Determining factors for dexmedetomidine sedation in endoscopic submucosal dissection for early‐stage gastric cancer
Abstract Background and Aim Although no specific sedation recommendations exist in early‐stage gastric cancer (ESGC) for endoscopic submucosal dissection (ESD), dexmedetomidine (DEX) is useful along with benzodiazepines and analgesics. Furthermore, DEX is used for endoscopic treatment requiring leng...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-05-01
|
| Series: | JGH Open |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jgh3.13065 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849429531343978496 |
|---|---|
| author | Erika Yoshida Yorimasa Yamamoto Misako Tohata Kuniyo Gomi Tadashi Okayasu Masatsugu Nagahama |
| author_facet | Erika Yoshida Yorimasa Yamamoto Misako Tohata Kuniyo Gomi Tadashi Okayasu Masatsugu Nagahama |
| author_sort | Erika Yoshida |
| collection | DOAJ |
| description | Abstract Background and Aim Although no specific sedation recommendations exist in early‐stage gastric cancer (ESGC) for endoscopic submucosal dissection (ESD), dexmedetomidine (DEX) is useful along with benzodiazepines and analgesics. Furthermore, DEX is used for endoscopic treatment requiring lengthy sedation. However, it is unclear which patients should be administered DEX. We examined the factors that determine when DEX should be added for sedation during ESD for ESGC. Methods Of 316 patients undergoing ESD for ESGC at our hospital between January 2017 and December 2020, we examined 310 receiving intravenous anesthesia. Preoperative patient factors and treatment outcomes were retrospectively examined according to the sedation method. Results Among patients with ESGC undergoing ESD at our hospital, DEX was more frequently used alongside sedation in men, those undergoing gastrectomy, those with a lesion diameter ≥20 mm, and those with preoperative ulcers. In the standard group, patients whose treatment duration exceeded 120 min typically had a lesion diameter ≥20 mm, preoperative ulcers, lesions located outside the L region, and were treated by junior physicians. Conclusion It is important to evaluate specific preoperative factors (lesion diameter ≥20 mm, preoperative ulcers, lesion located outside the L region, and having a junior physician as the treating physician) in patients undergoing ESD for ESGC to determine whether the combined use of DEX in sedation is necessary. |
| format | Article |
| id | doaj-art-23cc3dce388946df9626de5b4dbb6bb8 |
| institution | Kabale University |
| issn | 2397-9070 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj-art-23cc3dce388946df9626de5b4dbb6bb82025-08-20T03:28:19ZengWileyJGH Open2397-90702024-05-0185n/an/a10.1002/jgh3.13065Determining factors for dexmedetomidine sedation in endoscopic submucosal dissection for early‐stage gastric cancerErika Yoshida0Yorimasa Yamamoto1Misako Tohata2Kuniyo Gomi3Tadashi Okayasu4Masatsugu Nagahama5Division of Gastroenterology Showa University Fujigaoka Hospital Yokohama JapanInternal Medicine Hitachi Zosen Health Insurance Union, Innoshima General Hospital Hiroshima JapanDivision of Gastroenterology Showa University Fujigaoka Hospital Yokohama JapanDivision of Gastroenterology Showa University Fujigaoka Hospital Yokohama JapanAnesthesiology Showa University Fujigaoka Hospital Yokohama JapanDivision of Gastroenterology Showa University Fujigaoka Hospital Yokohama JapanAbstract Background and Aim Although no specific sedation recommendations exist in early‐stage gastric cancer (ESGC) for endoscopic submucosal dissection (ESD), dexmedetomidine (DEX) is useful along with benzodiazepines and analgesics. Furthermore, DEX is used for endoscopic treatment requiring lengthy sedation. However, it is unclear which patients should be administered DEX. We examined the factors that determine when DEX should be added for sedation during ESD for ESGC. Methods Of 316 patients undergoing ESD for ESGC at our hospital between January 2017 and December 2020, we examined 310 receiving intravenous anesthesia. Preoperative patient factors and treatment outcomes were retrospectively examined according to the sedation method. Results Among patients with ESGC undergoing ESD at our hospital, DEX was more frequently used alongside sedation in men, those undergoing gastrectomy, those with a lesion diameter ≥20 mm, and those with preoperative ulcers. In the standard group, patients whose treatment duration exceeded 120 min typically had a lesion diameter ≥20 mm, preoperative ulcers, lesions located outside the L region, and were treated by junior physicians. Conclusion It is important to evaluate specific preoperative factors (lesion diameter ≥20 mm, preoperative ulcers, lesion located outside the L region, and having a junior physician as the treating physician) in patients undergoing ESD for ESGC to determine whether the combined use of DEX in sedation is necessary.https://doi.org/10.1002/jgh3.13065dexmedetomidineearly‐stage gastric cancerendoscopic submucosal dissection |
| spellingShingle | Erika Yoshida Yorimasa Yamamoto Misako Tohata Kuniyo Gomi Tadashi Okayasu Masatsugu Nagahama Determining factors for dexmedetomidine sedation in endoscopic submucosal dissection for early‐stage gastric cancer JGH Open dexmedetomidine early‐stage gastric cancer endoscopic submucosal dissection |
| title | Determining factors for dexmedetomidine sedation in endoscopic submucosal dissection for early‐stage gastric cancer |
| title_full | Determining factors for dexmedetomidine sedation in endoscopic submucosal dissection for early‐stage gastric cancer |
| title_fullStr | Determining factors for dexmedetomidine sedation in endoscopic submucosal dissection for early‐stage gastric cancer |
| title_full_unstemmed | Determining factors for dexmedetomidine sedation in endoscopic submucosal dissection for early‐stage gastric cancer |
| title_short | Determining factors for dexmedetomidine sedation in endoscopic submucosal dissection for early‐stage gastric cancer |
| title_sort | determining factors for dexmedetomidine sedation in endoscopic submucosal dissection for early stage gastric cancer |
| topic | dexmedetomidine early‐stage gastric cancer endoscopic submucosal dissection |
| url | https://doi.org/10.1002/jgh3.13065 |
| work_keys_str_mv | AT erikayoshida determiningfactorsfordexmedetomidinesedationinendoscopicsubmucosaldissectionforearlystagegastriccancer AT yorimasayamamoto determiningfactorsfordexmedetomidinesedationinendoscopicsubmucosaldissectionforearlystagegastriccancer AT misakotohata determiningfactorsfordexmedetomidinesedationinendoscopicsubmucosaldissectionforearlystagegastriccancer AT kuniyogomi determiningfactorsfordexmedetomidinesedationinendoscopicsubmucosaldissectionforearlystagegastriccancer AT tadashiokayasu determiningfactorsfordexmedetomidinesedationinendoscopicsubmucosaldissectionforearlystagegastriccancer AT masatsugunagahama determiningfactorsfordexmedetomidinesedationinendoscopicsubmucosaldissectionforearlystagegastriccancer |