An exosome-based nanoplatform for siRNA delivery combined with starvation therapy promotes tumor cell death through autophagy, overcoming refractory KRAS-mutated tumors and restoring cetuximab chemosensitivity

An exosome-based nanoplatform for siRNA delivery combined with starvation therapy promotes tumor cell death through autophagy, overcoming refractory KRAS-mutated tumors and restoring cetuximab chemosensitivity

Multi-drug combination therapy is one of the most effective strategies for the treatment of drug-resistant and advanced tumors. Modern nanodrug delivery systems are crucial for multi-drug combination therapy and gene therapy. However, research on direct injection of RNAi has not yielded significant...

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Bibliographic Details
Main Authors: Yurong Xiang, Qiang Liu, Kang Liu, Liuxian Chen, Fengjiao Chen, Tao Li, Siqi Li, Qiang Yu, Quan Lv, Zheng Xiang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Materials Today Bio
Subjects:
Colorectal cancer
KRAS mutation
Starvation therapy
Exosome
Cetuximab chemosensitivity
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425002911
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