Complicated crosstalk between HMGA and non-coding RNAs modulates hallmarks of cancer
Abstract High mobility group A1 (HMGA1) is a class of non-histone chromosomal protein and is highly expressed in the embryonic period and many tumors. It is involved in multiple hallmarks of tumors and affects the occurrence and progression of tumors. Nowadays, many non-coding RNAs (ncRNAs), such as...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | Cancer Cell International |
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| Online Access: | https://doi.org/10.1186/s12935-025-03713-1 |
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| author | Lijie Zhang Xiaomin Zhao Xianghong Gao Hao Qin Feng Chen Zhijuan Lin |
| author_facet | Lijie Zhang Xiaomin Zhao Xianghong Gao Hao Qin Feng Chen Zhijuan Lin |
| author_sort | Lijie Zhang |
| collection | DOAJ |
| description | Abstract High mobility group A1 (HMGA1) is a class of non-histone chromosomal protein and is highly expressed in the embryonic period and many tumors. It is involved in multiple hallmarks of tumors and affects the occurrence and progression of tumors. Nowadays, many non-coding RNAs (ncRNAs), such as miRNA, lncRNA, and circRNA, have been found to play a crucial role in HMGA1 regulation. Moreover, some ncRNAs are reported to be the downstream effectors of HMGA1. They interact with each other to affect multiple hallmarks of cancer and targeting ncRNAs or HMGA1 may provide potential strategies for cancer therapy. In this review, we give an overview of recent studies describing the crosstalk between oncogenic HMGA1 and ncRNAs. We also point out the impact of this interaction on the biological behavior of tumors and their potential in tumor therapy in order to offer potential implications and directions for both basic science and clinical applications. |
| format | Article |
| id | doaj-art-23d0fbf782c44cd89fd086dc2deff763 |
| institution | DOAJ |
| issn | 1475-2867 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj-art-23d0fbf782c44cd89fd086dc2deff7632025-08-20T02:47:07ZengBMCCancer Cell International1475-28672025-03-0125111310.1186/s12935-025-03713-1Complicated crosstalk between HMGA and non-coding RNAs modulates hallmarks of cancerLijie Zhang0Xiaomin Zhao1Xianghong Gao2Hao Qin3Feng Chen4Zhijuan Lin5Key Laboratory for Immunology in Universities of Shandong Province, School of Basic Medicine Sciences, Shandong Second Medical UniversityKey Laboratory for Immunology in Universities of Shandong Province, School of Basic Medicine Sciences, Shandong Second Medical UniversityKey Laboratory for Immunology in Universities of Shandong Province, School of Basic Medicine Sciences, Shandong Second Medical UniversityKey Laboratory for Immunology in Universities of Shandong Province, School of Basic Medicine Sciences, Shandong Second Medical UniversityWeifang Hospital of Traditional Chinese Medicine, Shandong Second Medical UniversityKey Laboratory for Immunology in Universities of Shandong Province, School of Basic Medicine Sciences, Shandong Second Medical UniversityAbstract High mobility group A1 (HMGA1) is a class of non-histone chromosomal protein and is highly expressed in the embryonic period and many tumors. It is involved in multiple hallmarks of tumors and affects the occurrence and progression of tumors. Nowadays, many non-coding RNAs (ncRNAs), such as miRNA, lncRNA, and circRNA, have been found to play a crucial role in HMGA1 regulation. Moreover, some ncRNAs are reported to be the downstream effectors of HMGA1. They interact with each other to affect multiple hallmarks of cancer and targeting ncRNAs or HMGA1 may provide potential strategies for cancer therapy. In this review, we give an overview of recent studies describing the crosstalk between oncogenic HMGA1 and ncRNAs. We also point out the impact of this interaction on the biological behavior of tumors and their potential in tumor therapy in order to offer potential implications and directions for both basic science and clinical applications.https://doi.org/10.1186/s12935-025-03713-1LncRNACircRNAHMGA1TumorigenesisTargeted therapy |
| spellingShingle | Lijie Zhang Xiaomin Zhao Xianghong Gao Hao Qin Feng Chen Zhijuan Lin Complicated crosstalk between HMGA and non-coding RNAs modulates hallmarks of cancer Cancer Cell International LncRNA CircRNA HMGA1 Tumorigenesis Targeted therapy |
| title | Complicated crosstalk between HMGA and non-coding RNAs modulates hallmarks of cancer |
| title_full | Complicated crosstalk between HMGA and non-coding RNAs modulates hallmarks of cancer |
| title_fullStr | Complicated crosstalk between HMGA and non-coding RNAs modulates hallmarks of cancer |
| title_full_unstemmed | Complicated crosstalk between HMGA and non-coding RNAs modulates hallmarks of cancer |
| title_short | Complicated crosstalk between HMGA and non-coding RNAs modulates hallmarks of cancer |
| title_sort | complicated crosstalk between hmga and non coding rnas modulates hallmarks of cancer |
| topic | LncRNA CircRNA HMGA1 Tumorigenesis Targeted therapy |
| url | https://doi.org/10.1186/s12935-025-03713-1 |
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