sex difference absence epilepsy |
| title | The Sex-Dependent Ameliorative Effect of Intermittent Fasting on Urinary System Functions in Genetic Absence Epileptic Rats |
| title_full | The Sex-Dependent Ameliorative Effect of Intermittent Fasting on Urinary System Functions in Genetic Absence Epileptic Rats |
| title_fullStr | The Sex-Dependent Ameliorative Effect of Intermittent Fasting on Urinary System Functions in Genetic Absence Epileptic Rats |
| title_full_unstemmed | The Sex-Dependent Ameliorative Effect of Intermittent Fasting on Urinary System Functions in Genetic Absence Epileptic Rats |
| title_short | The Sex-Dependent Ameliorative Effect of Intermittent Fasting on Urinary System Functions in Genetic Absence Epileptic Rats |
| title_sort | sex dependent ameliorative effect of intermittent fasting on urinary system functions in genetic absence epileptic rats |
| topic | fasting urination disorders bladder sex difference absence epilepsy |
| url | https://www.mdpi.com/2079-7737/14/2/158 |
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