Efficacy and safety of avatrombopag in combination with immunosuppressive therapy in treatment-naïve and relapsed/refractory severe aplastic anaemia: protocol for the DIAAMOND-Ava-FIRST and DIAAMOND-Ava-NEXT Bayesian Optimal Phase II trials

Efficacy and safety of avatrombopag in combination with immunosuppressive therapy in treatment-naïve and relapsed/refractory severe aplastic anaemia: protocol for the DIAAMOND-Ava-FIRST and DIAAMOND-Ava-NEXT Bayesian Optimal Phase II trials

Introduction Immunosuppressive therapy (IST) with antithymocyte globulin (ATG) and ciclosporin is standard of care for patients with severe aplastic anaemia (sAA) not eligible or suitable for allogeneic stem cell transplant. While patients respond to IST, few achieve complete responses and a signifi...

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Main Authors: Stephane Heritier, Alisa Higgins, Piers Blombery, Robin Filshie, Paul Lacaze, Kate Wilson, William Stevenson, Lauren Young, Zoe McQuilten, Jennifer Curnow, Lucy Fox, Vanessa Fox, Ilona Cunningham, Devendra K Hiwase, Frank Firkin, Kylie Mason, Anthony K Mills, Dominic Pepperell, Sushrut Patil, Jeff Szer, Neil Waters, Stephen Ting, Erica Wood
Format: Article
Language:English
Published: BMJ Publishing Group 2024-01-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/14/1/e076246.full
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