Predicting immune-related adverse events in patients with melanoma: the role of interleukin-7 rs16906115 polymorphism and lymphocyte dynamics

Predicting immune-related adverse events in patients with melanoma: the role of interleukin-7 rs16906115 polymorphism and lymphocyte dynamics

IntroductionImmune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape of malignant melanoma; however, they are frequently associated with immune-related adverse events (irAEs). Emerging evidence suggests that genetic predispositions, including interleukin-7 (IL-7) gene variants,...

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Main Authors: Fatma Pınar Açar, Caner Acar, Damla Gunenc, Çağlar Arisoy, Asli Ece Solmaz, Asli Gecgel, Haydar Çağatay Yüksel, Gökhan Şahin, Oguzcan Ozkan, Zeynep Sila Gokdere, Nilay Duman, Burçak Karaca
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
immune checkpoint inhibitors
rs16906115 polymorphism
lymphocyte stability index
melanoma
genetic predisposition
immune-related adverse events
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1616325/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1616325/full

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